Deuterium medicinal chemistry comes of age von Tung, Roger D

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Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease von PERNI, Robert B, ALMQUIST, Susan J, HEISER, Angela, KALKERI, Gururaj, KOLACZKOWSKI, Elaine, KAI LIN, LUONG, Yu-Ping, GOVINDA RAO, B, TAYLOR, William P, THOMSON, John A, TUNG, Roger D, YUNYI WEI, BYRN, Randal A, KWONG, Ann D, CHAO LIN, CHANDORKAR, Gurudatt, CHATURVEDI, Pravin R, COURTNEY, Lawrence F, DECKER, Caroline J, DINEHART, Kirk, GATES, Cynthia A, HARBESON, Scott L

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Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development von Harbeson, Scott L., Morgan, Adam J., Liu, Julie F., Aslanian, Ara M., Nguyen, Sophia, Bridson, Gary W., Brummel, Christopher L., Wu, Lijun, Tung, Roger D., Pilja, Lana, Braman, Virginia, Uttamsingh, Vinita

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Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir von FURFINE, Eric S, BAKER, Christopher T, HALE, Michael R, REYNOLDS, David J, SALISBURY, Jo A, SEARLE, Andy D, STUDENBERG, Scott D, TODD, Dan, TUNG, Roger D, SPALTENSTEIN, Andrew

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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants von Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A

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Bis(2-oxo-3-oxazolidinyl)phosphinic chloride (1) as a coupling reagent for N-alkyl amino acids von Tung, Roger D, Rich, Daniel H

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Synthesis of D-lysine8-cyclosporine A. Further characterization of BOP-Cl in the 2-7 hexapeptide fragment synthesis von Colucci, William J, Tung, Roger D, Petri, John A, Rich, Daniel H

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Use of N-Fmoc amino acid chlorides and activated 2-(fluorenylmethoxy)-5(4H)-oxazolones in solid-phase peptide synthesis. Efficient syntheses of highly N-alkylated cyclic hexapeptid... von Perlow, Debra S, Erb, Jill M, Gould, Norman P, Tung, Roger D, Freidinger, Roger M, Williams, Peter D, Veber, Daniel F

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BOP-Cl mediated synthesis of the cyclosporine A 8-11 tetrapeptide fragment von Tung, Roger D, Dhaon, Madhup K, Rich, Daniel H

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Design and synthesis of novel conformationally restricted HIV protease inhibitors von Salituro, Francesco G., Baker, Christopher T., Court, John J., Deininger, David D., Kim, Eunice E., Li, Biquin, Novak, Perry M., Rao, Bhisetti G., Pazhanisamy, S., Porter, Margaret D., Schairer, Wayne C., Tung, Roger D.

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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants von Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A

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4-hydroxybutyric acid analogs von Tung, Roger D

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4-HYDROXYBUTYRIC ACID ANALOGS von Tung, Roger D

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Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product von Williams, Peter D, Bock, Mark G, Tung, Roger D, Garsky, Victor M, Perlow, Debra S, Erb, Jill M, Lundell, G. F, Gould, Norman P, Whitter, Willie L

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4-hydroxybutyric acid analogs von Tung, Roger D

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Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization von Perni, Robert B., Pitlik, Janos, Britt, Shawn D., Court, John J., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Levin, Rhonda B., Lin, Chao, Lin, Kai, Moon, Young-Choon, Luong, Yu-Ping, O'Malley, Ethan T., Rao, B.Govinda, Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi

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DEUTERATED IDEBENONE von TUNG, ROGER D

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4-HYDROXYBUTYRIC ACID ANALOGS von Tung, Roger D

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Total synthesis of the unusual cyclosporine amino acid MeBMT von Tung, Roger D, Rich, Daniel H

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Deuterated baricitinib von Tung, Roger D

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