Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist von DOBRZANSKI, Pawel, HUNTER, Kathryn, JONES-BOLIN, Susan, HONG CHANG, ROBINSON, Candy, PRITCHARD, Sonya, HUGH ZHAO, RUGGERI, Bruce

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Structure-guided identification of novel VEGFR-2 kinase inhibitors via solution phase parallel synthesis von Tripathy, Rabindranath, Reiboldt, Alyssa, Messina, Patricia A., Iqbal, Mohamed, Singh, Jasbir, Bacon, Edward R., Angeles, Thelma S., Yang, Shi X., Albom, Mark S., Robinson, Candy, Chang, Hong, Ruggeri, Bruce A., Mallamo, John P.

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Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders von Hexner, Elizabeth O., Serdikoff, Cynthia, Jan, Mahfuza, Swider, Cezary R., Robinson, Candy, Yang, Shi, Angeles, Thelma, Emerson, Stephen G., Carroll, Martin, Ruggeri, Bruce, Dobrzanski, Pawel

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The Chemopreventive Agent Oltipraz Possesses Potent Antiangiogenic Activity in Vitro, ex Vivo, and in Vivo and Inhibits Tumor Xenograft Growth von RUGGERI, Bruce A, ROBINSON, Candy, ANGELES, Thelma, WILKINSON, John IV, CLAPPER, Margie L

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Involvement of endothelial PECAM-1/CD31 in angiogenesis von DeLisser, HM, Christofidou-Solomidou, M, Strieter, RM, Burdick, MD, Robinson, CS, Wexler, RS, Kerr, JS, Garlanda, C, Merwin, JR, Madri, JA, Albelda, SM

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CEP-7055: A novel, orally active pan inhibitor of vascular endothelial growth Factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclin... von RUGGERI, Bruce, SINGH, Jasbir, AIMONE, Lisa, KLEIN-SZANTO, Andres, HERBERT, Jean-Marc, BONO, Francoise, SCHAEFFER, Paul, CASELLAS, Pierre, BOURIE, Bernard, PILI, Roberto, ISAACS, John, ATOR, Mark, GINGRICH, Diane, HUDKINS, Robert, VAUGHT, Jeffry, MALLAMO, John, DIONNE, Craig, ANGELES, Thelma, ALBOM, Mark, HONG CHANG, ROBINSON, Candy, HUNTER, Kathryn, DOBRZANSKI, Pawel, JONES-BOLIN, Susan

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Acyl CoA:Cholesterol Acyltransferase (ACAT) Inhibitors: Synthesis and Structure-Activity Relationship Studies of a New Series of Trisubstituted Imidazoles von Higley, C. Anne, Wilde, Richard G, Maduskuie, Thomas P, Johnson, Alexander L, Pennev, Pennio, Billheimer, Jeffrey T, Robinson, Candy S, Gillies, Peter J, Wexler, Ruth R

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A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors:  Structure−Activity Relationships for a Series of 9-Alkoxymethyl-12-(3-hydroxypropyl)i... von Gingrich, Diane E, Reddy, Dandu R, Iqbal, Mohamed A, Singh, Jasbir, Aimone, Lisa D, Angeles, Thelma S, Albom, Mark, Yang, Shi, Ator, Mark A, Meyer, Sheryl L, Robinson, Candy, Ruggeri, Bruce A, Dionne, Craig A, Vaught, Jeffry L, Mallamo, John P, Hudkins, Robert L

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THE CHARACTERIZATION OF POTENT NOVEL WARFARIN ANALOGS von Kerr, Janet S, Li, Hui-Yin, Wexler, Roseanne S, Robinson, Andrea J, Robinson, Candy S, Boswell, George A, Krauthauser, Candice, Harlow, Patricia P

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TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4- a]pyrrolo[3,4- c]carbazole analogs von Underiner, Ted L., Ruggeri, Bruce, Aimone, Lisa, Albom, Mark, Angeles, Thelma, Chang, Hong, Hudkins, Robert L., Hunter, Kathryn, Josef, Kurt, Robinson, Candy, Weinberg, Linda, Yang, Shi, Zulli, Allison

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Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4- a]pyrrolo[3,4- c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors von Becknell, Nadine C., Zulli, Allison L., Angeles, Thelma S., Yang, Shi, Albom, Mark S., Aimone, Lisa D., Robinson, Candy, Chang, Hong, Hudkins, Robert L.

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Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders. Com... von SKODA, Radek C, HEXNER, Elizabeth O, RUGGERI, Bruce, DOBRZANSKI, Pawel, SERDIKOFF, Cynthia, JAN, Mahfuza, SWIDER, Cezary R, ROBINSON, Candy, SHI YANG, ANGELES, Thelma, EMERSON, Stephen G, CARROLL, Martin

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Design and synthesis of dihydroindazolo[5,4- a]pyrrolo[3,4- c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases von Dandu, Reddeppareddy, Zulli, Allison L., Bacon, Edward R., Underiner, Ted, Robinson, Candy, Chang, Hong, Miknyoczki, Sheila, Grobelny, Jennifer, Ruggeri, Bruce A., Yang, Shi, Albom, Mark S., Angeles, Thelma S., Aimone, Lisa D., Hudkins, Robert L.

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CEP-701 Is a JAK2 Inhibitor Which Attenuates JAK2/STAT5 Signaling Pathway and the Proliferation of Primary Cells from Patients with Myeloproliferative Disorders von Dobrzanski, Pawel, Hexner, Elizabeth, Serdikoff, Cynthia, Jan, Mahfuza, Swider, Cezary, Robinson, Candy, Yang, Shi, Angeles, Thelma, Emerson, Stephen G., Carroll, Martin, Ruggeri, Bruce

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Regulation of ACAT activity by a cholesterol substrate pool during the progression and regression phases of atherosclerosis: implications for drug discovery von Gillies, Peter J., Robinson, Candy S., Rathgeb, Kathy A.

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Regulation of acyl-CoA:Cholesterol acyltransferase activity in normal and atherosclerotic rabbit aortas: Role of a cholesterol substrate pool von Gillies, Peter J., Rathgeb, Kathy A., Perri, Marie A., Robinson, Candy S.

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Decreased plasma membrane fluidity in the development of atherosclerosis in cholesterol-fed rabbits von Gillies, Peter, Robinson, Candy

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Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihyper... von Li, Hui-Yin, DeLucca, Indawati, Boswell, George A., Billheimer, Jeffrey T., Drummond, Spencer, Gillies, Peter J., Robinson, Candy

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Whole Blood and Plasma Concentrations of 4-Hydroxy-2-nonenal in Watanabe Heritable Hyperlipidemic Versus New Zealand White Rabbits von Kinter, M., Robinson, C.S., Grimminger, L.C., Gillies, P.J., Shimshick, E.J., Ayers, C.

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Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl coa: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents von Boswell, George A, Li, Hui-Yin, Delucca, Indawati, Billheimer, Jeffrey T., Drummond, Spencer, Gillies, Peter J., Robinson, Candy

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