Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles von Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.

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Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides von Kapoor, Khyati, Finer-Moore, Janet S., Pedersen, Bjørn P., Caboni, Laura, Waight, Andrew, Hillig, Roman C., Bringmann, Peter, Heisler, Iring, Müller, Thomas, Siebeneicher, Holger, Stroud, Robert M.

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction von Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin

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Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo von Pusch, Stefan, Krausert, Sonja, Fischer, Viktoria, Balss, Jörg, Ott, Martina, Schrimpf, Daniel, Capper, David, Sahm, Felix, Eisel, Jessica, Beck, Ann-Christin, Jugold, Manfred, Eichwald, Viktoria, Kaulfuss, Stefan, Panknin, Olaf, Rehwinkel, Hartmut, Zimmermann, Katja, Hillig, Roman C., Guenther, Judith, Toschi, Luisella, Neuhaus, Roland, Haegebart, Andrea, Hess-Stumpp, Holger, Bauser, Markus, Wick, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Platten, Michael, von Deimling, Andreas

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Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N‑[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration o... von Werner, Stefan, Mesch, Stefanie, Hillig, Roman C, ter Laak, Antonius, Klint, Julie, Neagoe, Ioana, Laux-Biehlmann, Alexis, Dahllöf, Henrik, Bräuer, Nico, Puetter, Vera, Nubbemeyer, Reinhard, Schulz, Simone, Bairlein, Michaela, Zollner, Thomas M, Steinmeyer, Andreas

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Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162 von Moosmayer, Dieter, Hilpmann, André, Hoffmann, Jutta, Schnirch, Lennart, Zimmermann, Katja, Badock, Volker, Furst, Laura, Eaton, John K., Viswanathan, Vasanthi S., Schreiber, Stuart L., Gradl, Stefan, Hillig, Roman C.

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BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe von Günther, Judith, Hillig, Roman C., Zimmermann, Katja, Kaulfuss, Stefan, Lemos, Clara, Nguyen, Duy, Rehwinkel, Hartmut, Habgood, Matthew, Lechner, Christian, Neuhaus, Roland, Ganzer, Ursula, Drewes, Mark, Chai, Jijie, Bouché, Léa

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Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics von Hillisch, Alexander, Gericke, Kersten M, Allerheiligen, Swen, Roehrig, Susanne, Schaefer, Martina, Tersteegen, Adrian, Schulz, Simone, Lienau, Philip, Gnoth, Mark, Puetter, Vera, Hillig, Roman C, Heitmeier, Stefan

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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette

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Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179 von Mowat, Jeffrey, Ehrmann, Alexander H. M, Christian, Sven, Sperl, Carolyn, Menz, Stephan, Günther, Judith, Hillig, Roman C, Bauser, Marcus, Schwede, Wolfgang

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HLA-B27 Subtypes Differentially Associated with Disease Exhibit Subtle Structural Alterations von Hülsmeyer, Martin, Hillig, Roman C., Volz, Armin, Rühl, Melanie, Schröder, Werner, Saenger, Wolfram, Ziegler, Andreas, Uchanska-Ziegler, Barbara

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Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles von Hartung, Ingo V., Pühler, Florian, Neuhaus, Roland, Scholz, Arne, Siemeister, Gerhard, Geisler, Jens, Hillig, Roman C., von Ahsen, Oliver, Hitchcock, Marion

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Thermodynamic and Structural Analysis of Peptide- and Allele-dependent Properties of Two HLA-B27 Subtypes Exhibiting Differential Disease Association von Hillig, Roman C., Hülsmeyer, Martin, Saenger, Wolfram, Welfle, Karin, Misselwitz, Rolf, Welfle, Heinz, Kozerski, Christine, Volz, Armin, Uchanska-Ziegler, Barbara, Ziegler, Andreas

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Back Cover: Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles (ChemMedChem 12/2015) von Hartung, Ingo V., Pühler, Florian, Neuhaus, Roland, Scholz, Arne, Siemeister, Gerhard, Geisler, Jens, Hillig, Roman C., von Ahsen, Oliver, Hitchcock, Marion

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A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors von Schulz, Michèle N., Fanghänel, Jörg, Schäfer, Martina, Badock, Volker, Briem, Hans, Boemer, Ulf, Nguyen, Duy, Husemann, Manfred, Hillig, Roman C.

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Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase MK2 von Hillig, Roman C., Eberspaecher, Uwe, Monteclaro, Felipe, Huber, Martina, Nguyen, Duy, Mengel, Anne, Muller-Tiemann, Beate, Egner, Ursula

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A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte... von Hülsmeyer, Martin, Chames, Patrick, Hillig, Roman C, Stanfield, Robyn L, Held, Gerhard, Coulie, Pierre G, Alings, Claudia, Wille, Gabriele, Saenger, Wolfram, Uchanska-Ziegler, Barbara, Hoogenboom, Hennie R, Ziegler, Andreas

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Targeting RAS oncogenesis with SOS1 inhibitors von Hillig, Roman Christian, Bader, Benjamin

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Surface-mutagenesis strategies to enable structural biology crystallization platforms von Schaefer, Martina, Pütter, Vera, Hilpmann, André, Egner, Ursula, Holton, Simon James, Hillig, Roman Christian

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Fab MOR03268 Triggers Absorption Shift of a Diagnostic Dye via Packaging in a Solvent-shielded Fab Dimer Interface von Hillig, Roman C., Urlinger, Stefanie, Fanghänel, Jörg, Brocks, Bodo, Haenel, Cornelia, Stark, Yvonne, Sülzle, Detlev, Svergun, Dmitri I., Baesler, Siegfried, Malawski, Guido, Moosmayer, Dieter, Menrad, Andreas, Schirner, Michael, Licha, Kai

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