Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2 von Ferreira, Juliana C., Rabeh, Wael M.

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Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2 von Ferreira, Juliana C., Fadl, Samar, Rabeh, Wael M.

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Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease von Ferreira, Juliana C., Fadl, Samar, Villanueva, Adrian J., Rabeh, Wael M.

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Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane von Okiyoneda, Tsukasa, Barrière, Hervé, Bagdány, Miklós, Rabeh, Wael M, Du, Kai, Höhfeld, Jörg, Young, Jason C, Lukacs, Gergely L

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Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function von Rabeh, Wael M., Bossard, Florian, Xu, Haijin, Okiyoneda, Tsukasa, Bagdany, Miklos, Mulvihill, Cory M., Du, Kai, di Bernardo, Salvatore, Liu, Yuhong, Konermann, Lars, Roldan, Ariel, Lukacs, Gergely L.

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The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation von Nawaz, Mir Hussain, Ferreira, Juliana C, Nedyalkova, Lyudmila, Zhu, Haizhong, Carrasco-López, César, Kirmizialtin, Serdal, Rabeh, Wael M

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The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation von Mahgoub, Radwa E, Mohamed, Feda E, Alzyoud, Lara, Ali, Bassam R, Ferreira, Juliana, Rabeh, Wael M, AlNeyadi, Shaikha S, Atatreh, Noor, Ghattas, Mohammad A

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3-chymotrypsin-like protease in SARS-CoV-2 von Al Adem, Kenana, Ferreira, Juliana C, Villanueva, Adrian J, Fadl, Samar, El-Sadaany, Farah, Masmoudi, Imen, Gidiya, Yugmee, Gurudza, Tariro, Cardoso, Thyago H S, Saksena, Nitin K, Rabeh, Wael M

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Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway von Ahner, Annette, Gong, Xiaoyan, Schmidt, Bela Z, Peters, Kathryn W, Rabeh, Wael M, Thibodeau, Patrick H, Lukacs, Gergely L, Frizzell, Raymond A

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Boosting immunity: synergistic antiviral effects of luteolin, vitamin C, magnesium and zinc against SARS-CoV-2 3CLpro von Ferreira, Juliana C, Fadl, Samar, Cardoso, Thyago H S, Andrade, Bruno Silva, Melo, Tarcisio S, Silva, Edson Mario de Andrade, Agarwal, Anupriya, Turville, Stuart J, Saksena, Nitin K, Rabeh, Wael M

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Nicotinamide riboside kinase structures reveal new pathways to NAD von Tempel, Wolfram, Rabeh, Wael M, Bogan, Katrina L, Belenky, Peter, Wojcik, Marzena, Seidle, Heather F, Nedyalkova, Lyudmila, Yang, Tianle, Sauve, Anthony A, Park, Hee-Won, Brenner, Charles

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The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action von Naumov, Panče, Yasuda, Nobuhiro, Rabeh, Wael M, Bernstein, Joel

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pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity von Al Adem, Kenana, Ferreira, Juliana C., Fadl, Samar, Rabeh, Wael M.

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Key Allosteric and Active Site Residues of SARS-CoV-2 3CLpro Are Promising Drug Targets von Al Adem, Kenana, Ferreira, Juliana C, Fadl, Samar, Mustafa, Morad, Rabeh, Wael M

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Hexokinase II–derived cell‐penetrating peptide targets mitochondria and triggers apoptosis in cancer cells von Woldetsadik, Abiy D., Vogel, Maria C., Rabeh, Wael M., Magzoub, Mazin

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Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS‐CoV‐2 protease 3CLpro von Ferreira, Juliana C., Fadl, Samar, Ilter, Metehan, Pekel, Hanife, Rezgui, Rachid, Sensoy, Ozge, Rabeh, Wael M.

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Structure and Mechanism of O-Acetylserine Sulfhydrylase von Rabeh, Wael M., Cook, Paul F.

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Identification of novel allosteric sites of SARS-CoV-2 papain-like protease (PLpro) for the development of COVID-19 antivirals von Ferreira, Juliana C., Villanueva, Adrian J., Al Adem, Kenana, Fadl, Samar, Alzyoud, Lara, Ghattas, Mohammad A., Rabeh, Wael M.

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Structure, Mechanism, and Conformational Dynamics of O-Acetylserine Sulfhydrylase from Salmonella typhimurium:  Comparison of A and B Isozymes von Chattopadhyay, Arundhati, Meier, Markus, Ivaninskii, Sergei, Burkhard, Peter, Speroni, Francesca, Campanini, Barbara, Bettati, Stefano, Mozzarelli, Andrea, Rabeh, Wael M, Li, Lei, Cook, Paul F

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Residues in the fructose-binding pocket are required for ketohexokinase-A activity von Ferreira, Juliana C., Villanueva, Adrian J., Fadl, Samar, Al Adem, Kenana, Cinviz, Zeynep Nur, Nedyalkova, Lyudmila, Cardoso, Thyago H.S., Andrade, Mario Edson, Saksena, Nitin K., Sensoy, Ozge, Rabeh, Wael M.

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