Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors von Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H, Zhang, Ya-Qin, Rohde, Jason M, Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R, Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A, Xia, Menghang, Woo, Juhyung, Mensah, George A, Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B, Biswal, Shyam

Volltext

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth von Montal, Emily D., Dewi, Ruby, Bhalla, Kavita, Ou, Lihui, Hwang, Bor Jang, Ropell, Ashley E., Gordon, Chris, Liu, Wan-Ju, DeBerardinis, Ralph J., Sudderth, Jessica, Twaddel, William, Boros, Laszlo G., Shroyer, Kenneth R., Duraisamy, Sekhar, Drapkin, Ronny, Powers, R. Scott, Rohde, Jason M., Boxer, Matthew B., Wong, Kwok-Kin, Girnun, Geoffrey D.

Volltext

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation von Zong, Guanghui, Hu, Zhijian, O’Keefe, Sarah, Tranter, Dale, Iannotti, Michael J, Baron, Ludivine, Hall, Belinda, Corfield, Katherine, Paatero, Anja O, Henderson, Mark J, Roboti, Peristera, Zhou, Jianhong, Sun, Xianwei, Govindarajan, Mugunthan, Rohde, Jason M, Blanchard, Nicolas, Simmonds, Rachel, Inglese, James, Du, Yuchun, Demangel, Caroline, High, Stephen, Paavilainen, Ville O, Shi, Wei Q

Volltext

Total Synthesis of (±)- and (−)-Actinophyllic Acid von Martin, Connor L, Overman, Larry E, Rohde, Jason M

Volltext

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate von Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Vander Heiden, Matthew G, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

Volltext

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis von Hamanaka, Robert B, Nigdelioglu, Recep, Meliton, Angelo Y, Tian, Yufeng, Witt, Leah J, O'Leary, Erin, Sun, Kaitlyn A, Woods, Parker S, Wu, David, Ansbro, Brandon, Ard, Shawn, Rohde, Jason M, Dulin, Nickolai O, Guzy, Robert D, Mutlu, Gökhan M

Volltext

EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth von Issaq, Sameer H, Mendoza, Arnulfo, Kidner, Ria, Rosales, Tracy I, Duveau, Damien Y, Heske, Christine M, Rohde, Jason M, Boxer, Matthew B, Thomas, Craig J, DeBerardinis, Ralph J, Helman, Lee J

Volltext

Total Synthesis of (±)-Actinophyllic Acid von Martin, Connor L, Overman, Larry E, Rohde, Jason M

Volltext

Discovery and Optimization of 2H‑1λ2‑Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer von Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B

Volltext

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors von Rohde, Jason M., Brimacombe, Kyle R., Liu, Li, Pacold, Michael E., Yasgar, Adam, Cheff, Dorian M., Lee, Tobie D., Rai, Ganesha, Baljinnyam, Bolormaa, Li, Zhuyin, Simeonov, Anton, Hall, Matthew D., Shen, Min, Sabatini, David M., Boxer, Matthew B.

Volltext

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays von Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.

Volltext

Total Synthesis of (+)-Nankakurines A and B and (±)-5-epi-Nankakurine A von Altman, Ryan A, Nilsson, Bradley L, Overman, Larry E, Read de Alaniz, Javier, Rohde, Jason M, Taupin, Veronique

Volltext

Discovery and Optimization of 2 H -1λ 2 -Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer von Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B

Volltext

Enantioselective Total Syntheses of Nankakurines A and B: Confirmation of Structure and Establishment of Absolute Configuration von Nilsson, Bradley L, Overman, Larry E, Read de Alaniz, Javier, Rohde, Jason M

Volltext

Structure activity relationships of human galactokinase inhibitors von Liu, Li, Tang, Manshu, Walsh, Martin J., Brimacombe, Kyle R., Pragani, Rajan, Tanega, Cordelle, Rohde, Jason M., Baker, Heather L., Fernandez, Elizabeth, Blackman, Burchelle, Bougie, James M., Leister, William H., Auld, Douglas S., Shen, Min, Lai, Kent, Boxer, Matthew B.

Volltext

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans von Nakai, Takashi, Perl, Nicholas R, Barden, Timothy C, Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J, Jin, Hong, Kim, Charles, Lee, Thomas W.-H, Long, Kimberly, Moore, Joel, Rohde, Jason M, Sarno, Renee, Segal, Chrissie, Solberg, Erik O, Tobin, Jenny, Zimmer, Daniel P, Currie, Mark G

Volltext

Correction to “An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative... von Parker, Erica N., Cain, Brett N., Hajian, Behnoush, Ulrich, Rebecca J., Geddes, Emily J., Barkho, Sulyman, Lee, Hyang Yeon, Williams, John D., Raynor, Malik, Caridha, Diana, Zaino, Angela, Rohde, Jason M., Zak, Mark, Shekhar, Mrinal, Muñoz, Kristen A., Rzasa, Kara M., Temple, Emily R., Hunt, Diana, Jin, Xiannu, Vuong, Chau, Pannone, Kristina, Kelly, Aya M., Mulligan, Michael P., Lee, Katie K., Lau, Gee W., Hung, Deborah T., Hergenrother, Paul J.

Volltext

Abstract 434: Characterizing the role of serine metabolism in pediatric sarcomas von Issaq, Sameer, Kidner, Ria, Rohde, Jason, Boxer, Matthew, Helman, Lee

Volltext

Synthesis, Aggregation, and Chiroptical Properties of Chiral, Amphiphilic Dendrimers von Laufersweiler, Matthew J, Rohde, Jason M, Chaumette, Jean-Louis, Sarazin, Dominique, Parquette, Jon R

Volltext

Erratum: Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate von Pacold, Michael E, Brimacombe, Kyle R, Chan, Sze Ham, Rohde, Jason M, Lewis, Caroline A, Swier, Lotteke J Y M, Possemato, Richard, Chen, Walter W, Sullivan, Lucas B, Fiske, Brian P, Cho, Steve, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu, Monther-Remaileh, Shaul, Yoav D, Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Wang, Amy Q, Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D, Heiden, Matthew G Vander, Shen, Min, Gray, Nathanael S, Boxer, Matthew B, Sabatini, David M

Volltext