Enzymes as a special class of therapeutic target: clinical drugs and modes of action von Robertson, James G.

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Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes von Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G

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Mechanistic Basis of Enzyme-Targeted Drugs von Robertson, James G

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OPF Techniques for Real-Time Active Management of Distribution Networks von Robertson, James G., Harrison, Gareth P., Wallace, A. Robin

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Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors von Zhao, Guohua, Kwon, Chet, Wang, Aiying, Robertson, James G., Marcinkeviciene, Jovita, Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.

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Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes von Meng, Wei, Ellsworth, Bruce A, Nirschl, Alexandra A, McCann, Peggy J, Patel, Manorama, Girotra, Ravindar N, Wu, Gang, Sher, Philip M, Morrison, Eamonn P, Biller, Scott A, Zahler, Robert, Deshpande, Prashant P, Pullockaran, Annie, Hagan, Deborah L, Morgan, Nathan, Taylor, Joseph R, Obermeier, Mary T, Humphreys, William G, Khanna, Ashish, Discenza, Lorell, Robertson, James G, Wang, Aiying, Han, Songping, Wetterau, John R, Janovitz, Evan B, Flint, Oliver P, Whaley, Jean M, Washburn, William N

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Aglycone exploration of C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2 von Ellsworth, Bruce A., Meng, Wei, Patel, Manorama, Girotra, Ravindar N., Wu, Gang, Sher, Philip M., Hagan, Deborah L., Obermeier, Mary T., Humphreys, William G., Robertson, James G., Wang, Aiying, Han, Songping, Waldron, Thomas L., Morgan, Nathan N., Whaley, Jean M., Washburn, William N.

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Synthesis of Novel Potent Dipeptidyl Peptidase IV Inhibitors with Enhanced Chemical Stability:  Interplay between the N-Terminal Amino Acid Alkyl Side Chain and the Cyclopropyl Gro... von Magnin, David R, Robl, Jeffrey A, Sulsky, Richard B, Augeri, David J, Huang, Yanting, Simpkins, Ligaya M, Taunk, Prakash C, Betebenner, David A, Robertson, James G, Abboa-Offei, Benoni E, Wang, Aiying, Cap, Michael, Xin, Li, Tao, Li, Sitkoff, Doree F, Malley, Mary F, Gougoutas, Jack Z, Khanna, Ashish, Huang, Qi, Han, Song-Ping, Parker, Rex A, Hamann, Lawrence G

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4-Thiazolidinones: Novel inhibitors of the bacterial enzyme MurB von ANDRES, C. J, BRONSON, A. J. J, STOCK, D, YAXIONG SUN, WALSH, A. W, D'ANDREA, A. S. V, DESHPANDE, A. M. S, FALK, P. J, GRANT-YOUNG, K. A, HARTE, W. E, HO, H.-T, MISCO, P. F, ROBERTSON, J. G

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Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors von Simpkins, Ligaya M., Bolton, Scott, Pi, Zulan, Sutton, James C., Kwon, Chet, Zhao, Guohua, Magnin, David R., Augeri, David J., Gungor, Timur, Rotella, David P., Sun, Zhong, Liu, Yajun, Slusarchyk, William S., Marcinkeviciene, Jovita, Robertson, James G., Wang, Aiying, Robl, Jeffrey A., Atwal, Karnail S., Zahler, Robert L., Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.

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Mechanistic Basis of Enzyme-Targeted Drugs von Robertson, James G

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Characterization of NADP + binding to perdeuterated MurB: backbone atom NMR assignments and chemical-shift changes von Constantine, Keith L, Mueller, Luciano, Goldfarb, Valentina, Wittekind, Michael, Metzler, William J, Yanchunas, Joseph, Robertson, James G, Malley, Mary F, Friedrichs, Mark S, Farmer, Bennett T

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Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors von Zhao, Guohua, Taunk, Prakash C., Magnin, David R., Simpkins, Ligaya M., Robl, Jeffrey A., Wang, Aiying, Robertson, James G., Marcinkeviciene, Jovita, Sitkoff, Doree F., Parker, Rex A., Kirby, Mark S., Hamann, Lawrence G.

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Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1 von Magnin, David R., Taunk, Prakash C., Robertson, James G., Wang, Aiying, Marcinkeviciene, Jovita, Kirby, Mark S., Hamann, Lawrence G.

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Application of robotics to steady state enzyme kinetics: analysis of tight-binding inhibitors of dipeptidyl peptidase IV von Wang, Aiying, Huang, Yanting, Taunk, Prakash, Magnin, David R, Ghosh, Krishnendu, Robertson, James G

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Determination of Subunit Dissociation Constants in Native and Inactivated CTP Synthetase by Sedimentation Equilibrium von Robertson, James G

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Localizing the NADP+ binding site on the MurB enzyme by NMR von Farmer, Bennett T., Constantine, Keith L., Goldfarb, Valentina, Friedrichs, Mark S., Wittekind, Michael, Yanchunas, Joseph, Robertson, James G., Mueller, Luciano

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Steady-State Kinetic Mechanism of Escherichia coli UDP-N-Acetylenolpyruvylglucosamine Reductase von Dhalla, Adil M, Yanchunas, Joseph, Ho, Hsu-Tso, Falk, Paul, Villafranca, Joseph J, Robertson, James G

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Structural Studies of Escherichia coli UDP-N-Acetylmuramate:l-Alanine Ligase von Jin, Haiyong, Emanuele, John J, Fairman, Robert, Robertson, James G, Hail, Mark E, Ho, Hsu-Tso, Falk, Paul J, Villafranca, Joseph J

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Complete Assignment of Disulfide Bonds in Bovine Dopamine .beta.-Hydroxylase von Robertson, James G, Adams, Gregory W, Medzihradszky, Katalin F, Burlingame, Alma L, Villafranca, Joseph J

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