The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design? von Ritchie, Timothy J., Macdonald, Simon J.F.

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The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types von Ritchie, Timothy J., Macdonald, Simon J.F., Young, Robert J., Pickett, Stephen D.

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The developability of heteroaromatic and heteroaliphatic rings - do some have a better pedigree as potential drug molecules than others? von Ritchie, Timothy J, Macdonald, Simon J. F, Peace, Simon, Pickett, Stephen D, Luscombe, Christopher N

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The graphical representation of ADME-related molecule properties for medicinal chemists von Ritchie, Timothy J., Ertl, Peter, Lewis, Richard

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Analysis of the Calculated Physicochemical Properties of Respiratory Drugs: Can We Design for Inhaled Drugs Yet? von Ritchie, Timothy J, Luscombe, Christopher N, Macdonald, Simon J. F

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Physicochemical descriptors of aromatic character and their use in drug discovery von Ritchie, Timothy J, Macdonald, Simon J F

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How drug-like are ‘ugly’ drugs: do drug-likeness metrics predict ADME behaviour in humans? von Ritchie, Timothy J., Macdonald, Simon J.F.

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Heterocyclic replacements for benzene: Maximising ADME benefits by considering individual ring isomers von Ritchie, Timothy J., Macdonald, Simon J.F.

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Physicochemical Descriptors of Aromatic Character and Their Use in Drug Discovery: Miniperspective von Ritchie, Timothy J, Macdonald, Simon J. F

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Should medicinal chemists do molecular modelling? von Ritchie, Timothy J., McLay, Iain M.

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Potent and Orally Bioavailable Non-Peptide Antagonists at the Human Bradykinin B1 Receptor Based on a 2-Alkylamino-5-sulfamoylbenzamide Core von Ritchie, Timothy J, Dziadulewicz, Edward K, Culshaw, Andrew J, Müller, Werner, Burgess, Gillian M, Bloomfield, Graham C, Drake, Gillian S, Dunstan, Andrew R, Beattie, David, Hughes, Glyn A, Ganju, Pam, McIntyre, Peter, Bevan, Stuart J, Davis, Clare, Yaqoob, Mohammed

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Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists von Cole, Andrew G., Metzger, Axel, Brescia, Marc-Raleigh, Qin, Lan-Ying, Appell, Kenneth C., Brain, Christopher T., Hallett, Allan, Ganju, Pam, Denholm, Alastair A., Wareing, James R., Ritchie, Timothy J., Drake, Gillian M., Bevan, Stuart J., MacGloinn, Aisling, McBryde, Andrew, Patel, Viral, Oakley, Paul J., Nunez, Ximena, Gstach, Hubert, Schneider, Peter, Baldwin, John J., Dolle, Roland E., McDonald, Edward, Henderson, Ian

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Bradyzide, a potent non‐peptide B2 bradykinin receptor antagonist with long‐lasting oral activity in animal models of inflammatory hyperalgesia von Burgess, Gillian M, Perkins, Martin N, Rang, Humphrey P, Campbell, Elizabeth A, Brown, Michael C, McIntyre, Peter, Urban, Laszlo, Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Wrigglesworth, Roger, Lee, Wai, Davis, Clare, Phagoo, Steve B, Davis, Andrew J, Phillips, Elsa, Drake, Gillian S, Hughes, Glyn A, Dunstan, Andrew, Bloomfield, Graham C

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Chemoinformatics: manipulating chemical information to facilitate decision-making in drug discovery von Ritchie, Timothy J

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Increasing small molecule drug developability in sub-optimal chemical space von Ritchie, Timothy J., Macdonald, Simon J. F., Peace, Simon, Pickett, Stephen D., Luscombe, Christopher N.

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Nonpeptide Bradykinin B2 Receptor Antagonists:  Conversion of Rodent-Selective Bradyzide Analogues into Potent, Orally-Active Human Bradykinin B2 Receptor Antagonists von Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Davies, John W, Wrigglesworth, Roger, Dunstan, Andrew R, Bloomfield, Graham C, Drake, Gillian S, McIntyre, Peter, Brown, Michael C, Burgess, Gillian M, Lee, Wai, Davis, Clare, Yaqoob, Mohammed, Phagoo, Steve B, Phillips, Elsa, Perkins, Martin N, Campbell, Elizabeth A, Davis, Andrew J, Rang, Humphrey P

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Bradyzide, a potent non‐peptide B 2 bradykinin receptor antagonist with long‐lasting oral activity in animal models of inflammatory hyperalgesia von Burgess, Gillian M, Perkins, Martin N, Rang, Humphrey P, Campbell, Elizabeth A, Brown, Michael C, McIntyre, Peter, Urban, Laszlo, Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Wrigglesworth, Roger, Lee, Wai, Davis, Clare, Phagoo, Steve B, Davis, Andrew J, Phillips, Elsa, Drake, Gillian S, Hughes, Glyn A, Dunstan, Andrew, Bloomfield, Graham C

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1-(2-Nitrophenyl)thiosemicarbazides:  A Novel Class of Potent, Orally Active Non-Peptide Antagonist for the Bradykinin B2 Receptor von Dziadulewicz, Edward K, Ritchie, Timothy J, Hallett, Allan, Snell, Christopher R, Ko, Soo Y, Wrigglesworth, Roger, Hughes, Glyn A, Dunstan, Andrew R, Bloomfield, Graham C, Drake, Gillian S, Brown, Michael C, Lee, Wai, Burgess, Gillian M, Davis, Clare, Yaqoob, Mohammed, Perkins, Martin N, Campbell, Elizabeth A, Davis, Andrew J, Rang, Humphrey P

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The impact of aromatic ring count on compound developability: insights by examining carbo- and hetero-aromatic and -aliphatic ring types von RITCHIE, Timothy J, MACDONALD, Simon J. F, YOUNG, Robert J, PICKETT, Stephen D

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Increasing small molecule drug developability in sub-optimal chemical spaceElectronic supplementary information (ESI) available: Tables containing (a) the average values of all the... von Ritchie, Timothy J, Macdonald, Simon J. F, Peace, Simon, Pickett, Stephen D, Luscombe, Christopher N

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