Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders von Chaudhary, Divya, Robinson, Shaughnessy, Romero, Donna L

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Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field von Wang, Lingle, Wu, Yujie, Deng, Yuqing, Kim, Byungchan, Pierce, Levi, Krilov, Goran, Lupyan, Dmitry, Robinson, Shaughnessy, Dahlgren, Markus K, Greenwood, Jeremy, Romero, Donna L, Masse, Craig, Knight, Jennifer L, Steinbrecher, Thomas, Beuming, Thijs, Damm, Wolfgang, Harder, Ed, Sherman, Woody, Brewer, Mark, Wester, Ron, Murcko, Mark, Frye, Leah, Farid, Ramy, Lin, Teng, Mobley, David L, Jorgensen, William L, Berne, Bruce J, Friesner, Richard A, Abel, Robert

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Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy von Kelly, Priscilla N, Romero, Donna L, Yang, Yibin, Shaffer, 3rd, Arthur L, Chaudhary, Divya, Robinson, Shaughnessy, Miao, Wenyan, Rui, Lixin, Westlin, William F, Kapeller, Rosana, Staudt, Louis M

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Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279 von Leit, Silvana, Greenwood, Jeremy, Carriero, Samantha, Mondal, Sayan, Abel, Robert, Ashwell, Mark, Blanchette, Heather, Boyles, Nicholas A., Cartwright, Mark, Collis, Alan, Feng, Shulu, Ghanakota, Phani, Harriman, Geraldine C., Hosagrahara, Vinayak, Kaila, Neelu, Kapeller, Rosanna, Rafi, Salma B., Romero, Donna L., Tarantino, Paul M., Timaniya, Jignesh, Toms, Angela V., Wester, Ronald T., Westlin, William, Srivastava, Bhaskar, Miao, Wenyan, Tummino, Peter, McElwee, Joshua J., Edmondson, Scott D., Masse, Craig E.

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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhib... von Baldwin, Eric T., Götte, Matthias, Tchesnokov, Egor P., Arnold, Eddy, Hagel, Margit, Nichols, Charles, Dossang, Pam, Lamers, Marieke, Wan, Paul, Steinbacher, Stefan, Romero, Donna L.

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Structures, functions and adaptations of the human LINE-1 ORF2 protein von Baldwin, Eric T., van Eeuwen, Trevor, Hoyos, David, Zalevsky, Arthur, Tchesnokov, Egor P., Sánchez, Roberto, Miller, Bryant D., Di Stefano, Luciano H., Ruiz, Francesc Xavier, Hancock, Matthew, Işik, Esin, Mendez-Dorantes, Carlos, Walpole, Thomas, Nichols, Charles, Wan, Paul, Riento, Kirsi, Halls-Kass, Rowan, Augustin, Martin, Lammens, Alfred, Jestel, Anja, Upla, Paula, Xibinaku, Kera, Congreve, Samantha, Hennink, Maximiliaan, Rogala, Kacper B., Schneider, Anna M., Fairman, Jennifer E., Christensen, Shawn M., Desrosiers, Brian, Bisacchi, Gregory S., Saunders, Oliver L., Hafeez, Nafeeza, Miao, Wenyan, Kapeller, Rosana, Zaller, Dennis M., Sali, Andrej, Weichenrieder, Oliver, Burns, Kathleen H., Götte, Matthias, Rout, Michael P., Arnold, Eddy, Greenbaum, Benjamin D., Romero, Donna L., LaCava, John, Taylor, Martin S.

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders von Gurney, Mark E, Nugent, Richard A, Mo, Xuesheng, Sindac, Janice A, Hagen, Timothy J, Fox, David, O’Donnell, James M, Zhang, Chong, Xu, Ying, Zhang, Han-Ting, Groppi, Vincent E, Bailie, Marc, White, Ronald E, Romero, Donna L, Vellekoop, A. Samuel, Walker, Joel R, Surman, Matthew D, Zhu, Lei, Campbell, Robert F

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Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis von Leit, Silvana, Greenwood, Jeremy R., Mondal, Sayan, Carriero, Samantha, Dahlgren, Markus, Harriman, Geraldine C., Kennedy-Smith, Joshua J., Kapeller, Rosana, Lawson, Jon P., Romero, Donna L., Toms, Angela V., Shelley, Mee, Wester, Ronald T., Westlin, William, McElwee, Joshua J., Miao, Wenyan, Edmondson, Scott D., Masse, Craig E.

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Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes von Moadab, Fatemeh, Sohrabi, Sepideh, Wang, Xiaoxing, Najjar, Rayan, Wolters, Justina C, Jiang, Hua, Miao, Wenyan, Romero, Donna, Zaller, Dennis M, Tran, Megan, Bays, Alison, Taylor, Martin S, Kapeller, Rosana, LaCava, John, Mustelin, Tomas

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Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR o... von Genin, Michael J, Biles, Carolyn, Keiser, Barb J, Poppe, Susan M, Swaney, Steven M, Tarpley, W. Gary, Yagi, Yoshihiko, Romero, Donna L

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A Stereoselective Intramolecular 1,3-Dipolar Nitrone Cycloaddition for the Synthesis of Substituted Chromanes von Zhao, Qian, Han, Fusen, Romero, Donna L

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Human serum albumin binding assay based on displacement of a non selective fluorescent inhibitor von Thorarensen, Atli, Sarver, Ronald W., Tian, Fang, Ho, Andrea, Romero, Donna L., Marotti, Keith R.

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PAS Kinase Drives Lipogenesis through SREBP-1 Maturation von Wu, Xiaoying, Romero, Donna, Swiatek, Wojciech I., Dorweiler, Irene, Kikani, Chintan K., Sabic, Hana, Zweifel, Ben S., McKearn, John, Blitzer, Jeremy T., Nickols, G. Allen, Rutter, Jared

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Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis von Mott, John E., Shaw, Bailin A., Smith, James F., Bonin, Paul D., Romero, Donna L., Marotti, Keith R., Miller, Alita A.

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Pd-Catalyzed Cycloisomerization to 1,2-Dialkylidenecycloalkanes. 2. Alternative Catalyst System von Trost, Barry M, Romero, Donna L, Rise, Frode

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Discovery and initial development of a novel class of antibacterials: Inhibitors of Staphylococcus aureus transcription/translation von Larsen, Scott D., Hester, Matthew R., Craig Ruble, J., Kamilar, Gregg M., Romero, Donna L., Wakefield, Brian, Melchior, Earline P., Sweeney, Michael T., Marotti, Keith R.

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Structure–activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors von Ruble, J. Craig, Wakefield, Brian D., Kamilar, Gregg M., Marotti, Keith R., Melchior, Earline, Sweeney, Michael T., Zurenko, Gary E., Romero, Donna L.

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Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics von STIFF, Cory, GRABER, David R, ROMERO, Donna L, THORARENSEN, Atli, WAKEFIELD, Brian D, MAROTTI, Keith R, MELCHIOR, Earline P, SWEENEY, Michael T, HAN, Fusen, ROHRER, Douglas C, ZURENKO, Gary E

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Preparation of novel anthranilic acids as antibacterial agents. Extensive evaluation of alternative amide bioisosteres connecting the A- and the B-rings von Thorarensen, Atli, Wakefield, Brian D., Romero, Donna L., Marotti, Keith R., Sweeney, Michael T., Zurenko, Gary E., Rohrer, Douglas C., Han, Fusen, Bryant, Garold L.

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Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin‑1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders:... von Chaudhary, Divya, Robinson, Shaughnessy, Romero, Donna L.

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