DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria von Karakasilioti, Ismene, Kamileri, Irene, Chatzinikolaou, Georgia, Kosteas, Theodoros, Vergadi, Eleni, Robinson, Andria Rasile, Tsamardinos, Iannis, Rozgaja, Tania A., Siakouli, Sandra, Tsatsanis, Christos, Niedernhofer, Laura J., Garinis, George A.

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NF-κB inhibition delays DNA damage-induced senescence and aging in mice von Tilstra, Jeremy S, Robinson, Andria R, Wang, Jin, Gregg, Siobhán Q, Clauson, Cheryl L, Reay, Daniel P, Nasto, Luigi A, St Croix, Claudette M, Usas, Arvydas, Vo, Nam, Huard, Johnny, Clemens, Paula R, Stolz, Donna B, Guttridge, Denis C, Watkins, Simon C, Garinis, George A, Wang, Yinsheng, Niedernhofer, Laura J, Robbins, Paul D

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Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration von Nasto, Luigi A., Robinson, Andria R., Ngo, Kevin, Clauson, Cheryl L., Dong, Qing, St. Croix, Claudette, Sowa, Gwendolyn, Pola, Enrico, Robbins, Paul D., Kang, James, Niedernhofer, Laura J., Wipf, Peter, Vo, Nam V.

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Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model von Lavasani, Mitra, Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny

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A mouse model of accelerated liver aging caused by a defect in DNA repair von Gregg, Siobhán Q., Gutiérrez, Verónica, Rasile Robinson, Andria, Woodell, Tyler, Nakao, Atsunori, Ross, Mark A., Michalopoulos, George K., Rigatti, Lora, Rothermel, Carrie E., Kamileri, Irene, Garinis, George A., Beer Stolz, Donna, Niedernhofer, Laura J.

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DNA damage drives accelerated bone aging via an NF‐κB–dependent mechanism von Chen, Qian, Liu, Kai, Robinson, Andria R, Clauson, Cheryl L, Blair, Harry C, Robbins, Paul D, Niedernhofer, Laura J, Ouyang, Hongjiao

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ISSLS Prize Winner: Inhibition of NF-κB Activity Ameliorates Age-Associated Disc Degeneration in a Mouse Model of Accelerated Aging von NASTO, Luigi A, SEO, Hyoung-Yeon, NIEDERNHOFER, Laura J, KANG, James D, ROBBINS, Paul D, VO, Nam V, ROBINSON, Andria R, TILSTRA, Jeremy S, CLAUSON, Cheryl L, SOWA, Gwendolyn A, NGO, Kevin, QING DONG, POLA, Enrico, LEE, Joon Y

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Investigating the role of DNA damage in tobacco smoking-induced spine degeneration von Nasto, Luigi A., MD, Ngo, Kevin, BS, Leme, Adriana S., PhD, Robinson, Andria R., PhD, Dong, Qing, MS, Roughley, Peter, PhD, Usas, Arvydas, PhD, Sowa, Gwendolyn A., MD, PhD, Pola, Enrico, MD, Kang, James, MD, Niedernhofer, Laura J., MD, PhD, Shapiro, Steven, MD, Vo, Nam V., PhD

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis von Robinson, Andria Rasile, Appeldoorn, Esther, Hoeijmakers, Jan H. J, Theil, Arjan F, Raams, Anja, Odijk, Hanny, Kleijer, Wim J, Meinecke, Peter, van Leeuwen, Wibeke, Lalai, Astrid S, Ahmad, Anwaar, Niedernhofer, Laura J, Vijg, Jan, Jaspers, Nicolaas G. J, Garinis, George A, Vermeulen, Wim, van der Horst, Gijsbertus T. J, Oostendorp, Roos

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Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging von Gurkar, Aditi U., Robinson, Andria R., Cui, Yuxiang, Li, Xuesen, Allani, Shailaja K., Webster, Amanda, Muravia, Mariya, Fallahi, Mohammad, Weissbach, Herbert, Robbins, Paul D., Wang, Yinsheng, Kelley, Eric E., Croix, Claudette M. St, Niedernhofer, Laura J., Gill, Matthew S.

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Delayed and accelerated aging share common longevity assurance mechanisms von Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J, Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M, van Steeg, Harry, Niedernhofer, Laura J, van Ijcken, Wilfred, Bartke, Andrzej, Spindler, Stephen R, Hoeijmakers, Jan H J, van der Horst, Gijsbertus T J, Garinis, George A

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ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation von Czerwińska, Jolanta, Nowak, Małgorzata, Wojtczak, Patrycja, Dziuban-Lech, Dorota, Cieśla, Jarosław M., Kołata, Daria, Gajewska, Beata, Barańczyk-Kuźma, Anna, Robinson, Andria R., Shane, Hillary L., Gregg, Siobhán Q., Rigatti, Lora H., Yousefzadeh, Matthew J., Gurkar, Aditi U., McGowan, Sara J., Kosicki, Konrad, Bednarek, Małgorzata, Zarakowska, Ewelina, Gackowski, Daniel, Oliński, Ryszard, Speina, Elżbieta, Niedernhofer, Laura J., Tudek, Barbara

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Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model von Lavasani, Mitra, Robinson, Andria R., Lu, Aiping, Song, Minjung, Feduska, Joseph M., Ahani, Bahar, Tilstra, Jeremy S., Feldman, Chelsea H., Robbins, Paul D., Niedernhofer, Laura J., Huard, Johnny

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Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts von Steinman, Richard A, Robinson, Andria Rasile, Feghali-Bostwick, Carol A

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ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair von Ahmad, Anwaar, Robinson, Andria Rasile, Duensing, Anette, van Drunen, Ellen, Beverloo, H. Berna, Weisberg, David B., Hasty, Paul, Hoeijmakers, Jan H. J., Niedernhofer, Laura J.

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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging von Robinson, Andria R., Yousefzadeh, Matthew J., Rozgaja, Tania A., Wang, Jin, Li, Xuesen, Tilstra, Jeremy S., Feldman, Chelsea H., Gregg, Siobhán Q., Johnson, Caroline H., Skoda, Erin M., Frantz, Marie-Céline, Bell-Temin, Harris, Pope-Varsalona, Hannah, Gurkar, Aditi U., Nasto, Luigi A., Robinson, Renã A.S., Fuhrmann-Stroissnigg, Heike, Czerwinska, Jolanta, McGowan, Sara J., Cantu-Medellin, Nadiezhda, Harris, Jamie B., Maniar, Salony, Ross, Mark A., Trussoni, Christy E., LaRusso, Nicholas F., Cifuentes-Pagano, Eugenia, Pagano, Patrick J., Tudek, Barbara, Vo, Nam V., Rigatti, Lora H., Opresko, Patricia L., Stolz, Donna B., Watkins, Simon C., Burd, Christin E., Croix, Claudette M. St, Siuzdak, Gary, Yates, Nathan A., Robbins, Paul D., Wang, Yinsheng, Wipf, Peter, Kelley, Eric E., Niedernhofer, Laura J.

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Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs von Nasto, Luigi A., Wang, Dong, Robinson, Andria R., Clauson, Cheryl L., Ngo, Kevin, Dong, Qing, Roughley, Peter, Epperly, Michael, Huq, Saiful M., Pola, Enrico, Sowa, Gwendolyn, Robbins, Paul D., Kang, James, Niedernhofer, Laura J., Vo, Nam V.

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Age‐related dystrophic changes in corneal endothelium from DNA repair–deficient mice von Roh, Danny S., Du, Yiqin, Gabriele, Michelle L., Robinson, Andria R., Niedernhofer, Laura J., Funderburgh, James L.

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Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice von Smith, Scott C, Robinson, Andria R, Niedernhofer, Laura J, Hetman, Michal

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Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model von Matoka, Derek J., Yao, Veronica, Harya, Diana S., Gregg, Jennifer L., Robinson, Andria R., Niedernhofer, Laura J., Parwani, Anil V., Maier, Christoph, Bacich, Dean J.

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