Treatment of acute lung injury by targeting MG53-mediated cell membrane repair von Jia, Yanlin, Chen, Ken, Lin, Peihui, Lieber, Gissela, Nishi, Miyuki, Yan, Rosalie, Wang, Zhen, Yao, Yonggang, Li, Yu, Whitson, Bryan A., Duann, Pu, Li, Haichang, Zhou, Xinyu, Zhu, Hua, Takeshima, Hiroshi, Hunter, John C., McLeod, Robbie L., Weisleder, Noah, Zeng, Chunyu, Ma, Jianjie

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Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models von Lieber, Gissela B, Fernandez, Xiomara, Mingo, Garfield G, Jia, Yanlin, Caniga, Michael, Gil, Malgorzata A., Keshwani, Shanil, Woodhouse, Janice D., Cicmil, Milenko, Moy, Lily Y, Kelly, Nancy, Jimenez, Johanna, Crawley, Yvette, Anthes, John C, Klappenbach, Joel, Ma, Yu-Lu, McLeod, Robbie L.

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Abstract 2254: Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1 von Methot, Joey L., Zhou, Hua, McGowan, Meredith A., Trotter, Benjamin W., Altman, Michael, Fradera, Xavier, Lesburg, Charles, Li, Chaomin, Alves, Stephen, Chappell, Craig P., Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybil M., Goldenblatt, Peter, Hill, Armetta D., Shaffer, Lynsey, Chen, Dapeng, McLeod, Robbie L., Lee, Hyun-Hee, Shah, Sanjiv, Katz, Jason D.

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Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions von Caniga, Michael, Cabal, Antonio, Mehta, Khamir, Ross, David S, Gil, Malgorzata A, Woodhouse, Janice D, Eckman, Joseph, Naber, John R, Callahan, Marissa K, Goncalves, Luciano, Hill, Susan E, Mcleod, Robbie L, McIntosh, Fraser, Freke, Mark C, Visser, Sandra A G, Johnson, Neil, Salmon, Michael, Cicmil, Milenko

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Efficacy of a NOP1 Agonist (SCH486757) in Subacute Cough von Woodcock, Ashley, McLeod, Robbie L, Sadeh, Jonathan, Smith, Jaclyn A

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Pharmacological Evaluation of Selective α2c-Adrenergic Agonists in Experimental Animal Models of Nasal Congestion von Jia, Yanlin, Mingo, Garfield G., Hunter, John C., Lieber, Gissela B., Palamanda, Jairam R., Mei, Hong, Boyce, Christopher W., Koss, Michael C., Yu, Yongxin, Cicmil, Milenko, Hey, John A., McLeod, Robbie L.

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Discovery of Orally Active 3-Pyridinyl-tropane As a Potent Nociceptin Receptor Agonist for the Management of Cough von Yang, Shu-Wei, Ho, Ginny, Tulshian, Deen, Greenlee, William J, Anthes, John, Fernandez, Xiomara, McLeod, Robbie L, Hey, John A, Xu, Xiaoying

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Anandamide induces cough in conscious guinea‐pigs through VR1 receptors von Jia, Yanlin, McLeod, Robbie L, Wang, Xin, Parra, Leonard E, Egan, Robert W, Hey, John A

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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators von Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D

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The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety von Ho, Ginny D., Anthes, John, Bercovici, Ana, Caldwell, John P., Cheng, Kuo-Chi, Cui, Xiaoming, Fawzi, Ahmad, Fernandez, Xiomara, Greenlee, William J., Hey, John, Korfmacher, Walter, Lu, Sherry X., McLeod, Robbie L., Ng, Fay, Torhan, April Smith, Tan, Zheng, Tulshian, Deen, Varty, Geoffrey B., Xu, Xiaoying, Zhang, Hongtao

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Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability von Methot, Joey L, Zhou, Hua, Kattar, Sam D, McGowan, Meredeth A, Wilson, Kevin, Garcia, Yudith, Deng, Yongi, Altman, Michael, Fradera, Xavier, Lesburg, Charles, Fischmann, Thierry, Li, Chaomin, Alves, Steve, Shah, Sanjiv, Fernandez, Rafael, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vince, McLeod, Robbie L, Yu, Hongshi, Bass, Alan, Kemper, Ray, Gatto, Nicholas T, LaFranco-Scheuch, Lisa, Trotter, Benjamin Wesley, Guzi, Timothy, Katz, Jason D

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Characterizing Pharmacokinetic–Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation von McLeod, Robbie L, Gil, Malgorzata A, Chen, Dapeng, Cabal, Antonio, Katz, Jason, Methot, Joey, Woodhouse, Janice D, Dorosh, Lauren, Geda, Prasanthi, Mehta, Khamir, Cicmil, Milenko, Baltus, Gretchen A, Bass, Alan, Houshyar, Hani, Caniga, Michael, Yu, Hongshi, Gervais, Francois, Alves, Stephen, Shah, Sanjiv

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Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80 von McLeod, Robbie L, Mingo, Garfield G, Kreutner, William, Hey, John A

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Where Are the New Cough Treatments: A Debriefing of Recent Clinical Proof-of-Concept Trials with the NOP Agonist SCH 486757 von McLeod, Robbie L., Tulshian, Deen B., Sadeh, Jonathan

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Characterization of murine CEACAM1 in vivo reveals low expression on CD8 + T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1 von McLeod, Robbie L, Angagaw, Minilik H, Baral, Toya Nath, Liu, Liming, Moniz, Raymond Joseph, Laskey, Jason, Hsieh, SuChun, Lee, Mike, Han, Jin-Hwan, Issafras, Hassan, Javaid, Sarah, Loboda, Andrey, Sadekova, Svetlana, O'Connor, Joann A, Tse, Archie, Punnonen, Juha

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Alpha-2c-Adrenergic Receptors Contribute to Basal Nasal Patency in the Anesthetized Cat von Mingo, Garfield G., Corboz, Michel R., Salisbury, Brian G., McCormick, Kevin D., Boyce, Christopher W., Mukhopadhyay, Gitali, McLeod, Robbie L.

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Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary... von Gil, Malgorzata A., Caniga, Michael, Woodhouse, Janice D., Eckman, Joseph, Lee, Hyun-Hee, Salmon, Michael, Naber, John, Hamilton, Valerie T., Sevilla, Raquel S., Bettano, Kimberly, Klappenbach, Joel, Moy, Lily, Correll, Craig C., Gervais, Francois G., Siliphaivanh, Phieng, Zhang, Weisheng, Zhang-Hoover, Jie, McLeod, Robbie L., Cicmil, Milenko

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Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis von Chakravarthy, Kalyan, Faltus, Robert, Robinson, Gain, Sevilla, Raquel, Shin, John, Zielstorff, Mark, Byford, Alan, Leccese, Erica, Caniga, Michael J, Hseih, SuChun, Zhang, Shuli, Chiu, Chi-Sung, Zhang-Hoover, Jie, Moy, Lily Y, McLeod, Robbie L, Stoffregen, Dana, Zhang, Weisheng, Murtaza, Anwar, Cicmil, Milenko

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TRPV1 Antagonists as Potential Antitussive Agents von McLeod, Robbie L., Correll, Craig C., Jia, Yanlin, Anthes, John C.

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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical mod... von McLeod, Robbie L., Tulshian, Deen B., Bolser, Donald C., Varty, Geoffrey B., Baptista, Marco, Fernandez, Xiomara, Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Ho, Ginny D., Jia, Yanlin, Ng, Fay W., Korfmacher, Walter, Xu, Xiaoying, Veals, John, Smith-Torhan, April, Wainhaus, Samuel, Fawzi, Ahmad B., Austin, Theodore M., van Heek, Margaret, Hey, John A.

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