Tumor adaptation and resistance to RAF inhibitors von Lito, Piro, Rosen, Neal, Solit, David B

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Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism von Lito, Piro, Solomon, Martha, Li, Lian-Sheng, Hansen, Rasmus, Rosen, Neal

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Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway von Li, Zhiqiang, Razavi, Pedram, Li, Qing, Toy, Weiyi, Liu, Bo, Ping, Christina, Hsieh, Wilson, Sanchez-Vega, Francisco, Brown, David N., Da Cruz Paula, Arnaud F., Morris, Luc, Selenica, Pier, Eichenberger, Emily, Shen, Ronglai, Schultz, Nikolaus, Rosen, Neal, Scaltriti, Maurizio, Brogi, Edi, Baselga, Jose, Reis-Filho, Jorge S., Chandarlapaty, Sarat

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Mutant-selective degradation by BRAF-targeting PROTACs von Alabi, Shanique, Jaime-Figueroa, Saul, Yao, Zhan, Gao, Yijun, Hines, John, Samarasinghe, Kusal T. G., Vogt, Lea, Rosen, Neal, Crews, Craig M.

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis von Mukherjee, Radha, Vanaja, Kiran G, Boyer, Jacob A, Gadal, Sunyana, Solomon, Hilla, Chandarlapaty, Sarat, Levchenko, Andre, Rosen, Neal

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Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer von Yaeger, Rona, Chatila, Walid K., Lipsyc, Marla D., Hechtman, Jaclyn F., Cercek, Andrea, Sanchez-Vega, Francisco, Jayakumaran, Gowtham, Middha, Sumit, Zehir, Ahmet, Donoghue, Mark T.A., You, Daoqi, Viale, Agnes, Kemeny, Nancy, Segal, Neil H., Stadler, Zsofia K., Varghese, Anna M., Kundra, Ritika, Gao, Jianjiong, Syed, Aijazuddin, Hyman, David M., Vakiani, Efsevia, Rosen, Neal, Taylor, Barry S., Ladanyi, Marc, Berger, Michael F., Solit, David B., Shia, Jinru, Saltz, Leonard, Schultz, Nikolaus

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A combinatorial strategy for treating KRAS-mutant lung cancer von Manchado, Eusebio, Weissmueller, Susann, Morris, John P., Chen, Chi-Chao, Wullenkord, Ramona, Lujambio, Amaia, de Stanchina, Elisa, Poirier, John T., Gainor, Justin F., Corcoran, Ryan B., Engelman, Jeffrey A., Rudin, Charles M., Rosen, Neal, Lowe, Scott W.

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Acquired BRAF Rearrangements Induce Secondary Resistance to EGFR therapy in EGFR-Mutated Lung Cancers von Vojnic, Morana, Kubota, Daisuke, Kurzatkowski, Christopher, Offin, Michael, Suzawa, Ken, Benayed, Ryma, Schoenfeld, Adam J., Plodkowski, Andrew J., Poirier, John T., Rudin, Charles M., Kris, Mark G., Rosen, Neal X., Yu, Helena A., Riely, Gregory J., Arcila, Maria E., Somwar, Romel, Ladanyi, Marc

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PTEN is a protein tyrosine phosphatase for IRS1 von Shi, Yuji, Wang, Junru, Chandarlapaty, Sarat, Cross, Justin, Thompson, Craig, Rosen, Neal, Jiang, Xuejun

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Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors von Lito, Piro, Saborowski, Anna, Yue, Jingyin, Solomon, Martha, Joseph, Eric, Gadal, Sunyana, Saborowski, Michael, Kastenhuber, Edward, Fellmann, Christof, Ohara, Kazuhiro, Morikami, Kenji, Miura, Takaaki, Lukacs, Christine, Ishii, Nobuya, Lowe, Scott, Rosen, Neal

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RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling von Yao, Zhan, Gao, Yijun, Su, Wenjing, Yaeger, Rona, Tao, Jessica, Na, Na, Zhang, Ying, Zhang, Chao, Rymar, Andrey, Tao, Anthony, Timaul, Neilawattie M., Mcgriskin, Rory, Outmezguine, Nathaniel A., Zhao, HuiYong, Chang, Qing, Qeriqi, Besnik, Barbacid, Mariano, de Stanchina, Elisa, Hyman, David M, Bollag, Gideon, Rosen, Neal

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Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer von Carver, Brett S., Chapinski, Caren, Wongvipat, John, Hieronymus, Haley, Chen, Yu, Chandarlapaty, Sarat, Arora, Vivek K., Le, Carl, Koutcher, Jason, Scher, Howard, Scardino, Peter T., Rosen, Neal, Sawyers, Charles L.

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Accelerating Discovery of Functional Mutant Alleles in Cancer von Chang, Matthew T, Bhattarai, Tripti Shrestha, Schram, Alison M, Bielski, Craig M, Donoghue, Mark T A, Jonsson, Philip, Chakravarty, Debyani, Phillips, Sarah, Kandoth, Cyriac, Penson, Alexander, Gorelick, Alexander, Shamu, Tambudzai, Patel, Swati, Harris, Christopher, Gao, JianJiong, Sumer, Selcuk Onur, Kundra, Ritika, Razavi, Pedram, Li, Bob T, Reales, Dalicia N, Socci, Nicholas D, Jayakumaran, Gowtham, Zehir, Ahmet, Benayed, Ryma, Arcila, Maria E, Chandarlapaty, Sarat, Ladanyi, Marc, Schultz, Nikolaus, Baselga, José, Berger, Michael F, Rosen, Neal, Solit, David B, Hyman, David M, Taylor, Barry S

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) von Poulikakos, Poulikos I., Persaud, Yogindra, Janakiraman, Manickam, Kong, Xiangju, Ng, Charles, Moriceau, Gatien, Shi, Hubing, Atefi, Mohammad, Titz, Bjoern, Gabay, May Tal, Salton, Maayan, Dahlman, Kimberly B., Tadi, Madhavi, Wargo, Jennifer A., Flaherty, Keith T., Kelley, Mark C., Misteli, Tom, Chapman, Paul B., Sosman, Jeffrey A., Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Rosen, Neal, Solit, David B.

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Pilot trial of combined BRAF and EGFR inhibition in BRAF-mutant metastatic colorectal cancer patients von Yaeger, Rona, Cercek, Andrea, O'Reilly, Eileen M, Reidy, Diane L, Kemeny, Nancy, Wolinsky, Tamar, Capanu, Marinela, Gollub, Marc J, Rosen, Neal, Berger, Michael F, Lacouture, Mario E, Vakiani, Efsevia, Saltz, Leonard B

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HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway von Smith, Alison E., Ferraro, Emanuela, Safonov, Anton, Morales, Cristina Bernado, Lahuerta, Enrique J. Arenas, Li, Qing, Kulick, Amanda, Ross, Dara, Solit, David B., de Stanchina, Elisa, Reis-Filho, Jorge, Rosen, Neal, Arribas, Joaquín, Razavi, Pedram, Chandarlapaty, Sarat

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INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors von Li, Qing, Jiang, Baishan, Guo, Jiaye, Shao, Hong, Del Priore, Isabella S, Chang, Qing, Kudo, Rei, Li, Zhiqiang, Razavi, Pedram, Liu, Bo, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Donovan, Katherine A, Palafox, Marta, Reis-Filho, Jorge S, de Stanchina, Elisa, Fischer, Eric S, Rosen, Neal, Serra, Violeta, Koff, Andrew, Chodera, John D, Gray, Nathanael S, Chandarlapaty, Sarat

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Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer von Tricker, Erin M, Xu, Chunxiao, Uddin, Sharmeen, Capelletti, Marzia, Ercan, Dalia, Ogino, Atsuko, Pratilas, Christine A, Rosen, Neal, Gray, Nathanael S, Wong, Kwok-Kin, Jänne, Pasi A

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V⁶⁰⁰EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway von Pratilas, Christine A, Taylor, Barry S, Ye, Qing, Viale, Agnes, Sander, Chris, Solit, David B, Rosen, Neal

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling von Rodrik-Outmezguine, Vanessa S, Chandarlapaty, Sarat, Pagano, Nen C, Poulikakos, Poulikos I, Scaltriti, Maurizio, Moskatel, Elizabeth, Baselga, José, Guichard, Sylvie, Rosen, Neal

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