The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease von Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina

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Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors von Rueeger, Heinrich, Rondeau, Jean-Michel, McCarthy, Clive, Möbitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf, Desrayaud, Sandrine

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Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease von Machauer, Rainer, Lueoend, Rainer, Hurth, Konstanze, Veenstra, Siem J., Rueeger, Heinrich, Voegtle, Markus, Tintelnot-Blomley, Marina, Rondeau, Jean-Michel, Jacobson, Laura H., Laue, Grit, Beltz, Karen, Neumann, Ulf

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Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Pe... von Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf

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Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360 von Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem J, Holzer, Philipp, Hurth, Konstanze, Voegtle, Markus, Frederiksen, Mathias, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Jacobson, Laura H, Staufenbiel, Matthias, Laue, Grit, Neumann, Ulf

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Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor von Fairhurst, Robin A., Furet, Pascal, Imbach-Weese, Patricia, Stauffer, Frédéric, Rueeger, Heinrich, McCarthy, Clive, Ripoche, Sebastien, Oswald, Susanne, Arnaud, Bertrand, Jary, Aline, Maira, Michel, Schnell, Christian, Guthy, Daniel A., Wartmann, Markus, Kiffe, Michael, Desrayaud, Sandrine, Blasco, Francesca, Widmer, Toni, Seiler, Frank, Gutmann, Sascha, Knapp, Mark, Caravatti, Giorgio

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A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice von Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem Jacob, Lueoend, Rainer M, Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Schmid, Peter, Frieauff, Wilfried, Shimshek, Derya R, Staufenbiel, Matthias, Jacobson, Laura H

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Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors von Veenstra, Siem Jakob, Rueeger, Heinrich, Voegtle, Markus, Lueoend, Rainer, Holzer, Philipp, Hurth, Konstanze, Tintelnot-Blomley, Marina, Frederiksen, Mathias, Rondeau, Jean-Michel, Jacobson, Laura, Staufenbiel, Matthias, Neumann, Ulf, Machauer, Rainer

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BET bromodomain inhibitors regulate keratinocyte plasticity von Schutzius, Gabi, Kolter, Christian, Bergling, Sebastian, Tortelli, Federico, Fuchs, Florian, Renner, Steffen, Guagnano, Vito, Cotesta, Simona, Rueeger, Heinrich, Faller, Michael, Bouchez, Laure, Salathe, Adrian, Nigsch, Florian, Richards, Shola M., Louis, Malvina, Gruber, Viktoria, Aebi, Alexandra, Turner, Jonathan, Grandjean, Frederic, Li, Jun, Dimitri, Chris, Thomas, Jason R., Schirle, Markus, Blank, Jutta, Drueckes, Peter, Vaupel, Andrea, Tiedt, Ralph, Manley, Paul W., Klopp, Julia, Hemmig, Rene, Zink, Florence, Leroy, Nelly, Carbone, Walter, Roma, Guglielmo, Keller, Caroline Gubser, Dales, Natalie, Beyerbach, Armin, Zimmerlin, Alfred, Bonenfant, Debora, Terranova, Remi, Berwick, Amy, Sahambi, Sukhdeep, Reynolds, Aimee, Jennings, Lori L., Ruffner, Heinz, Tarsa, Peter, Bouwmeester, Tewis, Driver, Vickie, Frederiksen, Mathias, Lohmann, Felix, Kirkland, Susan

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Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-... von Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem Jacob, Jacobson, Laura Helen, Staufenbiel, Matthias, Desrayaud, Sandrine, Rondeau, Jean-Michel, Möbitz, Henrik, Neumann, Ulf

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Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application von Lerchner, Andreas, Machauer, Rainer, Betschart, Claudia, Veenstra, Siem, Rueeger, Heinrich, McCarthy, Clive, Tintelnot-Blomley, Marina, Jaton, Anne-Lise, Rabe, Sabine, Desrayaud, Sandrine, Enz, Albert, Staufenbiel, Matthias, Paganetti, Paolo, Rondeau, Jean-Michel, Neumann, Ulf

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Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors von Weihofen, Andreas, Lemberg, Marius K., Friedmann, Elena, Rueeger, Heinrich, Schmitz, Albert, Paganetti, Paolo, Rovelli, Giorgio, Martoglio, Bruno

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The BACE ‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease von Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina

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Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective I2-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid I... von Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Rondeau, Jean-Michel, Mobitz, Henrik, Neumann, Ulf

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A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-[beta] and neuroinflammation in APP transgenic mice von Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem Jacob, Lueoend, Rainer M, Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Schmid, Peter, Frieauff, Wilfried, Shimshek, Derya R, Staufenbiel, Matthias, Jacobson, Laura H

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P4‐363: THE BACE INHIBITOR NB‐360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID‐B LOAD IN ANIMAL MODELS von Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem, Lueoend, Rainer, Tintelnot‐Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Shimshek, Derya, Frieauff, Wilfried, Schmid, Peter, Staufenbiel, Matthias, Jacobson, Laura H.

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THE BACE INHIBITOR NB-360 HAS EXCELLENT BRAIN PENETRATION AND EFFICACY ON AMYLOID-B LOAD IN ANIMAL MODELS von Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem, Lueoend, Rainer, Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Shimshek, Derya, Frieauff, Wilfried, Schmid, Peter, Staufenbiel, Matthias, Jacobson, Laura H

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Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals von Dev, Kumlesh K., Chatterjee, Sandipan, Osinde, Maribel, Stauffer, Daniela, Morgan, Hannah, Kobialko, Monika, Dengler, Uwe, Rueeger, Heinrich, Martoglio, Bruno, Rovelli, Giorgio

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Discovery and SAR of potent, orally available and brain-penetrable 5,6-dihydro-4H-3-thia-1-aza-benzo[e]azulen- and 4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen derivatives as neur... von Rueeger, Heinrich, Gerspacher, Marc, Buehlmayer, Peter, Rigollier, Pascal, Yamaguchi, Yasuchika, Schmidlin, Tibur, Whitebread, Steven, Nuesslein-Hildesheim, Barbara, Nick, Hanspeter, Cricione, Leoluca

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inibidores de bace-2 para o tratamento de distúrbios metabólicos von HEINRICH RUEEGER

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