Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies von Lipson, Doron, Capelletti, Marzia, Yelensky, Roman, Otto, Geoff, Parker, Alex, Jarosz, Mirna, Curran, John A, Balasubramanian, Sohail, Bloom, Troy, Brennan, Kristina W, Donahue, Amy, Downing, Sean R, Frampton, Garrett M, Garcia, Lazaro, Juhn, Frank, Mitchell, Kathy C, White, Emily, White, Jared, Zwirko, Zac, Peretz, Tamar, Nechushtan, Hovav, Soussan-Gutman, Lior, Kim, Jhingook, Sasaki, Hidefumi, Kim, Hyeong Ryul, Park, Seung-il, Ercan, Dalia, Sheehan, Christine E, Ross, Jeffrey S, Cronin, Maureen T, Jänne, Pasi A, Stephens, Philip J

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Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial von Swisher, Elizabeth M, Dr Prof, Lin, Kevin K, PhD, Oza, Amit M, Prof, Scott, Clare L, PhD, Giordano, Heidi, MA, Sun, James, PhD, Konecny, Gottfried E, MD, Coleman, Robert L, Prof, Tinker, Anna V, MD, O'Malley, David M, MD, Kristeleit, Rebecca S, MD, Ma, Ling, MD, Bell-McGuinn, Katherine M, MD, Brenton, James D, Prof, Cragun, Janiel M, MD, Oaknin, Ana, MD, Ray-Coquard, Isabelle, Prof, Harrell, Maria I, PhD, Mann, Elaina, MS, Kaufmann, Scott H, Prof, Floquet, Anne, MD, Leary, Alexandra, MD, Harding, Thomas C, PhD, Goble, Sandra, MS, Maloney, Lara, BA, Isaacson, Jeff, PhD, Allen, Andrew R, MD, Rolfe, Lindsey, MBChB, Yelensky, Roman, PhD, Raponi, Mitch, PhD, McNeish, Iain A, Prof

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Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing von Frampton, Garrett M, Fichtenholtz, Alex, Otto, Geoff A, Wang, Kai, Downing, Sean R, He, Jie, Schnall-Levin, Michael, White, Jared, Sanford, Eric M, An, Peter, Sun, James, Juhn, Frank, Brennan, Kristina, Iwanik, Kiel, Maillet, Ashley, Buell, Jamie, White, Emily, Zhao, Mandy, Balasubramanian, Sohail, Terzic, Selmira, Richards, Tina, Banning, Vera, Garcia, Lazaro, Mahoney, Kristen, Zwirko, Zac, Donahue, Amy, Beltran, Himisha, Mosquera, Juan Miguel, Rubin, Mark A, Dogan, Snjezana, Hedvat, Cyrus V, Berger, Michael F, Pusztai, Lajos, Lechner, Matthias, Boshoff, Chris, Jarosz, Mirna, Vietz, Christine, Parker, Alex, Miller, Vincent A, Ross, Jeffrey S, Curran, John, Cronin, Maureen T, Stephens, Philip J, Lipson, Doron, Yelensky, Roman

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A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal von Sun, James X, He, Yuting, Sanford, Eric, Montesion, Meagan, Frampton, Garrett M, Vignot, Stéphane, Soria, Jean-Charles, Ross, Jeffrey S, Miller, Vincent A, Stephens, Phil J, Lipson, Doron, Yelensky, Roman

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Estimation of the multiple testing burden for genomewide association studies of nearly all common variants von Pe'er, Itsik, Yelensky, Roman, Altshuler, David, Daly, Mark J.

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The distribution of BRAF gene fusions in solid tumors and response to targeted therapy von Ross, Jeffrey S., Wang, Kai, Chmielecki, Juliann, Gay, Laurie, Johnson, Adrienne, Chudnovsky, Jacob, Yelensky, Roman, Lipson, Doron, Ali, Siraj M, Elvin, Julia A., Vergilio, Jo‐Anne, Roels, Steven, Miller, Vincent A, Nakamura, Brooke N., Gray, Adam, Wong, Michael K, Stephens, Philip J

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Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study von Wheler, Jennifer J, Janku, Filip, Naing, Aung, Li, Yali, Stephen, Bettzy, Zinner, Ralph, Subbiah, Vivek, Fu, Siqing, Karp, Daniel, Falchook, Gerald S, Tsimberidou, Apostolia M, Piha-Paul, Sarina, Anderson, Roosevelt, Ke, Danxia, Miller, Vincent, Yelensky, Roman, Lee, J Jack, Hong, David S, Kurzrock, Razelle

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Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors von Frampton, Garrett M, Ali, Siraj M, Rosenzweig, Mark, Chmielecki, Juliann, Lu, Xinyuan, Bauer, Todd M, Akimov, Mikhail, Bufill, Jose A, Lee, Carrie, Jentz, David, Hoover, Rick, Ou, Sai-Hong Ignatius, Salgia, Ravi, Brennan, Tim, Chalmers, Zachary R, Jaeger, Savina, Huang, Alan, Elvin, Julia A, Erlich, Rachel, Fichtenholtz, Alex, Gowen, Kyle A, Greenbowe, Joel, Johnson, Adrienne, Khaira, Depinder, McMahon, Caitlin, Sanford, Eric M, Roels, Steven, White, Jared, Greshock, Joel, Schlegel, Robert, Lipson, Doron, Yelensky, Roman, Morosini, Deborah, Ross, Jeffrey S, Collisson, Eric, Peters, Malte, Stephens, Philip J, Miller, Vincent A

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Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity von Beltran, Himisha, Yelensky, Roman, Frampton, Garrett M, Park, Kyung, Downing, Sean R, MacDonald, Theresa Y, Jarosz, Mirna, Lipson, Doron, Tagawa, Scott T, Nanus, David M, Stephens, Philip J, Mosquera, Juan Miguel, Cronin, Maureen T, Rubin, Mark A

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New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next‐Generation Sequencing von Ross, Jeffrey S., Wang, Kai, Gay, Laurie, Al‐Rohil, Rami, Rand, Janne V., Jones, David M., Lee, Hwa J., Sheehan, Christine E., Otto, Geoff A., Palmer, Gary, Yelensky, Roman, Lipson, Doron, Morosini, Deborah, Hawryluk, Matthew, Catenacci, Daniel V. T., Miller, Vincent A., Churi, Chaitanya, Ali, Siraj, Stephens, Philip J.

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Efficiency and power in genetic association studies von Daly, Mark J, Altshuler, David, de Bakker, Paul I W, Yelensky, Roman, Pe'er, Itsik, Gabriel, Stacey B

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Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms von Rampal, Raajit, Ahn, Jihae, Abdel-Wahab, Omar, Nahas, Michelle, Wang, Kai, Lipson, Doron, Otto, Geoff A, Yelensky, Roman, Hricik, Todd, McKenney, Anna Sophia, Chiosis, Gabriela, Chung, Young Rock, Pandey, Suveg, van den Brink, Marcel R M, Armstrong, Scott A, Dogan, Ahmet, Intlekofer, Andrew, Manshouri, Taghi, Park, Christopher Y, Verstovsek, Srdan, Rapaport, Franck, Stephens, Philip J, Miller, Vincent A, Levine, Ross L

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Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib von Wong, Victor, Pavlick, Dean, Brennan, Tim, Yelensky, Roman, Crawford, John, Ross, Jeffrey S, Miller, Vincent A, Malicki, Denise, Stephens, Philip J, Ali, Siraj M, Ahn, Hyunah

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Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets von Balko, Justin M, Giltnane, Jennifer M, Wang, Kai, Schwarz, Luis J, Young, Christian D, Cook, Rebecca S, Owens, Phillip, Sanders, Melinda E, Kuba, Maria G, Sánchez, Violeta, Kurupi, Richard, Moore, Preston D, Pinto, Joseph A, Doimi, Franco D, Gómez, Henry, Horiuchi, Dai, Goga, Andrei, Lehmann, Brian D, Bauer, Joshua A, Pietenpol, Jennifer A, Ross, Jeffrey S, Palmer, Gary A, Yelensky, Roman, Cronin, Maureen, Miller, Vincent A, Stephens, Phillip J, Arteaga, Carlos L

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Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400 von Herbst, Roy S, Gandara, David R, Hirsch, Fred R, Redman, Mary W, LeBlanc, Michael, Mack, Philip C, Schwartz, Lawrence H, Vokes, Everett, Ramalingam, Suresh S, Bradley, Jeffrey D, Sparks, Dana, Zhou, Yang, Miwa, Crystal, Miller, Vincent A, Yelensky, Roman, Li, Yali, Allen, Jeff D, Sigal, Ellen V, Wholley, David, Sigman, Caroline C, Blumenthal, Gideon M, Malik, Shakun, Kelloff, Gary J, Abrams, Jeffrey S, Blanke, Charles D, Papadimitrakopoulou, Vassiliki A

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Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes von Chmielecki, Juliann, Hutchinson, Katherine E, Frampton, Garrett M, Chalmers, Zachary R, Johnson, Adrienne, Shi, Chanjuan, Elvin, Julia, Ali, Siraj M, Ross, Jeffrey S, Basturk, Olca, Balasubramanian, Sohail, Lipson, Doron, Yelensky, Roman, Pao, William, Miller, Vincent A, Klimstra, David S, Stephens, Philip J

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Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations von Ross, Jeffrey S., Wang, Kai, Khaira, Depinder, Ali, Siraj M., Fisher, Huge A.G., Mian, Badar, Nazeer, Tipu, Elvin, Julia A., Palma, Norma, Yelensky, Roman, Lipson, Doron, Miller, Vincent A., Stephens, Philip J., Subbiah, Vivek, Pal, Sumanta K.

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Next-Generation Sequencing Reveals High Concordance of Recurrent Somatic Alterations Between Primary Tumor and Metastases From Patients With Non–Small-Cell Lung Cancer von VIGNOT, Stéphane, FRAMPTON, Garrett M, ANDRE, Fabrice, STEPHENS, Philip J, LAZAR, Vladimir, MILLER, Vincent A, BRAMBILLA, Elisabeth, SORIA, Jean-Charles, YELENSKY, Roman, COMMO, Frédéric, BRAMBILLA, Christian, PALMER, Gary, MORO-SIBILOT, Denis, ROSS, Jeffrey S, CRONIN, Maureen T

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Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti‐HER2 targeted therapies von Ross, Jeffrey S., Gay, Laurie M., Wang, Kai, Ali, Siraj M., Chumsri, Saranya, Elvin, Julia A., Bose, Ron, Vergilio, Jo‐Anne, Suh, James, Yelensky, Roman, Lipson, Doron, Chmielecki, Juliann, Waintraub, Stanley, Leyland‐Jones, Brian, Miller, Vincent A., Stephens, Philip J.

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Comprehensive genomic profiling of extrahepatic cholangiocarcinoma reveals a long tail of therapeutic targets von Lee, Hwajeong, Wang, Kai, Johnson, Adrienne, Jones, David M, Ali, Siraj M, Elvin, Julia A, Yelensky, Roman, Lipson, Doron, Miller, Vincent A, Stephens, Philip J, Javle, Milind, Ross, Jeffrey S

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