Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Au... von Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray

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Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds von Meyers, Marvin J., Long, Scott A., Pelc, Matthew J., Wang, Jane L., Bowen, Scott J., Walker, Mark C., Schweitzer, Barbara A., Madsen, Heather M., Tenbrink, Ruth E., McDonald, Joseph, Smith, Sarah E., Foltin, Susan, Beidler, David, Thorarensen, Atli

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Structure based design of novel irreversible FAAH inhibitors von Wang, Jane L., Bowen, Scott J., Schweitzer, Barbara A., Madsen, Heather M., McDonald, Joseph, Pelc, Matthew J., Tenbrink, Ruth E., Beidler, David, Thorarensen, Atli

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Antagonist, Partial Agonist, and Full Agonist Imidazo[1,5-a]quinoxaline Amides and Carbamates Acting through the GABAA/Benzodiazepine Receptor von TenBrink, Ruth E, Im, Wha B, Sethy, Vimala H, Tang, Andrew H, Carter, Don B

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High-Affinity Partial Agonist Imidazo[1,5-a]quinoxaline Amides, Carbamates, and Ureas at the γ-Aminobutyric Acid A/Benzodiazepine Receptor Complex von Jacobsen, E. Jon, TenBrink, Ruth E, Stelzer, Lindsay S, Belonga, Kenneth L, Carter, Donald B, Im, Haesook K, Im, Wha Bin, Sethy, Vimala H, Tang, Andy H, VonVoigtlander, Philip F, Petke, James D

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Potent and selective isophthalamide S 2 hydroxyethylamine inhibitors of BACE1 von Kortum, Steven W., Benson, Timothy E., Bienkowski, Michael J., Emmons, Thomas L., Prince, D. Bryan, Paddock, Donna J., Tomasselli, Alfredo G., Moon, Joseph B., LaBorde, Alice, TenBrink, Ruth E.

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A method for the preparation of stereochemically defined .psi.[CH2O] pseudodipeptides von TenBrink, Ruth E

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Piperazine Imidazo[1,5-a]quinoxaline Ureas as High-Affinity GABAA Ligands of Dual Functionality von Jacobsen, E. Jon, Stelzer, Lindsay S, TenBrink, Ruth E, Belonga, Kenneth L, Carter, Donald B, Im, Haesook K, Im, Wha Bin, Sethy, Vimala H, Tang, Andy H, VonVoigtlander, Philip F, Petke, James D, Zhong, Wei-Zhu, Mickelson, John W

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Thienopyrimidine-based P2Y sub(12) platelet aggregation inhibitors von Kortum, Steven W, Lachance, Rhonda M, Schweitzer, Barbara A, Yalamanchili, Gopichand, Rahman, Hayat, Ennis, Michael D, Huff, Rita M, TenBrink, Ruth E

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Differential pharmacology between the guinea‐pig and the gorilla 5‐HT 1D receptor as probed with isochromans (5‐HT 1D ‐selective ligands) von Pregenzer, Jeffrey F, Alberts, Glen L, Im, Wha Bin, Slightom, Jerry L, Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, TenBrink, Ruth E

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Potent and selective isophthalamide S sub(2) hydroxyethylamine inhibitors of BACE1 von Kortum, Steven W, Benson, Timothy E, Bienkowski, Michael J, Emmons, Thomas L, Prince, DBryan, Paddock, Donna J, Tomasselli, Alfredo G, Moon, Joseph B, LaBorde, Alice, TenBrink, Ruth E

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( S )-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D 4 Antagonist von TenBrink, Ruth E., Bergh, Carol L., Duncan, J. Neil, Harris, Douglas W., Huff, R. M., Lahti, Robert A., Lawson, Charles F., Lutzke, Barry S., Martin, Iain J., Rees, Susan A., Schlachter, Siusaidh K., Sih, John C., Smith, Martin W.

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Differential pharmacology between the guinea‐pig and the gorilla 5‐HT1D receptor as probed with isochromans (5‐HT1D‐selective ligands) von Pregenzer, Jeffrey F, Alberts, Glen L, Im, Wha Bin, Slightom, Jerry L, Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, TenBrink, Ruth E

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Tetrahydro-2-benzoxepins: a novel family of hypotensives von TenBrink, Ruth E, McCall, John M, Pals, Donald T, McCall, Robert B, Orley, John, Humphrey, Steve J, Wendling, Michael G

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PYRIDYLSULFON-DERIVATE ALS 5-HT6 REZEPTOR LIGANDEN von KORTUM, STEVEN, TENBRINK, RUTH

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Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of Janus-related Kinases (JAK) von TENBRINK Ruth E, UNWALLA Rayomand Jal, BROWN Matthew Frank, KAILA Neelu, FENWICK Ashley Edward, MITTON-FRY Mark J, PARIKH Mihir D, FLANAGAN Mark Edward, JOHNSON Timothy Allan, STROHBACH Joseph Walter, GONZALES Andrea, TRZUPEK John David, VAZQUEZ Michael L

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Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of Janus-related Kinases (JAK) von TENBRINK Ruth E, UNWALLA Rayomand Jal, BROWN Matthew Frank, KAILA Neelu, FENWICK Ashley Edward, MITTON-FRY Mark J, PARIKH Mihir D, FLANAGAN Mark Edward, JOHNSON Timothy Allan, STROHBACH Joseph Walter, GONZALES Andrea, TRZUPEK John David, VAZQUEZ Michael L

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Oxazinocarbazoles for the treatment of CNS diseases von TenBrink, Ruth

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COMBINATION OF PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES WITH ONE OR MORE ADDITIONAL AGENTS AS INHIBITORS OF JANUS- RELATED KINASES (JAK) von FLANAGAN, Mark Edward, TRZUPEK, John David, STROHBACH, Joseph Walter, TENBRINK, Ruth E, JOHNSON, Timothy Allan, KAILA, Neelu, GONZALES, Andrea, UNWALLA, Rayomand Jal, VAZQUEZ, Michael L, PARIKH, Mihir, D, MITTON-FRY, Mark J, BROWN, Matthew Frank, FENWICK, Ashley Edward

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COMBINATION OF PYRROLO [2, 3 -D]PYRIMIDINE DERIVATIVES WITH ONE OR MORE ADDITIONAL AGENTS AS INHIBITORS OF JANUS- RELATED KINASES (JAK) von FLANAGAN, Mark Edward, TRZUPEK, John David, STROHBACH, Joseph Walter, TENBRINK, Ruth E, JOHNSON, Timothy Allan, KAILA, Neelu, GONZALES, Andrea, UNWALLA, Rayomand Jal, VAZQUEZ, Michael L, PARIKH, Mihir, D, MITTON-FRY, Mark J, BROWN, Matthew Frank, FENWICK, Ashley Edward

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