A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors von Lanning, Bryan R, Whitby, Landon R, Dix, Melissa M, Douhan, John, Gilbert, Adam M, Hett, Erik C, Johnson, Theodore O, Joslyn, Chris, Kath, John C, Niessen, Sherry, Roberts, Lee R, Schnute, Mark E, Wang, Chu, Hulce, Jonathan J, Wei, Baoxian, Whiteley, Laurence O, Hayward, Matthew M, Cravatt, Benjamin F

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Detection of cell–cell interactions via photocatalytic cell tagging von Oslund, Rob C., Reyes-Robles, Tamara, White, Cory H., Tomlinson, Jake H., Crotty, Kelly A., Bowman, Edward P., Chang, Dan, Peterson, Vanessa M., Li, Lixia, Frutos, Silvia, Vila-Perelló, Miquel, Vlerick, David, Cromie, Karen, Perlman, David H., Ingale, Sampat, Hara, Samantha D. O’, Roberts, Lee R., Piizzi, Grazia, Hett, Erik C., Hazuda, Daria J., Fadeyi, Olugbeminiyi O.

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Lead discovery and optimization strategies for peptide macrocycles von Bhat, Abhijit, Roberts, Lee R., Dwyer, John J.

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Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens von Ervin, Samantha M., Li, Hao, Lim, Lauren, Roberts, Lee R., Liang, Xue, Mani, Sridhar, Redinbo, Matthew R.

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Click-enabled heterotrifunctional template for sequential bioconjugations von Beal, David M, Albrow, Victoria E, Burslem, George, Hitchen, Louisa, Fernandes, Carla, Lapthorn, Cris, Roberts, Lee R, Selby, Matthew D, Jones, Lyn H

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A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays von Kasper, Stephen H, Otten, Stephanie, Squadroni, Brian, Orr-Terry, Cionna, Kuang, Yi, Mussallem, Lily, Ge, Lan, Yan, Lin, Kannan, Srinivasaraghavan, Verma, Chandra S, Brown, Christopher J, Johannes, Charles W, Lane, David P, Chandramohan, Arun, Partridge, Anthony W, Roberts, Lee R, Josien, Hubert, Therien, Alex G, Hett, Erik C, Howell, Bonnie J, Peier, Andrea, Ai, Xi, Cassaday, Jason

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Design and Structure of Stapled Peptides Binding to Estrogen Receptors von Phillips, Chris, Roberts, Lee R, Schade, Markus, Bazin, Richard, Bent, Andrew, Davies, Nichola L, Moore, Rob, Pannifer, Andrew D, Pickford, Andrew R, Prior, Stephen H, Read, Christopher M, Scott, Andrew, Brown, David G, Xu, Bin, Irving, Stephen L

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Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling von Jariwala, Parth B, Pellock, Samuel J, Goldfarb, Dennis, Cloer, Erica W, Artola, Marta, Simpson, Joshua B, Bhatt, Aadra P, Walton, William G, Roberts, Lee R, Major, Michael B, Davies, Gideon J, Overkleeft, Herman S, Redinbo, Matthew R

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An electroaffinity labelling platform for chemoproteomic-based target identification von Kawamata, Yu, Ryu, Keun Ah, Hermann, Gary N., Sandahl, Alexander, Vantourout, Julien C., Olow, Aleksandra K., Adams, La-Tonya A., Rivera-Chao, Eva, Roberts, Lee R., Gnaim, Samer, Nassir, Molhm, Oslund, Rob C., Fadeyi, Olugbeminiyi O., Baran, Phil S.

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Acidic triazoles as soluble guanylate cyclase stimulators von Roberts, Lee R., Bradley, Paul A., Bunnage, Mark E., England, Katherine S., Fairman, David, Fobian, Yvette M., Fox, David N.A., Gymer, Geoff E., Heasley, Steven E., Molette, Jerome, Smith, Graham L., Schmidt, Michelle A., Tones, Michael A., Dack, Kevin N.

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Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability von Johnson, Patrick S., Ryckmans, Thomas, Bryans, Justin, Beal, Dave M., Dack, Kevin N., Feeder, Neil, Harrison, Anthony, Lewis, Mark, Mason, Helen J., Mills, James, Newman, Julie, Pasquinet, Christelle, Rawson, Dave J., Roberts, Lee R., Russell, Rachel, Spark, Deborah, Stobie, Alan, Underwood, Toby J., Ward, Robin, Wheeler, Simon

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Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics von Simpson, Joshua B., Walker, Morgan E., Sekela, Joshua J., Ivey, Samantha M., Jariwala, Parth B., Storch, Cameron M., Kowalewski, Mark E., Graboski, Amanda L., Lietzan, Adam D., Walton, William G., Davis, Kacey A., Cloer, Erica W., Borlandelli, Valentina, Hsiao, Yun-Chung, Roberts, Lee R., Perlman, David H., Liang, Xue, Overkleeft, Hermen S., Bhatt, Aadra P., Lu, Kun, Redinbo, Matthew R.

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Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium von Porter, James D, Watson, Jennifer, Roberts, Lee R, Gill, Simren K, Groves, Helen, Dhariwal, Jaideep, Almond, Mark H, Wong, Ernie, Walton, Ross P, Jones, Lyn H, Tregoning, John, Kilty, Iain, Johnston, Sebastian L, Edwards, Michael R

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Design of a Multiuse Photoreactor To Enable Visible‐Light Photocatalytic Chemical Transformations and Labeling in Live Cells von Bissonnette, Noah B., Ryu, Keun Ah, Reyes‐Robles, Tamara, Wilhelm, Sharon, Tomlinson, Jake H., Crotty, Kelly A., Hett, Erik C., Roberts, Lee R., Hazuda, Daria J., Jared Willis, M., Oslund, Rob C., Fadeyi, Olugbeminiyi O.

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Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5‑d]azepines as Potent 5‑Hydroxytryptamine 2C (5-HT2C) Receptor Agonists with Exquisite Functional Selectivi... von Storer, R. Ian, Brennan, Paul E, Brown, Alan D, Bungay, Peter J, Conlon, Kelly M, Corbett, Matthew S, DePianta, Robert P, Fish, Paul V, Heifetz, Alexander, Ho, Danny K. H, Jessiman, Alan S, McMurray, Gordon, de Oliveira, Cesar Augusto F, Roberts, Lee R, Root, James A, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Skerten, Melanie, Westbrook, Dominique, Wheeler, Simon, Whitlock, Gavin A, Wright, John

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Quantitative measurement of intracellular HDAC1/2 drug occupancy using a trans -cyclooctene largazole thiol probe von Xu, Hua, Roberts, Lee R, Chou, Song, Pierce, Betsy, Narayanan, Arjun, Jones, Lyn H

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7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization von Fish, Paul V, Brown, Alan D, Evrard, Edel, Roberts, Lee R

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Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists von ROBERTS, Lee R, BRYANS, Justin, CONLON, Kelly, MCMURRAY, Gordon, STOBIE, Alan, WHITLOCK, Gavin A

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Kappa agonist CovX-Bodies von Roberts, Lee R., Brady, Kevin, Brown, Amy, Davey, Doreen, Feng, Lijin, Huang, Hanhua, Liu, Dingguo, Malet, Laia, McMurray, Gordon, Phelan, Anne, Saunders, Ken, Bhat, Abhijit

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The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2 von Wakenhut, Florian, Tran, Thien Duc, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Stonehouse, David, Cheung, Kathy, Wybrow, Robert, Daverio, Felice, Crook, Samuel, Statham, Keith, Leese, David, Stead, Darren, Adam, Fiona, Hay, Duncan, Roberts, Lee R., Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C., Goetz, Gilles H., Che, Ye, Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob, Pryde, David C.

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