Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities von Sanson, Kendall R., Hanna, Ruth E., Hegde, Mudra, Donovan, Katherine F., Strand, Christine, Sullender, Meagan E., Vaimberg, Emma W., Goodale, Amy, Root, David E., Piccioni, Federica, Doench, John G.

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells von Shalem, Ophir, Sanjana, Neville E., Hartenian, Ella, Shi, Xi, Scott, David A., Mikkelsen, Tarjei S., Heckl, Dirk, Ebert, Benjamin L., Root, David E., Doench, John G., Zhang, Feng

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Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects von Dempster, Joshua M, Boyle, Isabella, Vazquez, Francisca, Root, David E, Boehm, Jesse S, Hahn, William C, Tsherniak, Aviad, McFarland, James M

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Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation von Doench, John G, Hartenian, Ella, Graham, Daniel B, Tothova, Zuzana, Hegde, Mudra, Smith, Ian, Sullender, Meagan, Ebert, Benjamin L, Xavier, Ramnik J, Root, David E

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A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation von Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.

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Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map von Smith, Ian, Greenside, Peyton G, Natoli, Ted, Lahr, David L, Wadden, David, Tirosh, Itay, Narayan, Rajiv, Root, David E, Golub, Todd R, Subramanian, Aravind, Doench, John G

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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis von Rosenbluh, Joseph, Nijhawan, Deepak, Cox, Andrew G., Li, Xingnan, Neal, James T., Schafer, Eric J., Zack, Travis I., Wang, Xiaoxing, Tsherniak, Aviad, Schinzel, Anna C., Shao, Diane D., Schumacher, Steven E., Weir, Barbara A., Vazquez, Francisca, Cowley, Glenn S., Root, David E., Mesirov, Jill P., Beroukhim, Rameen, Kuo, Calvin J., Goessling, Wolfram, Hahn, William C.

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KRAS and YAP1 Converge to Regulate EMT and Tumor Survival von Shao, Diane D., Xue, Wen, Krall, Elsa B., Bhutkar, Arjun, Piccioni, Federica, Wang, Xiaoxing, Schinzel, Anna C., Sood, Sabina, Rosenbluh, Joseph, Kim, Jong W., Zwang, Yaara, Roberts, Thomas M., Root, David E., Jacks, Tyler, Hahn, William C.

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Mutational processes shape the landscape of TP53 mutations in human cancer von Giacomelli, Andrew O., Yang, Xiaoping, Lintner, Robert E., McFarland, James M., Duby, Marc, Kim, Jaegil, Howard, Thomas P., Takeda, David Y., Ly, Seav Huong, Kim, Eejung, Gannon, Hugh S., Hurhula, Brian, Sharpe, Ted, Goodale, Amy, Fritchman, Briana, Steelman, Scott, Vazquez, Francisca, Tsherniak, Aviad, Aguirre, Andrew J., Doench, John G., Piccioni, Federica, Roberts, Charles W. M., Meyerson, Matthew, Getz, Gad, Johannessen, Cory M., Root, David E., Hahn, William C.

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Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration von McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad

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(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible von Losman, Julie-Aurore, Looper, Ryan E., Koivunen, Peppi, Lee, Sungwoo, Schneider, Rebekka K., McMahon, Christine, Cowley, Glenn S., Root, David E., Ebert, Benjamin L., Kaelin, William G.

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Identification of an oncogenic RAB protein von Wheeler, Douglas B., Zoncu, Roberto, Root, David E., Sabatini, David M., Sawyers, Charles L.

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DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells von He, Yizhou Joseph, Meghani, Khyati, Caron, Marie-Christine, Yang, Chunyu, Ronato, Daryl A., Bian, Jie, Sharma, Anchal, Moore, Jessica, Niraj, Joshi, Detappe, Alexandre, Doench, John G., Legube, Gaelle, Root, David E., D’Andrea, Alan D., Drané, Pascal, De, Subhajyoti, Konstantinopoulos, Panagiotis A., Masson, Jean-Yves, Chowdhury, Dipanjan

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lincRNAs act in the circuitry controlling pluripotency and differentiation von Guttman, Mitchell, Donaghey, Julie, Carey, Bryce W., Garber, Manuel, Grenier, Jennifer K., Munson, Glen, Young, Geneva, Lucas, Anne Bergstrom, Ach, Robert, Bruhn, Laurakay, Yang, Xiaoping, Amit, Ido, Meissner, Alexander, Regev, Aviv, Rinn, John L., Root, David E., Lander, Eric S.

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Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets von Dempster, Joshua M., Pacini, Clare, Pantel, Sasha, Behan, Fiona M., Green, Thomas, Krill-Burger, John, Beaver, Charlotte M., Younger, Scott T., Zhivich, Victor, Najgebauer, Hanna, Allen, Felicity, Gonçalves, Emanuel, Shepherd, Rebecca, Doench, John G., Yusa, Kosuke, Vazquez, Francisca, Parts, Leopold, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco

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Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting von Aguirre, Andrew J, Meyers, Robin M, Weir, Barbara A, Vazquez, Francisca, Zhang, Cheng-Zhong, Ben-David, Uri, Cook, April, Ha, Gavin, Harrington, William F, Doshi, Mihir B, Kost-Alimova, Maria, Gill, Stanley, Xu, Han, Ali, Levi D, Jiang, Guozhi, Pantel, Sasha, Lee, Yenarae, Goodale, Amy, Cherniack, Andrew D, Oh, Coyin, Kryukov, Gregory, Cowley, Glenn S, Garraway, Levi A, Stegmaier, Kimberly, Roberts, Charles W, Golub, Todd R, Meyerson, Matthew, Root, David E, Tsherniak, Aviad, Hahn, William C

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Cancer Vulnerabilities Unveiled by Genomic Loss von Nijhawan, Deepak, Zack, Travis I., Ren, Yin, Strickland, Matthew R., Lamothe, Rebecca, Schumacher, Steven E., Tsherniak, Aviad, Besche, Henrike C., Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A., Goldberg, Alfred L., Mesirov, Jill P., Root, David E., Bhatia, Sangeeta N., Beroukhim, Rameen, Hahn, William C.

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High-throughput Phenotyping of Lung Cancer Somatic Mutations von Berger, Alice H., Brooks, Angela N., Wu, Xiaoyun, Shrestha, Yashaswi, Chouinard, Candace, Piccioni, Federica, Bagul, Mukta, Kamburov, Atanas, Imielinski, Marcin, Hogstrom, Larson, Zhu, Cong, Yang, Xiaoping, Pantel, Sasha, Sakai, Ryo, Watson, Jacqueline, Kaplan, Nathan, Campbell, Joshua D., Singh, Shantanu, Root, David E., Narayan, Rajiv, Natoli, Ted, Lahr, David L., Tirosh, Itay, Tamayo, Pablo, Getz, Gad, Wong, Bang, Doench, John, Subramanian, Aravind, Golub, Todd R., Meyerson, Matthew, Boehm, Jesse S.

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A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering von To, Tsz-Leung, Cuadros, Alejandro M., Shah, Hardik, Hung, Wendy H.W., Li, Yang, Kim, Sharon H., Rubin, Daniel H.F., Boe, Ryan H., Rath, Sneha, Eaton, John K., Piccioni, Federica, Goodale, Amy, Kalani, Zohra, Doench, John G., Root, David E., Schreiber, Stuart L., Vafai, Scott B., Mootha, Vamsi K.

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A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer von Wilson, Frederick H., Johannessen, Cory M., Piccioni, Federica, Tamayo, Pablo, Kim, Jong Wook, Van Allen, Eliezer M., Corsello, Steven M., Capelletti, Marzia, Calles, Antonio, Butaney, Mohit, Sharifnia, Tanaz, Gabriel, Stacey B., Mesirov, Jill P., Hahn, William C., Engelman, Jeffrey A., Meyerson, Matthew, Root, David E., Jänne, Pasi A., Garraway, Levi A.

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