aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity von Rodriguez, Josana, Peglion, Florent, Martin, Jack, Hubatsch, Lars, Reich, Jacob, Hirani, Nisha, Gubieda, Alicia G., Roffey, Jon, Fernandes, Artur Ribeiro, St Johnston, Daniel, Ahringer, Julie, Goehring, Nathan W.

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A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation von Bilsland, Alan E., Liu, Yu, Turnbull, Andrew, Sumpton, David, Stevenson, Katrina, Cairney, Claire J., Boyd, Susan M., Roffey, Jon, Jenkinson, David, Keith, W. Nicol

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Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes von Kjær, Svend, Linch, Mark, Purkiss, Andrew, Kostelecky, Brenda, Knowles, Phillip P, Rosse, Carine, Riou, Philippe, Soudy, Christelle, Kaye, Sarah, Patel, Bhavisha, Soriano, Erika, Murray-Rust, Judith, Barton, Caroline, Dillon, Christian, Roffey, Jon, Parker, Peter J, McDonald, Neil Q

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Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment von Mirza, Amar N, Fry, Micah A, Urman, Nicole M, Atwood, Scott X, Roffey, Jon, Ott, Gregory R, Chen, Bin, Lee, Alex, Brown, Alexander S, Aasi, Sumaira Z, Hollmig, Tyler, Ator, Mark A, Dorsey, Bruce D, Ruggeri, Bruce R, Zificsak, Craig A, Sirota, Marina, Tang, Jean Y, Butte, Atul, Epstein, Ervin, Sarin, Kavita Y, Oro, Anthony E

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Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms von Bilsland, Alan E, Stevenson, Katrina, Liu, Yu, Hoare, Stacey, Cairney, Claire J, Roffey, Jon, Keith, W Nicol

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Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel an... von Lafferty-Whyte, Kyle, Bilsland, Alan, Cairney, Claire J, Hanley, Lorna, Jamieson, Nigel B, Zaffaroni, Nadia, Oien, Karin A, Burns, Sharon, Roffey, Jon, Boyd, Susan M, Keith, W Nicol

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Dynamic telomerase gene suppression via network effects of GSK3 inhibition von Bilsland, Alan E, Hoare, Stacey, Stevenson, Katrina, Plumb, Jane, Gomez-Roman, Natividad, Cairney, Claire, Burns, Sharon, Lafferty-Whyte, Kyle, Roffey, Jon, Hammonds, Tim, Keith, W Nicol

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Abstract 1356: Cell-based screening to identify repressors of wild type and mutated telomerase reverse transcriptase gene promoter activity von Bilsland, Alan, Liu, Yu, Burns, Sharon, Jenkinson, David, Roffey, Jon, Keith, W. Nicol

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Abstract LB-125: The identification of FOXA1/ERα pathway modulators for the treatment of hormone-based therapy resistant breast cancer von roffey, jon, Lejeune, Aurore, Barnard, Michelle, Stock, Julie, Wong, Ai Ching, McKelvie, Jenny, Holmes, Kelly, Carroll, Jason, Myatt, Stephen

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Abstract LB-052: Kinase identification of proximal substrates (KIPS): A novel chemical genetics approach for kinase substrate identification von roffey, jon, Turnbull, Andrew, Dillon, Christian, Boyd, Susan, Riou, Philippe, Linch, Mark, Parker, Peter, Kjaer, Sven, McDonald, Neil

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Abstract LB-B32: Modulation of the Hedgehog signaling pathway in models of basal cell carcinoma by ATP-competitive PKCi inhibitors von Roffey, Jon, Dillon, Christian, Oro, Anthony E., Mirza, Amar N., Sarin, Kavita Y., Aasi, Sumaira Z., Parker, Peter J., Riou, Philippe, Barton, Caroline, Patel, Bhavisha, Turnbull, Andrew, Stanway, Emma, Fowler, Katherine, Ott, Gregory, Ator, Mark

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Addressing the Right Targets in Oncology: Challenges and Alternative Approaches von Stock, Julie K., Jones, Neil P., Hammonds, Tim, Roffey, Jon, Dillon, Christian

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Cancer cell senescence: a new frontier in drug development von Cairney, Claire J., Bilsland, Alan E., Evans, T.R. Jeffry, Roffey, Jon, Bennett, Dorothy C., Narita, Masashi, Torrance, Christopher J., Keith, W. Nicol

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Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids von Linch, Mark, Sanz-Garcia, Marta, Rosse, Carine, Riou, Philippe, Peel, Nick, Madsen, Chris D, Sahai, Erik, Downward, Julian, Khwaja, Asim, Dillon, Christian, Roffey, Jon, Cameron, Angus J M, Parker, Peter J

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Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms: e100344... von Bilsland, Alan E, Stevenson, Katrina, Liu, Yu, Hoare, Stacey, Cairney, Claire J, Roffey, Jon, Keith, W Nicol

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Protein kinase C intervention—the state of play von Roffey, Jon, Rosse, Carine, Linch, Mark, Hibbert, Andrew, McDonald, Neil Q, Parker, Peter J

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Abstract A280: Small molecule inhibition of atypical protein kinase C iota reveals a functional basis for oncogenesis von Linch, Mark, Sanz-Garcia, Marta, Kjaer, Svend, Soriano, Erika, Riou, Philippe, Knowles, Philip, Dillon, Christian, Roffey, Jon, McDonald, Neil, Parker, Peter

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Abstract C126: Molecular profiling of the HES transcription factor-TLE co-repressor protein-protein interaction site von Roffey, Jon R., Hammonds, Tim, Raynham, Tony, Dillon, Christian, Hyde, Cali, Pearl, Laurence, Ish-Horowicz, David

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Abstract LB-99: Identification and characterization of small molecule thieno[3,2-d]pyrimidine inhibitors of Protein Kinase C iota (PKCι) von Soudy, Christelle, Stanway, Emma, Patel, Bhavisha, Barton, Caroline, Barnard, Michelle, Pang, Leon, Owen, Paul, Turnbull, Andrew, Ruggeri, Bruce A., Dorsey, Bruce D., Ator, Mark A., Ott, Greg R., Linch, Mark, Riou, Philippe, Parker, Peter J., Kjaer, Sven, Dillon, Christian, McDonald, Neil Q., Roffey, Jon

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INHIBITORS OF MLH1 AND/OR PMS2 FOR CANCER TREATMENT von Winship, Paul, Blagg, Julian, Roffey, Jon, Drysdale, Martin, Clark, David

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