Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3 von Disch, Jeremy S, Evindar, Ghotas, Chiu, Cynthia H, Blum, Charles A, Dai, Han, Jin, Lei, Schuman, Eli, Lind, Kenneth E, Belyanskaya, Svetlana L, Deng, Jianghe, Coppo, Frank, Aquilani, Leah, Graybill, Todd L, Cuozzo, John W, Lavu, Siva, Mao, Cheney, Vlasuk, George P, Perni, Robert B

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Crystallographic structure of a small molecule SIRT1 activator-enzyme complex von Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes von Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei

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VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells von KAI LIN, PERNI, Robert B, KWONG, Ann D, CHAO LIN

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Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes von Jin, Lei, Wei, Wentao, Jiang, Yaobin, Peng, Hao, Cai, Jianhua, Mao, Chen, Dai, Han, Choy, Wendy, Bemis, Jean E., Jirousek, Michael R., Milne, Jill C., Westphal, Christoph H., Perni, Robert B.

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Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease von PERNI, Robert B, ALMQUIST, Susan J, HEISER, Angela, KALKERI, Gururaj, KOLACZKOWSKI, Elaine, KAI LIN, LUONG, Yu-Ping, GOVINDA RAO, B, TAYLOR, William P, THOMSON, John A, TUNG, Roger D, YUNYI WEI, BYRN, Randal A, KWONG, Ann D, CHAO LIN, CHANDORKAR, Gurudatt, CHATURVEDI, Pravin R, COURTNEY, Lawrence F, DECKER, Caroline J, DINEHART, Kirk, GATES, Cynthia A, HARBESON, Scott L

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SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging von Blum, Charles A, Ellis, James L, Loh, Christine, Ng, Pui Yee, Perni, Robert B, Stein, Ross L

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Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3 von Jin, Lei, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Morrison, Michael, Xia, Yu, Wang, Xiaohong, Xu, Yihua, Yang, Yuecheng, Smith, Jesse J., Hoffmann, Ethan, Carney, David P., Perni, Robert B., Jirousek, Michael R., Bemis, Jean E., Milne, Jill C., Sinclair, David A., Westphal, Christoph H.

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In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061 von Lin, Chao, Gates, Cynthia A., Rao, B. Govinda, Brennan, Debra L., Fulghum, John R., Luong, Yu-Ping, Frantz, J. Daniel, Lin, Kai, Ma, Sue, Wei, Yun-Yi, Perni, Robert B., Kwong, Ann D.

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Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators von Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.

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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators von Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Yen E, Sook, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.

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SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR von Dai, Han, Kustigian, Lauren, Carney, David, Case, April, Considine, Thomas, Hubbard, Basil P, Perni, Robert B, Riera, Thomas V, Szczepankiewicz, Bruce, Vlasuk, George P, Stein, Ross L

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Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5 von Szczepankiewicz, Bruce G, Dai, Han, Koppetsch, Karsten J, Qian, Dongming, Jiang, Fan, Mao, Cheney, Perni, Robert B

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Inhibition of Human Hepatitis B Virus Replication by AT-61, a Phenylpropenamide Derivative, Alone and in Combination with (−)β-l-2′,3′-Dideoxy-3′-Thiacytidine von King, R W, Ladner, S K, Miller, T J, Zaifert, K, Perni, R B, Conway, S C, Otto, M J

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A synthetic approach to (±)-aristomakine von Perni, Robert B., Gribble, Gordon W.

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In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms von Lin, Chao, Lin, Kai, Luong, Yu-Ping, Rao, B Govinda, Wei, Yun-Yi, Brennan, Debra L, Fulghum, John R, Hsiao, Hsun-Mei, Ma, Sue, Maxwell, John P, Cottrell, Kevin M, Perni, Robert B, Gates, Cynthia A, Kwong, Ann D

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Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators von Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B

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In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in Rats von Maltais, François, Jung, Young Chun, Chen, Minzhang, Tanoury, Jerry, Perni, Robert B, Mani, Nagraj, Laitinen, Leena, Huang, Hui, Liao, Shengkai, Gao, Hongying, Tsao, Hong, Block, Eric, Ma, Chien, Shawgo, Rebecca S, Town, Christopher, Brummel, Christopher L, Howe, David, Pazhanisamy, S, Raybuck, Scott, Namchuk, Mark, Bennani, Youssef L

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The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry von Broom, Toby, Hughes, Mark, Szczepankiewicz, Bruce G., Ace, Karl, Hagger, Ben, Lacking, Gary, Chima, Ranjit, Marchbank, Graeme, Alford, Gareth, Evans, Paul, Cunningham, Christopher, Roberts, John C., Perni, Robert B., Berry, Malcolm, Rutter, Andrew, Watson, Simon A.

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One-Step, Nonenzymatic Synthesis of O-Acetyl-ADP-ribose and Analogues from NAD and Carboxylates von Szczepankiewicz, Bruce G, Koppetsch, Karsten J, Perni, Robert B

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