NanoBRETA Novel BRET Platform for the Analysis of Protein–Protein Interactions von Machleidt, Thomas, Woodroofe, Carolyn C, Schwinn, Marie K, Méndez, Jacqui, Robers, Matthew B, Zimmerman, Kris, Otto, Paul, Daniels, Danette L, Kirkland, Thomas A, Wood, Keith V

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Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action von Riching, Kristin M, Mahan, Sarah, Corona, Cesear R, McDougall, Mark, Vasta, James D, Robers, Matthew B, Urh, Marjeta, Daniels, Danette L

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Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket von Forster, Michael, Chaikuad, Apirat, Bauer, Silke M., Holstein, Julia, Robers, Matthew B., Corona, Cesear R., Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A.

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Application of BRET to monitor ligand binding to GPCRs von Stoddart, Leigh A, Johnstone, Elizabeth K M, Wheal, Amanda J, Goulding, Joëlle, Robers, Matthew B, Machleidt, Thomas, Wood, Keith V, Hill, Stephen J, Pfleger, Kevin D G

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Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate von Hall, Mary P, Unch, James, Binkowski, Brock F, Valley, Michael P, Butler, Braeden L, Wood, Monika G, Otto, Paul, Zimmerman, Kristopher, Vidugiris, Gediminas, Machleidt, Thomas, Robers, Matthew B, Benink, Hélène A, Eggers, Christopher T, Slater, Michael R, Meisenheimer, Poncho L, Klaubert, Dieter H, Fan, Frank, Encell, Lance P, Wood, Keith V

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tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis von Dopfer, Johannes, Vasta, James D., Müller, Susanne, Knapp, Stefan, Robers, Matthew B., Schwalm, Martin P.

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KRAS is vulnerable to reversible switch-II pocket engagement in cells von Vasta, James D., Peacock, D. Matthew, Zheng, Qinheng, Walker, Joel A., Zhang, Ziyang, Zimprich, Chad A., Thomas, Morgan R., Beck, Michael T., Binkowski, Brock F., Corona, Cesear R., Robers, Matthew B., Shokat, Kevan M.

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Quantifying CDK inhibitor selectivity in live cells von Wells, Carrow I., Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Ingold, Morgan R., Pickett, Julie E., Drewry, David H., Pugh, Kathryn M., Schwinn, Marie K., Hwang, Byounghoon (Brian), Zegzouti, Hicham, Huber, Kilian V. M., Cong, Mei, Meisenheimer, Poncho L., Willson, Timothy M., Robers, Matthew B.

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Potent and selective bivalent inhibitors of BET bromodomains von Waring, Michael J, Chen, Huawei, Rabow, Alfred A, Walker, Graeme, Bobby, Romel, Boiko, Scott, Bradbury, Rob H, Callis, Rowena, Clark, Edwin, Dale, Ian, Daniels, Danette L, Dulak, Austin, Flavell, Liz, Holdgate, Geoff, Jowitt, Thomas A, Kikhney, Alexey, McAlister, Mark, Méndez, Jacqui, Ogg, Derek, Patel, Joe, Petteruti, Philip, Robb, Graeme R, Robers, Matthew B, Saif, Sakina, Stratton, Natalie, Svergun, Dmitri I, Wang, Wenxian, Whittaker, David, Wilson, David M, Yao, Yi

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A Method to Conditionally Measure Target Engagement at Intracellular RAS and RAF Complexes von Vasta, James D., Michaud, Ani, Aaron Crapster, J., Robers, Matthew B.

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Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models von Shen, Sida, Hadley, Melissa, Ustinova, Kseniya, Pavlicek, Jiri, Knox, Tessa, Noonepalle, Satish, Tavares, Mauricio T, Zimprich, Chad A, Zhang, Guiping, Robers, Matthew B, Bařinka, Cyril, Kozikowski, Alan P, Villagra, Alejandro

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Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement von Vasta, James D., Corona, Cesear R., Wilkinson, Jennifer, Zimprich, Chad A., Hartnett, James R., Ingold, Morgan R., Zimmerman, Kristopher, Machleidt, Thomas, Kirkland, Thomas A., Huwiler, Kristin G., Ohana, Rachel Friedman, Slater, Michael, Otto, Paul, Cong, Mei, Wells, Carrow I., Berger, Benedict-Tilman, Hanke, Thomas, Glas, Carina, Ding, Ke, Drewry, David H., Huber, Kilian V.M., Willson, Timothy M., Knapp, Stefan, Müller, Susanne, Meisenheimer, Poncho L., Fan, Frank, Wood, Keith V., Robers, Matthew B.

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Target engagement and drug residence time can be observed in living cells with BRET von Robers, Matthew B., Dart, Melanie L., Woodroofe, Carolyn C., Zimprich, Chad A., Kirkland, Thomas A., Machleidt, Thomas, Kupcho, Kevin R., Levin, Sergiy, Hartnett, James R., Zimmerman, Kristopher, Niles, Andrew L., Ohana, Rachel Friedman, Daniels, Danette L., Slater, Michael, Wood, Monika G., Cong, Mei, Cheng, Yi-Qiang, Wood, Keith V.

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Binding Kinetics Survey of the Drugged Kinome von Georgi, Victoria, Schiele, Felix, Berger, Benedict-Tilman, Steffen, Andreas, Marin Zapata, Paula A, Briem, Hans, Menz, Stephan, Preusse, Cornelia, Vasta, James D, Robers, Matthew B, Brands, Michael, Knapp, Stefan, Fernández-Montalván, Amaury

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Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model von Shen, Sida, Picci, Cristina, Ustinova, Kseniya, Benoy, Veronick, Kutil, Zsófia, Zhang, Guiping, Tavares, Maurício T, Pavlíček, Jiří, Zimprich, Chad A, Robers, Matthew B, Van Den Bosch, Ludo, Bařinka, Cyril, Langley, Brett, Kozikowski, Alan P

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Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells von Yang, Xuan, Smith, Jeffery L, Beck, Michael T, Wilkinson, Jennifer M, Michaud, Ani, Vasta, James D, Robers, Matthew B, Willson, Timothy M

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Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance von Lyczek, Agatha, Berger, Benedict-Tilman, Rangwala, Aziz M., Paung, YiTing, Tom, Jessica, Philipose, Hannah, Guo, Jiaye, Albanese, Steven K., Robers, Matthew B., Knapp, Stefan, Chodera, John D., Seeliger, Markus A.

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Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays von Teske, Kelly A., Corona, Cesear, Wilkinson, Jennifer, Mamott, Daniel, Good, David A., Zambrano, Delia, Lazar, Dan F., Cali, James J., Robers, Matthew B., O’Brien, Martha A.

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Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex von Vasta, James D., Michaud, Ani, Zimprich, Chad A., Beck, Michael T., Swiatnicki, Matthew R., Zegzouti, Hicham, Thomas, Morgan R., Wilkinson, Jennifer, Crapster, J. Aaron, Robers, Matthew B.

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Real-Time Ligand Binding of Fluorescent VEGF-A Isoforms that Discriminate between VEGFR2 and NRP1 in Living Cells von Peach, Chloe J., Kilpatrick, Laura E., Friedman-Ohana, Rachel, Zimmerman, Kris, Robers, Matthew B., Wood, Keith V., Woolard, Jeanette, Hill, Stephen J.

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