A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition von Gong, Chang, Milberg, Oleg, Wang, Bing, Vicini, Paolo, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.

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Population Pharmacokinetics of Palivizumab, a Humanized Anti-Respiratory Syncytial Virus Monoclonal Antibody, in Adults and Children von Robbie, Gabriel J, Zhao, Liang, Mondick, John, Losonsky, Genevieve, Roskos, Lorin K

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Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice von Kijanka, Grzegorz, Bee, Jared S., Korman, Samuel A., Wu, Yuling, Roskos, Lorin K., Schenerman, Mark A., Slütter, Bram, Jiskoot, Wim

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Population Pharmacokinetic Modeling of Benralizumab in Adult and Adolescent Patients with Asthma von Yan, Li, Wang, Bing, Chia, Yen Lin, Roskos, Lorin K.

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A novel approach to assess domain specificity of anti-drug antibodies to moxetumomab pasudotox, an immunotoxin with two functional domains von Vainshtein, Inna, Sun, Bo, Roskos, Lorin K., Liang, Meina

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A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade von Milberg, Oleg, Gong, Chang, Jafarnejad, Mohammad, Bartelink, Imke H., Wang, Bing, Vicini, Paolo, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.

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Elimination mechanisms of therapeutic monoclonal antibodies von Tabrizi, Mohammad A., Tseng, Chih-Ming L., Roskos, Lorin K.

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Population Pharmacokinetics and Exposure–Response Analysis for the Phase 3 COSMIC-311 Trial of Cabozantinib for Radioiodine-Refractory Differentiated Thyroid Cancer von Ly, Neang S., Li, Jing, Faggioni, Raffaella, Roskos, Lorin K., Brose, Marcia S.

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Mechanistic modeling of a human IgG 4 monoclonal antibody (tralokinumab) Fab-arm exchange with endogenous IgG 4 in healthy volunteers von Wang, Bing, Goodman, Jo, Roskos, Lorin K

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Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis von Guo, Xiang, Higgs, Brandon W., Bay-Jensen, Anne C., Karsdal, Morten A., Yao, Yihong, Roskos, Lorin K., White, Wendy I.

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Mechanistic modeling of a human IgG4 monoclonal antibody (tralokinumab) Fab‐arm exchange with endogenous IgG4 in healthy volunteers von Wang, Bing, Goodman, Jo, Roskos, Lorin K.

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Excessive outlier removal may result in cut points that are not suitable for immunogenicity assessments von Kubiak, Robert J., Zhang, Jianchun, Ren, Pin, Yang, Harry, Roskos, Lorin K.

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A Computational Model of Neoadjuvant PD-1 Inhibition in Non-Small Cell Lung Cancer von Jafarnejad, Mohammad, Gong, Chang, Gabrielson, Edward, Bartelink, Imke H., Vicini, Paolo, Wang, Bing, Narwal, Rajesh, Roskos, Lorin, Popel, Aleksander S.

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Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody von Cheng, Jackie, Liang, Meina, Carvalho, Miguel F., Tigue, Natalie, Faggioni, Raffaella, Roskos, Lorin K., Vainshtein, Inna

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Immunogenicity assay cut point determination using nonparametric tolerance limit von Zhang, Jianchun, Li, Wenjia, Roskos, Lorin K., Yang, Harry

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From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice von Jakobovits, Aya, Amado, Rafael G, Yang, Xiaodong, Roskos, Lorin, Schwab, Gisela

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Population Pharmacokinetics of Sifalimumab, an Investigational Anti-Interferon-α Monoclonal Antibody, in Systemic Lupus Erythematosus von Narwal, Rajesh, Roskos, Lorin K., Robbie, Gabriel J.

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A new method for identification of outliers in immunogenicity assay cut point data von Zhang, Jianchun, Arends, Rosalin HGP, Kubiak, Robert J, Roskos, Lorin K, Liang, Meina, Lee, Nancy, Chen, Cecil Chi-Keung, Yang, Harry

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Prevalence of IgG and Neutralizing Antibodies Against Staphylococcus aureus Alpha Toxin in Healthy Human Subjects and Diverse Patient Populations von Wu, Yuling, Liu, Xu, Akhgar, Ahmad, Li, Jia J, Mok, Hoyin, Sellman, Bret R, Yu, Li, Roskos, Lorin K, Esser, Mark T, Ruzin, Alexey

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Combining pharmacometric models with predictive and prognostic biomarkers for precision therapy in Crohn's disease: A case study of brazikumab von Zhang, Nan, Chan, Ming Liang, Li, Jing, Brohawn, Philip Z., Sun, Bo, Vainshtein, Inna, Roskos, Lorin K., Faggioni, Raffaella, Savic, Rada M.

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