Discovery and Evaluation of Potent P1 Aryl Heterocycle-Based Thrombin Inhibitors von Young, Mary Beth, Barrow, James C, Glass, Kristen L, Lundell, George F, Newton, Christina L, Pellicore, Janetta M, Rittle, Kenneth E, Selnick, Harold G, Stauffer, Kenneth J, Vacca, Joseph P, Williams, Peter D, Bohn, Dennis, Clayton, Franklin C, Cook, Jacquelynn J, Krueger, Julie A, Kuo, Lawrence C, Lewis, S. Dale, Lucas, Bobby J, McMasters, Daniel R, Miller-Stein, Cynthia, Pietrak, Beth L, Wallace, Audrey A, White, Rebecca B, Wong, Bradley, Yan, Youwei, Nantermet, Philippe G

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Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 von Barrow, James C., Rittle, Kenneth E., Ngo, Phung L., Selnick, Harold G., Graham, Samuel L., Pitzenberger, Steven M., McGaughey, Georgia B., Colussi, Dennis, Lai, Ming-Tain, Huang, Qian, Tugusheva, Katherine, Espeseth, Amy S., Simon, Adam J., Munshi, Sanjeev K., Vacca, Joseph P.

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Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels von Yang, Zhi-Qiang, Barrow, James C, Shipe, William D, Schlegel, Kelly-Ann S, Shu, Youheng, Yang, F. Vivien, Lindsley, Craig W, Rittle, Kenneth E, Bock, Mark G, Hartman, George D, Uebele, Victor N, Nuss, Cindy E, Fox, Steve V, Kraus, Richard L, Doran, Scott M, Connolly, Thomas M, Tang, Cuyue, Ballard, Jeanine E, Kuo, Yuhsin, Adarayan, Emily D, Prueksaritanont, Thomayant, Zrada, Matthew M, Marino, Michael J, Graufelds, Valerie Kuzmick, DiLella, Anthony G, Reynolds, Ian J, Vargas, Hugo M, Bunting, Patricia B, Woltmann, Richard F, Magee, Michael M, Koblan, Kenneth S, Renger, John J

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Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase von Barrow, James C, Stauffer, Shaun R, Rittle, Kenneth E, Ngo, Phung L, Yang, ZhiQiang, Selnick, Harold G, Graham, Samuel L, Munshi, Sanjeev, McGaughey, Georgia B, Holloway, M. Katharine, Simon, Adam J, Price, Eric A, Sankaranarayanan, Sethu, Colussi, Dennis, Tugusheva, Katherine, Lai, Ming-Tain, Espeseth, Amy S, Xu, Min, Huang, Qian, Wolfe, Abigail, Pietrak, Beth, Zuck, Paul, Levorse, Dorothy A, Hazuda, Daria, Vacca, Joseph P

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Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists von Uebele, Victor N, Nuss, Cindy E, Fox, Steven V, Garson, Susan L, Cristescu, Razvan, Doran, Scott M, Kraus, Richard L, Santarelli, Vincent P, Li, Yuxing, Barrow, James C, Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Rittle, Kenneth E, Reger, Thomas S, Bednar, Rodney A, Lemaire, Wei, Mullen, Faith A, Ballard, Jeanine E, Tang, Cuyue, Dai, Ge, McManus, Owen B, Koblan, Kenneth S, Renger, John J

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Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists von Schlegel, Kelly-Ann S., Yang, Zhi-Qiang, Reger, Thomas S., Shu, Youheng, Cube, Rowena, Rittle, Kenneth E., Bondiskey, Phung, Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Kraus, Richard L., Li, Yuxing, Uebele, Victor N., Renger, John J., Barrow, James C.

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Pyridyl amides as potent inhibitors of T-type calcium channels von Reger, Thomas S., Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Mattern, Christa, Cube, Rowena, Rittle, Kenneth E., McGaughey, Georgia B., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Li, Yuxing, Kraus, Richard L., Uebele, Victor N., Renger, John J., Barrow, James C.

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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation von Stauffer, Shaun R., Stanton, Matthew G., Gregro, Alison R., Steinbeiser, Melissa A., Shaffer, Jennifer R., Nantermet, Philippe G., Barrow, James C., Rittle, Kenneth E., Collusi, Dennis, Espeseth, Amy S., Lai, Ming-Tain, Pietrak, Beth L., Holloway, M. Katharine, McGaughey, Georgia B., Munshi, Sanjeev K., Hochman, Jerome H., Simon, Adam J., Selnick, Harold G., Graham, Samuel L., Vacca, Joseph P.

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Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists von Barrow, James C, Rittle, Kenneth E, Reger, Thomas S, Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E, Doran, Scott M, Fox, Steven V, Garson, Susan L, Kraus, Richard L, Li, Yuxing, Marino, Michael J, Kuzmick Graufelds, Valerie, Uebele, Victor N, Renger, John J

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Orally active, nonpeptide oxytocin antagonists von Evans, Ben E, Leighton, James L, Rittle, Kenneth E, Gilbert, Kevin F, Lundell, George F, Gould, Norman P, Hobbs, Doug W, DiPardo, Robert M, Veber, Daniel F, Pettibone, Douglas J, Clineschmidt, Bradley V, Anderson, Paul S, Freidinger, Roger M

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A stereocontrolled synthesis of hydroxyethylene dipeptide isosteres using novel, chiral aminoalkyl epoxides and .gamma.-(aminoalkyl)-.gamma.-lactones von Evans, Ben E, Rittle, Kenneth E, Homnick, Carl F, Springer, James P, Hirshfield, Jordan, Veber, Daniel F

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Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist von Shipe, William D, Barrow, James C, Yang, Zhi-Qiang, Lindsley, Craig W, Yang, F. Vivien, Schlegel, Kelly-Ann S, Shu, Youheng, Rittle, Kenneth E, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine E, Kuo, Yuhsin, Adarayan, Emily D, Prueksaritanont, Thomayant, Zrada, Matthew M, Uebele, Victor N, Nuss, Cindy E, Connolly, Thomas M, Doran, Scott M, Fox, Steven V, Kraus, Richard L, Marino, Michael J, Graufelds, Valerie Kuzmick, Vargas, Hugo M, Bunting, Patricia B, Hasbun-Manning, Martha, Evans, Rose M, Koblan, Kenneth S, Renger, John J

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In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia von Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Rittle, Kenneth E, Gilbert, Kevin F, Steele, Thomas G, Homnick, Carl F, Freidinger, Roger M, Ransom, Rick W, Kling, Paul, Reiss, Duane, Broten, Theodore P, Schorn, Terry W, Chang, Raymond S. L, O'Malley, Stacey S, Olah, Timothy V, Ellis, Joan D, Barrish, Andrea, Kassahun, Kelem, Leppert, Paula, Nagarathnam, Dhanapalan, Forray, Carlos

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Benzodiazepine gastrin and brain cholecystokinin receptor ligands; L-365,260 von Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Veber, Daniel F, Anderson, Paul S, Freidinger, Roger M

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Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position von RITTLE, Kenneth E, BARROW, James C, NANTERMET, Philippe G, NEWTON, Christina L, SANDERS, William M, YOUWEI YAN, VACCA, Joseph P, SELNICK, Harold G, CUTRONA, Kellie J, GLASS, Kristen L, KRUEGER, Julie A, KUO, Lawrence C, LEWIS, S. Dale, LUCAS, Bobby J, MCMASTERS, Daniel R, MORRISSETTE, Matthew M

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Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1) von Nantermet, Philippe G, Barrow, James C, Lundell, George F, Pellicore, Janetta M, Rittle, Kenneth E, Young, MaryBeth, Freidinger, Roger M, Connolly, Thomas M, Condra, Cindra, Karczewski, Jerzy, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Prendergast, Kris, Selnick, Harold G

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Development of 1,4-benzodiazepine cholecystokinin type B antagonists von Bock, Mark G, DiPardo, Robert M, Evans, Ben E, Rittle, Kenneth E, Whitter, Willie L, Garsky, Victor M, Gilbert, Kevin F, Leighton, James L, Carson, Kenneth L

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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia von Barrow, J C, Nantermet, P G, Selnick, H G, Glass, K L, Rittle, K E, Gilbert, K F, Steele, T G, Homnick, C F, Freidinger, R M, Ransom, R W, Kling, P, Reiss, D, Broten, T P, Schorn, T W, Chang, R S, O'Malley, S S, Olah, T V, Ellis, J D, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C

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Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors von Young, Mary Beth, Barrow, James C., Glass, Kristen L., Lundell, George F., Newton, Christina L., Pellicore, Janetta M., Rittle, Kenneth E., Selnick, Harold G., Stauffer, Kenneth J., Vacca, Joseph P., Williams, Peter D., Bohn, Dennis, Clayton, Franklin C., Cook, Jacquelynn J., Krueger, Julie A., Kuo, Lawrence C., Lewis, S. Dale, Lucas, Bobby J., McMasters, Daniel R., Miller-Stein, Cynthia, Pietrak, Beth L., Wallace, Audrey A., White, Rebecca B., Wong, Bradley, Yan, Youwei, Nantermet, Philippe G.

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Nanomolar-affinity, non-peptide oxytocin receptor antagonists von Evans, Ben E, Lundell, George F, Gilbert, Kevin F, Bock, Mark G, Rittle, Kenneth E, Carroll, Leigh Anne, Williams, Peter D, Pawluczyk, Joseph M, Leighton, James L

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