Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice von Foy, Susan P, Sennino, Barbara, dela Cruz, Tracy, Cote, Joseph J, Gordon, Evan J, Kemp, Felicia, Xavier, Veronica, Franzusoff, Alex, Rountree, Ryan B, Mandl, Stefanie J

Volltext

Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate von Kahn, Joy, Shwartz, Yulia, Blitz, Einat, Krief, Sharon, Sharir, Amnon, Breitel, Dario. A., Rattenbach, Revital, Relaix, Frederic, Maire, Pascal, Rountree, Ryan B., Kingsley, David M., Zelzer, Elazar

Volltext

BMP receptor signaling is required for postnatal maintenance of articular cartilage von Rountree, Ryan B, Schoor, Michael, Chen, Hao, Marks, Melissa E, Harley, Vincent, Mishina, Yuji, Kingsley, David M

Volltext

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis von Koyama, Eiki, Shibukawa, Yoshihiro, Nagayama, Motohiko, Sugito, Hiroki, Young, Blanche, Yuasa, Takahito, Okabe, Takahiro, Ochiai, Takanaga, Kamiya, Nobuhiko, Rountree, Ryan B., Kingsley, David M., Iwamoto, Masahiro, Enomoto-Iwamoto, Motomi, Pacifici, Maurizio

Volltext

Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy von ROUNTREE, Ryan B, MANDL, Stefanie J, DELCAYRE, Alain, NACHTWEY, James M, DALPOZZO, Katie, DO, Lisa, LOMBARDO, John R, SCHOONMAKER, Peter L, BRINKMANN, Kay, DIRMEIER, Ulrike, LAUS, Reiner

Volltext

Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes von Settle, Stephen H, Rountree, Ryan B, Sinha, Abhishek, Thacker, Abigail, Higgins, Kay, Kingsley, David M

Volltext

Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells von Foy, Susan P., Mandl, Stefanie J., dela Cruz, Tracy, Cote, Joseph J., Gordon, Evan J., Trent, Erica, Delcayre, Alain, Breitmeyer, James, Franzusoff, Alex, Rountree, Ryan B.

Volltext

Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling von Koyama, Eiki, Ochiai, Takanaga, Rountree, Ryan B, Kingsley, David M, Enomoto-Iwamoto, Motomi, Iwamoto, Masahiro, Pacifici, Maurizio

Volltext

810 NX-1607, a small molecule inhibitor of CBL-B, enhances anti-PD-1-mediated tumor growth inhibition by reshaping intratumoral innate and adaptive immune response von Gallotta, Marilena, Romo, Jose Gomez, Ranucci, Serena, Lee, Ernestine, Borodovsky, Alexandra, Hansen, Gwenn M, Sands, Arthur T, Rountree, Ryan, Guiducci, Cristiana

Volltext

Mineral Formation in Joints Caused by Complete or Joint‐Specific Loss of ANK Function von Gurley, Kyle A, Chen, Hao, Guenther, Catherine, Nguyen, Elizabeth T, Rountree, Ryan B, Schoor, Michael, Kingsley, David M

Volltext

RIP4 Regulates Epidermal Differentiation and Cutaneous Inflammation von Rountree, Ryan B., Willis, Cynthia R., Dinh, Huyen, Blumberg, Hal, Bailey, Keith, Dean, Charles, Peschon, Jacques J., Holland, Pamela M.

Volltext

The role of Irf6 in tooth epithelial invagination von Blackburn, James, Ohazama, Atsushi, Kawasaki, Katsushige, Otsuka-Tanaka, Yoko, Liu, Bigang, Honda, Kenya, Rountree, Ryan B., Hu, Yinling, Kawasaki, Maiko, Birchmeier, Walter, Schmidt-Ullrich, Ruth, Kinoshita, Akira, Schutte, Brian C., Hammond, Nigel L., Dixon, Michael J., Sharpe, Paul T.

Volltext

Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy von Mandl, Stefanie J, Rountree, Ryan B, Dela Cruz, Tracy B, Foy, Susan P, Cote, Joseph J, Gordon, Evan J, Trent, Erica, Delcayre, Alain, Franzusoff, Alex

Volltext

Immunotherapy with MVA-BN®-HER2 induces HER-2-specific Th1 immunity and alters the intratumoral balance of effector and regulatory T cells von Mandl, Stefanie J., Rountree, Ryan B., Dalpozzo, Katie, Do, Lisa, Lombardo, John R., Schoonmaker, Peter L., Dirmeier, Ulrike, Steigerwald, Robin, Giffon, Thierry, Laus, Reiner, Delcayre, Alain

Volltext

Poxvirus-based active immunotherapy synergizes with immune checkpoint inhibitors to cause tumor regression and extend survival in preclinical models of cancer von Foy, Susan P, Rountree, Ryan B, Cote, Joseph, dela Cruz, Tracy, Gordon, Evan, Trent, Erica, Franzusoff, Alex, Breitmeyer, James B, Mandl, Stefanie J

Volltext

Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B C... von Robbins, Daniel W., Noviski, Mark A., Tan, Ying Siow, Konst, Zef A., Kelly, Aileen, Auger, Paul, Brathaban, Nivetha, Cass, Robert, Chan, Ming Liang, Cherala, Ganesh, Clifton, Matthew C., Gajewski, Stefan, Ingallinera, Timothy G., Karr, Dane, Kato, Daisuke, Ma, Jun, McKinnell, Jenny, McIntosh, Joel, Mihalic, Jeff, Murphy, Brent, Panga, Jaipal Reddy, Peng, Ge, Powers, Janine, Perez, Luz, Rountree, Ryan, Tenn-McClellan, Austin, Sands, Arthur T., Weiss, Dahlia R., Wu, Jeffrey, Ye, Jordan, Guiducci, Cristiana, Hansen, Gwenn, Cohen, Frederick

Volltext

Abstract 1595: Small molecule inhibition of the ubiquitin ligase CBL-B results in potent T and NK cell mediated anti-tumor response von Rountree, Ryan, Cohen, Frederick, Tenn-McClellan, Austin, Borodovsky, Alexandra, Gallotta, Marilena, Stokes, Jennifer, Romo, Jose Gomez, Karim, Chris, Hansen, Gwenn M., Guiducci, Cristiana, Sands, Arthur, Gosling, Jennifa

Volltext

Nx-5948, a Selective Degrader of BTK with Activity in Preclinical Models of Hematologic and Brain Malignancies von Robbins, Daniel W, Noviski, Mark, Rountree, Ryan, Tan, May, Brathaban, Nivetha, Ingallinera, Timothy, Karr, Dane E, Kelly, Aileen, Konst, Zef, Ma, Jun, Tenn-McClellan, Austin, McKinnell, Jenny, Perez, Luz, Guiducci, Cristiana, Hansen, Gwenn, Sands, Arthur

Volltext

OTHR-02. CHIMERIC AURORA A KINASE (AURKA) DEGRADERS EFFICIENTLY TARGET N-MYC von Valinciute, Gintvile, Eing, Lorenz, Mihalic, Jeffrey, Casey, Colleen E, Tian, Hua, Adhikari, Bikash, Guiducci, Cristiana, Rountree, Ryan, Grohmann, Christoph, Sridharan, Sangita, Lu, Ya-Wen, Vezina-Dawod, Simon, Wegrzyniak, Eric, Chaterjee, Abhinav, Hansen, Gwenn M, Maris, John M, Mossé, Yael P, Eilers, Martin, Wolf, Elmar, Roussel, Martine F

Volltext

Nx-2127, a Degrader of BTK and IMiD Neosubstrates, for the Treatment of B-Cell Malignancies von Robbins, Daniel W, Kelly, Aileen, Tan, May, McIntosh, Joel, Wu, Jeffrey, Konst, Zef, Kato, Daisuke, Peng, Ge, Mihalic, Jeff, Weiss, Dahlia, Perez, Luz, Tung, Jennifer, Kolobova, Anna, Borodovsky, Sasha, Rountree, Ryan, Tenn-McClellan, Austin, Noviski, Mark, Ye, Jordan, Basham, Steve, Ingallinera, Timothy, McKinnell, Jenny, Karr, Dane E, Powers, Janine, Guiducci, Cristiana, Sands, Arthur

Volltext