A Shape-Based 3-D Scaffold Hopping Method and Its Application to a Bacterial Protein−Protein Interaction von Rush, Thomas S, Grant, J. Andrew, Mosyak, Lidia, Nicholls, Anthony

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Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycline von OLSON, Matthew W, RUZIN, Alexey, FEYFANT, Eric, RUSH, Thomas S, O'CONNELL, John, BRADFORD, Patricia A

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Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors von Moschos, Stergios J, Sullivan, Ryan J, Hwu, Wen-Jen, Ramanathan, Ramesh K, Adjei, Alex A, Fong, Peter C, Shapira-Frommer, Ronnie, Tawbi, Hussein A, Rubino, Joseph, Rush, 3rd, Thomas S, Zhang, Da, Miselis, Nathan R, Samatar, Ahmed A, Chun, Patrick, Rubin, Eric H, Schiller, James, Long, Brian J, Dayananth, Priya, Carr, Donna, Kirschmeier, Paul, Bishop, W Robert, Deng, Yongqi, Cooper, Alan, Shipps, Gerald W, Moreno, Blanca Homet, Robert, Lidia, Ribas, Antoni, Flaherty, Keith T

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Rethinking drug design in the artificial intelligence era von Schneider, Petra, Walters, W. Patrick, Plowright, Alleyn T., Sieroka, Norman, Listgarten, Jennifer, Goodnow, Robert A., Fisher, Jasmin, Jansen, Johanna M., Duca, José S., Rush, Thomas S., Zentgraf, Matthias, Hill, John Edward, Krutoholow, Elizabeth, Kohler, Matthias, Blaney, Jeff, Funatsu, Kimito, Luebkemann, Chris, Schneider, Gisbert

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The Role of Helix 1 Aspartates and Salt Bridges in the Stability and Conversion of Prion Protein von Speare, Jonathan O, Rush, 3rd, Thomas S, Bloom, Marshall E, Caughey, Byron

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Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor von Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T, Altman, Michael D, Rush, Thomas S, Cornea, Anda, Conn, P. Michael

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Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis von Hu, Yonghan, Xiang, Jason S., DiGrandi, Martin J., Du, Xuemei, Ipek, Manus, Laakso, Leif M., Li, Jianchang, Li, Wei, Rush, Thomas S., Schmid, Jean, Skotnicki, Jerauld S., Tam, Steve, Thomason, Jennifer R., Wang, Qin, Levin, Jeremy I.

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Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design von Tsao, Désirée H.H., Sutherland, Alan G., Jennings, Lee. D., Li, Yuanhong, Rush, Thomas S., Alvarez, Juan C., Ding, Weidong, Dushin, Elizabeth G., Dushin, Russell G., Haney, Steve A., Kenny, Cynthia H., Karl Malakian, A., Nilakantan, Ramaswamy, Mosyak, Lidia

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Machine Learning Models to Predict Inhibition of the Bile Salt Export Pump von McLoughlin, Kevin S, Jeong, Claire G, Sweitzer, Thomas D, Minnich, Amanda J, Tse, Margaret J, Bennion, Brian J, Allen, Jonathan E, Calad-Thomson, Stacie, Rush, Thomas S, Brase, James M

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Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction von Sutherland, Alan G, Alvarez, Juan, Ding, Weidong, Foreman, K W, Kenny, Cynthia Hess, Labthavikul, Pornpen, Mosyak, Lidia, Petersen, Peter J, Rush, 3rd, Thomas S, Ruzin, Alexey, Tsao, Desiree H H, Wheless, Karen L

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Identification of potent and selective MMP-13 inhibitors von Wu, Junjun, Rush, Thomas S., Hotchandani, Rajeev, Du, Xuemei, Geck, Mary, Collins, Elisabeth, Xu, Zhang-Bao, Skotnicki, Jerry, Levin, Jeremy I., Lovering, Frank E.

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Design and synthesis of indolo[2,3- a]quinolizin-7-one inhibitors of the ZipA–FtsZ interaction von Jennings, Lee D., Foreman, Ken W., Rush, Thomas S., Tsao, Desiree H.H., Mosyak, Lidia, Li, Yuanhong, Sukhdeo, Mohani N., Ding, Weidong, Dushin, Elizabeth G., Kenny, Cynthia Hess, Moghazeh, Soraya L., Petersen, Peter J., Ruzin, Alexey V., Tuckman, Margareta, Sutherland, Alan G.

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FeNO Structure in Distal Pocket Mutants of Myoglobin Based on Resonance Raman Spectroscopy von Coyle, Candace M, Vogel, Kathleen M, Rush, Thomas S, Kozlowski, Pawel M, Williams, Robert, Spiro, Thomas G, Dou, Yi, Ikeda-Saito, Masao, Olson, John S, Zgierski, Marek Z

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Impact of Mobility on Structure-Based Drug Design for the MMPs von Moy, Franklin J, Chanda, Pranab K, Chen, James, Cosmi, Scott, Edris, Wade, Levin, Jeremy I, Rush, Thomas S, Wilhelm, James, Powers, Robert

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Structure-Based Identification of the Binding Site for the Hemiasterlin Analogue HTI-286 on Tubulin von Ravi, Malini, Zask, Arie, Rush, Thomas S

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Synthesis and SAR of highly selective MMP-13 inhibitors von Li, Jianchang, Rush, Thomas S., Li, Wei, DeVincentis, Dianne, Du, Xuemei, Hu, Yonghan, Thomason, Jennifer R., Xiang, Jason S., Skotnicki, Jerauld S., Tam, Steve, Cunningham, Kristina M., Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

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IR spectra of cytochrome c denatured with deuterated guanidine hydrochloride show increase in β sheet von Speare, Jonathan O., Rush III, Thomas S.

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3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding von Li, Wei, Hu, Yonghan, Li, Jianchang, Thomason, Jennifer R., DeVincentis, Dianne, Du, Xuemei, Wu, Junjun, Hotchandani, Rajeev, Rush, Thomas S., Skotnicki, Jerauld S., Tam, Steve, Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

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Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA–FtsZ interaction von Jennings, Lee D., Foreman, Kenneth W., Rush, Thomas S., Tsao, Desiree H.H., Mosyak, Lidia, Kincaid, Scott L., Sukhdeo, Mohani N., Sutherland, Alan G., Ding, Weidong, Kenny, Cynthia Hess, Sabus, Chantel L., Liu, Hanlan, Dushin, Elizabeth G., Moghazeh, Soraya L., Labthavikul, Pornpen, Petersen, Peter J., Tuckman, Margareta, Ruzin, Alexey V.

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Alternative Modes of Substrate Distortion in Enzyme and Antibody Catalyzed Ferrochelation Reactions von Blackwood, Milton E, Rush, Thomas S, Romesberg, Floyd, Schultz, Peter G, Spiro, Thomas G

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