Targeting the β secretase BACE1 for Alzheimer's disease therapy von Yan, Riqiang, Prof, Vassar, Robert, Prof

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BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions von Hu, Xiangyou, Das, Brati, Hou, Hailong, He, Wanxia, Yan, Riqiang

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Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy von Grumati, Paolo, Morozzi, Giulio, Hölper, Soraya, Mari, Muriel, Harwardt, Marie-Lena Ie, Yan, Riqiang, Müller, Stefan, Reggiori, Fulvio, Heilemann, Mike, Dikic, Ivan

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Role of BACE1 in Alzheimer's synaptic function von Das, Brati, Yan, Riqiang

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Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains von Sharoar, Md Golam, Hu, Xiangyou, Ma, Xin-Ming, Zhu, Xiongwei, Yan, Riqiang

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The case for low-level BACE1 inhibition for the prevention of Alzheimer disease von McDade, Eric, Voytyuk, Iryna, Aisen, Paul, Bateman, Randall J., Carrillo, Maria C., De Strooper, Bart, Haass, Christian, Reiman, Eric M., Sperling, Reisa, Tariot, Pierre N., Yan, Riqiang, Masters, Colin L., Vassar, Robert, Lichtenthaler, Stefan F.

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Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells von Lee, Han-Kyu, Velazquez Sanchez, Clara, Chen, Mei, Morin, Peter J, Wells, John M, Hanlon, Eugene B, Xia, Weiming

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BACE1 controls synaptic function through modulating release of synaptic vesicles von Das, Brati, Singh, Neeraj, Yao, Annie Y., Zhou, John, He, Wanxia, Hu, Xiangyou, Yan, Riqiang

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Ex vivo propagation of synaptically-evoked cortical depolarizations in a mouse model of Alzheimer’s disease at 20 Hz, 40 Hz, or 83 Hz von Patel, Aayushi A., Zhu, Mei Hong, Yan, Riqiang, Antic, Srdjan D.

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Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains von Sharoar, Md Golam, Palko, Sarah, Ge, Yingying, Saido, Takaomi C, Yan, Riqiang

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Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity von Yao, Annie Y, Yan, Riqiang

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Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China von Jiao, Bin, Liu, Xiaoyan, Zhou, Lin, Wang, Maggie Haitian, Zhou, Yafang, Xiao, Tingting, Zhang, Weiwei, Sun, Rui, Waye, Mary Miu Yee, Tang, Beisha, Shen, Lu

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Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer's disease von Huang, Hao, Xiang, Rong, Yan, Riqiang

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A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment von Das, Brati, Yan, Riqiang

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Reversible Overexpression of Bace1 -Cleaved Neuregulin-1 N -Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice von Luo, Xiaoyang, He, Wanxia, Hu, Xiangyou, Yan, Riqiang

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RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer’s brains von Shi, Qi, Ge, Yingying, He, Wanxia, Hu, Xiangyou, Yan, Riqiang

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Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats von Tan, Zhinei, Li, Yongxia, Guan, Yinzheng, Iqbal, Javed, Wang, Chenyue, Yan, Riqiang, Ma, Xin-Ming

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BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides von Zhou, John, Singh, Neeraj, Galske, James, Hudobenko, Jacob, Hu, Xiangyou, Yan, Riqiang

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Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2 von Yan, Riqiang

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Inhibition of BACE1 in glial cells for enhancing clearance of amyloid plaques von Yan, Riqiang

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