Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition von Rizq, Ola, Mimura, Naoya, Oshima, Motohiko, Saraya, Atsunori, Koide, Shuhei, Kato, Yuko, Aoyama, Kazumasa, Nakajima-Takagi, Yaeko, Wang, Changshan, Chiba, Tetsuhiro, Ma, Anqi, Jin, Jian, Iseki, Tohru, Nakaseko, Chiaki, Iwama, Atsushi

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The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells von Miyagi, Satoru, Sroczynska, Patrycja, Kato, Yuko, Nakajima-Takagi, Yaeko, Oshima, Motohiko, Rizq, Ola, Takayama, Naoya, Saraya, Atsunori, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Matsuzaki, Yumi, Christensen, Jesper, Helin, Kristian, Iwama, Atsushi

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The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells von Nagai, Yurie, Mimura, Naoya, Rizq, Ola, Isshiki, Yusuke, Oshima, Motohiko, Rizk, Mohamed, Saraya, Atsunori, Koide, Shuhei, Nakajima-Takagi, Yaeko, Miyota, Makiko, Chiba, Tetsuhiro, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Mitsukawa, Shio, Takeda, Yusuke, Ohwada, Chikako, Takeuchi, Masahiro, Iseki, Tohru, Nakaseko, Chiaki, Lennox, William, Sheedy, Josephine, Weetall, Marla, Yokote, Koutaro, Iwama, Atsushi, Sakaida, Emiko

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Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma von Rizk, Mohamed, Rizq, Ola, Oshima, Motohiko, Nakajima‐Takagi, Yaeko, Koide, Shuhei, Saraya, Atsunori, Isshiki, Yusuke, Chiba, Tetsuhiro, Yamazaki, Satoshi, Ma, Anqi, Jin, Jian, Iwama, Atsushi, Mimura, Naoya

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EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma von Kusakabe, Yuko, Chiba, Tetsuhiro, Oshima, Motohiko, Koide, Shuhei, Rizq, Ola, Aoyama, Kazumasa, Ao, Junjie, Kaneko, Tatsuya, Kanzaki, Hiroaki, Kanayama, Kengo, Maeda, Takahiro, Saito, Tomoko, Nakagawa, Ryo, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Ogasawara, Sadahisa, Suzuki, Eiichiro, Nakamoto, Shingo, Yasui, Shin, Mikata, Rintaro, Muroyama, Ryosuke, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Jun, Mimura, Naoya, Ma, Anqi, Jin, Jian, Zen, Yoh, Otsuka, Masayuki, Kaneda, Atsushi, Iwama, Atsushi, Kato, Naoya

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PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome von Aoyama, Kazumasa, Shinoda, Daisuke, Suzuki, Emi, Nakajima-Takagi, Yaeko, Oshima, Motohiko, Koide, Shuhei, Rizq, Ola, Si, Sha, Tara, Shiro, Sashida, Goro, Iwama, Atsushi

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Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition von MIMURA, Naoya, HIDESHIMA, Teru, CIRSTEA, Diana, GORGUN, Gullu, MINAMI, Jiro, TAI, Yu-Tzu, RICHARDSON, Paul G, UTSUGI, Teruhiro, IWAMA, Atsushi, ANDERSON, Kenneth C, SHIMOMURA, Toshiyasu, SUZUKI, Rikio, OHGUCHI, Hiroto, RIZQ, Ola, KIKUCHI, Shohei, YOSHIDA, Yasuhiro, COTTINI, Francesca, JAKUBIKOVA, Jana

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Genetic and transcriptional landscape of plasma cells in POEMS syndrome von Nagao, Yuhei, Mimura, Naoya, Takeda, June, Yoshida, Kenichi, Shiozawa, Yusuke, Oshima, Motohiko, Aoyama, Kazumasa, Saraya, Atsunori, Koide, Shuhei, Rizq, Ola, Hasegawa, Yoshinori, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Nishijima, Dai, Isshiki, Yusuke, Kayamori, Kensuke, Kawajiri-Manako, Chika, Oshima-Hasegawa, Nagisa, Tsukamoto, Shokichi, Mitsukawa, Shio, Takeda, Yusuke, Ohwada, Chikako, Takeuchi, Masahiro, Iseki, Tohru, Misawa, Sonoko, Miyano, Satoru, Ohara, Osamu, Yokote, Koutaro, Sakaida, Emiko, Kuwabara, Satoshi, Sanada, Masashi, Iwama, Atsushi, Ogawa, Seishi, Nakaseko, Chiaki

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Expression of Gata1s Followed By Stag2 Deficiency Promotes Abnormal Megakaryocytopoiesis and Induces Lethal Myelofibrosis von Suzuki, Yutaro, Nakajima-Takagi, Yaeko, Kurosawa, Shuhei, Rizq, Ola, Kon, Ayana, Ito, Etsuro, Ogawa, Seishi, Iwama, Atsushi

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3024 – PRC2 INSUFFICIENCY CAUSES DYSERYTHROPOIESIS THAT IS DEPENDENT ON CDKN2A DEREPRESSION AND P53 ACTIVATION IN MDS von Aoyama, Kazumasa, Kaito, Satoshi, Koide, Shuhei, Rizq, Ola, Nakajima-Takagi, Yaeko, Oshima, Motohiko, Iwama, Atsushi

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3186 – STAG2 AND EZH2 DEFICIENCY COLLABORATES WITH GATA1S IN THE INDUCTION OF ABNORMAL MEGAKARYOCYTOPOIESIS ASSOCIATED WITH DOWN SYNDROME-RELATED LEUKEMIA von Suzuki, Yutaro, Nakajima-Takagi, Yaeko, Kurosawa, Shuhei, Rizq, Ola, Ochi, Yotaro, Kon, Ayana, Ito, Etsuro, Ogawa, Seishi, Iwama, Atsushi

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Correction: UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease von Rizq, Ola, Mimura, Naoya, Oshima, Motohiko, Momose, Shuji, Takayama, Naoya, Itokawa, Naoki, Koide, Shuhei, Shibamiya, Asuka, Miyamoto-Nagai, Yurie, Rizk, Mohamed, Nakajima-Takagi, Yaeko, Aoyama, Kazumasa, Wang, Changshan, Saraya, Atsunori, Ito, Ryoji, Seimiya, Masanori, Watanabe, Mariko, Yamasaki, Satoshi, Shibata, Tatsuhiro, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Chiba, Tetsuhiro, Sakaida, Emiko, Nakaseko, Chiaki, Tamaru, Jun-ichi, Tai, Yu-Tzu, Anderson, Kenneth C., Honda, Hiroaki, Iwama, Atsushi

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UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease von Rizq, Ola, Mimura, Naoya, Oshima, Motohiko, Momose, Shuji, Takayama, Naoya, Itokawa, Naoki, Koide, Shuhei, Shibamiya, Asuka, Miyamoto-Nagai, Yurie, Rizk, Mohamed, Nakajima-Takagi, Yaeko, Aoyama, Kazumasa, Wang, Changshan, Saraya, Atsunori, Ito, Ryoji, Seimiya, Masanori, Watanabe, Mariko, Yamasaki, Satoshi, Shibata, Tatsuhiro, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Chiba, Tetsuhiro, Sakaida, Emiko, Nakaseko, Chiaki, Tamaru, Jun-ichi, Tai, Yu-Tzu, Anderson, Kenneth C., Honda, Hiroaki, Iwama, Atsushi

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Exhausted T Cells Characterized By Upregulation of Specific Transcription Factors Are Increased in a Mouse Model of De Novo Mature B Cell Neoplasms von Shibamiya, Asuka, Mimura, Naoya, Miyamoto-Nagai, Yurie, Koide, Shuhei, Oshima, Motohiko, Rizq, Ola, Aoyama, Kazumasa, Nakajima-Takagi, Yaeko, Kayamori, Kensuke, Isshiki, Yusuke, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Takeda, Yusuke, Koyama-Nasu, Ryo, Chiba, Tetsuhiro, Honda, Hiroaki, Yokote, Koutaro, Iwama, Atsushi, Sakaida, Emiko

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Akt Inhibition Differently Controls PRC2 Components and Synergizes with Dual EZH2/1 Inhibitor in the Treatment of Multiple Myeloma von Rizk, Mohamed, Rizq, Ola, Oshima, Motohiko, Nakajima-Takagi, Yaeko, Koide, Shuhei, Saraya, Atsunori, Isshiki, Yusuke, Chiba, Tetsuhiro, Yamazaki, Satoshi, Ma, Anqi, Jin, Jian, Iwama, Atsushi, Mimura, Naoya

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The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms von Shibamiya, Asuka, Miyamoto-Nagai, Yurie, Koide, Shuhei, Oshima, Motohiko, Rizq, Ola, Aoyama, Kazumasa, Nakajima-Takagi, Yaeko, Kato, Rei, Kayamori, Kensuke, Isshiki, Yusuke, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Takeda, Yusuke, Koyama-Nasu, Ryo, Chiba, Tetsuhiro, Honda, Hiroaki, Yokote, Koutaro, Iwama, Atsushi, Sakaida, Emiko, Mimura, Naoya

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Syndecan-1 Is Critical in ARF6-Dependent Macropinocytosis Driven By KRAS Mutation in the Pathophysiology of Multiple Myeloma von Yu, Tengteng, Lin, Liang, Wen, Kenneth, Xing, Lijie, Liu, Jiye, Cho, Shih-Feng, Hsieh, Phillip, Rizq, Ola, Li, Yuyin, Yu, Liang, Wu, Xiang, Morelli, Eugenio, Xu, Yan, An, Gang, Munshi, Nikhil C., Qiu, Lugui, Anderson, Kenneth C., Tai, Yu-Tzu

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Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice von Rizq, Ola, Mimura, Naoya, Oshima, Motohiko, Momose, Shuji, Nakajima-Takagi, Yaeko, Aoyama, Kazumasa, Saraya, Atsunori, Iseki, Tohru, Sakaida, Emiko, Nakaseko, Chiaki, Okuno, Yutaka, Honda, Hiroaki, Tamaru, Jun-ichi, Iwama, Atsushi

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The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma von Nagai, Yurie, Mimura, Naoya, Rizq, Ola, Isshiki, Yusuke, Oshima, Motohiko, Rizk, Mohamed, Saraya, Atsunori, Koide, Shuhei, Nakajima-Takagi, Yaeko, Miyota, Makiko, Oshima-Hasegawa, Nagisa, Tsukamoto, Shokichi, Mitsukawa, Shio, Takeda, Yusuke, Ohwada, Chikako, Takeuchi, Masahiro, Iseki, Tohru, Nakaseko, Chiaki, Sheedy, Josephine, Weetall, Marla, Iwama, Atsushi, Sakaida, Emiko

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EZH2 Inhibition and the Combination with Proteasome Inhibition Are Novel Potential Strategies for the Treatment of Multiple Myeloma von Rizq, Ola, Mimura, Naoya, Koide, Shuhei, Ma, Anqi, Jin, Jian, Iseki, Tohru, Nakaseko, Chiaki, Iwama, Atsushi

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