Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme‑1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation von Mandal, Mihirbaran, Zhu, Zhaoning, Cumming, Jared N, Liu, Xiaoxiang, Strickland, Corey, Mazzola, Robert D, Caldwell, John P, Leach, Prescott, Grzelak, Michael, Hyde, Lynn, Zhang, Qi, Terracina, Giuseppe, Zhang, Lili, Chen, Xia, Kuvelkar, Reshma, Kennedy, Matthew E, Favreau, Leonard, Cox, Kathleen, Orth, Peter, Buevich, Alexei, Voigt, Johannes, Wang, Hongwu, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Parker, Eric M, Stamford, Andrew W

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Generation of Leads for γ‑Secretase Modulation von Mandal, Mihirbaran, Buevich, Alexei, Caldwell, John P, Hyde, Lynn, Huang, Xianhai, Liu, Xiaoxiang, McKittrick, Brian, Mazzola, Robert D, Pissarnitski, Dmitri, Palani, Anandan, Zhang, Lili, Parker, Eric, Xiao, Li, Rindgen, Diane, Zhu, Zhaoning

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Stereoselective Nazarov Cyclizations of Bridged Bicyclic Dienones von Mazzola, Robert D, White, Timothy D, Vollmer-Snarr, Heidi R, West, F. G

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors. Part II: Optimization of the S3′ pocket von Mazzola, Robert D., Zhu, Zhaoning, Sinning, Lisa, McKittrick, Brian, Lavey, Brian, Spitler, James, Kozlowski, Joseph, Neng-Yang, Shih, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Sun, Jing, Lundell, Daniel, Niu, Xiaoda

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Unexpected Participation of an Unconjugated Olefin during Nazarov Cyclization of Bridged Bicyclic Dienones von Giese, Sören, Mazzola Jr, Robert D., Amann, Clare M., Arif, Atta M., West, F. G.

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Structure-Based Design of an Iminoheterocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates von Mandal, Mihirbaran, Wu, Yusheng, Misiaszek, Jeffrey, Li, Guoqing, Buevich, Alexei, Caldwell, John P, Liu, Xiaoxiang, Mazzola, Robert D, Orth, Peter, Strickland, Corey, Voigt, Johannes, Wang, Hongwu, Zhu, Zhaoning, Chen, Xia, Grzelak, Michael, Hyde, Lynn A, Kuvelkar, Reshma, Leach, Prescott T, Terracina, Giuseppe, Zhang, Lili, Zhang, Qi, Michener, Maria S, Smith, Brad, Cox, Kathleen, Grotz, Diane, Favreau, Leonard, Mitra, Kaushik, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Kennedy, Matthew E, Parker, Eric M, Cumming, Jared N, Stamford, Andrew W

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Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety von Mandal, Mihirbaran, Mitra, Kaushik, Grotz, Diane, Lin, Xinjie, Palamanda, Jairam, Kumari, Pramila, Buevich, Alexei, Caldwell, John P, Chen, Xia, Cox, Kathleen, Favreau, Leonard, Hyde, Lynn, Kennedy, Matthew E, Kuvelkar, Reshma, Liu, Xiaoxiang, Mazzola, Robert D, Parker, Eric, Rindgen, Diane, Sherer, Edward, Wang, Hongwu, Zhu, Zhaoning, Stamford, Andrew W, Cumming, Jared N

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Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists von Qiang, Li, Sasikumar, T K, Burnett, Duane A, Su, Jing, Tang, Haiqun, Ye, Yuanzan, Mazzola, Jr, Robert D, Zhu, Zhaoning, McKittrick, Brian A, Greenlee, William J, Fawzi, Ahmad, Smith, Michelle, Zhang, Hongtao, Lachowicz, Jean E

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Discovery of potent iminoheterocycle BACE1 inhibitors von Caldwell, John P., Mazzola, Robert D., Durkin, James, Chen, Joseph, Chen, Xia, Favreau, Leonard, Kennedy, Matthew, Kuvelkar, Reshma, Lee, Julie, McHugh, Nansie, McKittrick, Brian, Orth, Peter, Stamford, Andrew, Strickland, Corey, Voigt, Johannes, Wang, Liyang, Zhang, Lili, Zhang, Qi, Zhu, Zhaoning

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Iminoheterocycles as γ-secretase modulators von Caldwell, John P., Bennett, Chad E., McCracken, Troy M., Mazzola, Robert D., Bara, Thomas, Buevich, Alexei, Burnett, Duane A., Chu, Inhou, Cohen-Williams, Mary, Josein, Hubert, Hyde, Lynn, Lee, Julie, McKittrick, Brian, Song, Lixin, Terracina, Giuseppe, Voigt, Johannes, Zhang, Lili, Zhu, Zhaoning

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Unexpected Participation of an Unconjugated Olefin during Nazarov Cyclization of Bridged Bicyclic Dienones von Giese, Sören, Mazzola Jr, Robert D., Amann, Clare M., Arif, Atta M., West, F. G.

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Discovery of new SCH 39166 analogs as potent and selective dopamine D 1 receptor antagonists von Qiang, Li, Sasikumar, T.K., Burnett, Duane A., Su, Jing, Tang, Haiqun, Ye, Yuanzan, Mazzola, Robert D., Zhu, Zhaoning, McKittrick, Brian A., Greenlee, William J., Fawzi, Ahmad, Smith, Michelle, Zhang, Hongtao, Lachowicz, Jean E.

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Discovery of new SCH 39166 analogs as potent and selective dopamine D sub(1) receptor antagonists von Qiang, Li, Sasikumar, T K, Burnett, Duane A, Su, Jing, Tang, Haiqun, Ye, Yuanzan, Mazzola, Robert D, Zhu, Zhaoning, McKittrick, Brian A, Greenlee, William J, Fawzi, Ahmad, Smith, Michelle, Zhang, Hongtao, Lachowicz, Jean E

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Iminoheterocycles as g-secretase modulators von Caldwell, John P, Bennett, Chad E, McCracken, Troy M, Mazzola, Robert D, Bara, Thomas, Buevich, Alexei, Burnett, Duane A, Chu, Inhou, Cohen-Williams, Mary, Josein, Hubert, Hyde, Lynn, Lee, Julie, McKittrick, Brian, Song, Lixin, Terracina, Giuseppe, Voigt, Johannes, Zhang, Lili, Zhu, Zhaoning

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-a converting enzyme inhibitors. Part II: Optimization of the S3' pocket von MAZZOLA, Robert D, ZHAONING ZHU, ORTH, Peter, MADISON, Vincent, JING SUN, LUNDELL, Daniel, XIAODA NIU, SINNING, Lisa, MCKITTRICK, Brian, LAVEY, Brian, SPITLER, James, KOZLOWSKI, Joseph, NENG-YANG, Shih, GUOWEI ZHOU, ZHUYAN GUO

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Discovery of novel hydroxamates as highly potent tumor necrosis factor-[alpha] converting enzyme inhibitors. Part II: Optimization of the S3′ pocket von Mazzola Jr., Robert D., Zhu, Zhaoning, Sinning, Lisa, McKittrick, Brian, Lavey, Brian, Spitler, James, Kozlowski, Joseph, Neng-Yang, Shih, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Sun, Jing, Lundell, Daniel, Niu, Xiaoda

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AZABICYCLO[4.1.0]HEPTANE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR von CLAUSEN, Dane James, KOZLOWSKI, Joseph, A, MAZZOLA, Robert, D., Jr, LIU, Ping, FELLS, James, I

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HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR von BAO, Jianming, LO, Michael Man-Chu, FERGUSON, Ronald, KNOWLES, Sandra, L, GAO, Xiaolei, HARRISON, Scott, SCHUBERT, Jeffrey, W, MAZZOLA, Robert, D., Jr

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6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR von LO, Michael Man-Chu, TONG, Ling, LI, Chunsing, KNOWLES, Sandra, L, GAO, Xiaolei, MAZZOLA, Robert, D., Jr

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AZABICYCLO[4.1.0]HEPTANE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR von CLAUSEN, Dane James, KOZLOWSKI, Joseph, A, MAZZOLA, Robert, D., Jr, LIU, Ping, FELLS, James, I

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