Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity von Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.

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Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer von Shimada, Yoshifumi, MD, PhD, Yagi, Ryoma, MD, Kameyama, Hitoshi, MD, PhD, Nagahashi, Masayuki, MD, PhD, Ichikawa, Hiroshi, MD, PhD, Tajima, Yosuke, MD, Okamura, Takuma, MD, PhD, Nakano, Mae, MD, PhD, Nakano, Masato, MD, PhD, Sato, Yo, MD, Matsuzawa, Takeaki, MD, PhD, Sakata, Jun, MD, PhD, Kobayashi, Takashi, MD, PhD, Nogami, Hitoshi, MD, PhD, Maruyama, Satoshi, MD, PhD, Takii, Yasumasa, MD, PhD, Kawasaki, Takashi, MD, PhD, Homma, Kei-ichi, MD, PhD, Izutsu, Hiroshi, Kodama, Keisuke, Ring, Jennifer E., PhD, Protopopov, Alexei, PhD, Lyle, Stephen, MD, PhD, Okuda, Shujiro, PhD, Akazawa, Kohei, PhD, Wakai, Toshifumi, MD, PhD

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Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine von Nagahashi, Masayuki, Wakai, Toshifumi, Shimada, Yoshifumi, Ichikawa, Hiroshi, Kameyama, Hitoshi, Kobayashi, Takashi, Sakata, Jun, Yagi, Ryoma, Sato, Nobuaki, Kitagawa, Yuko, Uetake, Hiroyuki, Yoshida, Kazuhiro, Oki, Eiji, Kudo, Shin-Ei, Izutsu, Hiroshi, Kodama, Keisuke, Nakada, Mitsutaka, Tse, Julie, Russell, Meaghan, Heyer, Joerg, Powers, Winslow, Sun, Ruobai, Ring, Jennifer E, Takabe, Kazuaki, Protopopov, Alexei, Ling, Yiwei, Okuda, Shujiro, Lyle, Stephen

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Pyk2 promotes tumor progression in multiple myeloma von Zhang, Yu, Moschetta, Michele, Huynh, Daisy, Tai, Yu-Tzu, Zhang, Yong, Zhang, Wenjing, Mishima, Yuji, Ring, Jennifer E., Tam, Winnie F., Xu, Qunli, Maiso, Patricia, Reagan, Michaela, Sahin, Ilyas, Sacco, Antonio, Manier, Salomon, Aljawai, Yosra, Glavey, Siobhan, Munshi, Nikhil C., Anderson, Kenneth C., Pachter, Jonathan, Roccaro, Aldo M., Ghobrial, Irene M.

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The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes von Marks, Kevin M, Park, Eun Sun, Arefolov, Alexander, Russo, Katie, Ishihara, Keiko, Ring, Jennifer E, Clardy, Jon, Clarke, Astrid S, Pelish, Henry E

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The α6β4 integrin maintains the survival of human breast carcinoma cells In vivo von LIPSCOMB, Elizabeth A, SIMPSON, Kaylene J, LYLE, Stephen R, RING, Jennifer E, DUGAN, Aisling S, MERCURIO, Arthur M

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PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells von Kolev, Vihren N, Wright, Quentin G, Vidal, Christian M, Ring, Jennifer E, Shapiro, Irina M, Ricono, Jill, Weaver, David T, Padval, Mahesh V, Pachter, Jonathan A, Xu, Qunli

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Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer von Shimada, Yoshifumi, Kameyama, Hitoshi, Nagahashi, Masayuki, Ichikawa, Hiroshi, Muneoka, Yusuke, Yagi, Ryoma, Tajima, Yosuke, Okamura, Takuma, Nakano, Masato, Sakata, Jun, Kobayashi, Takashi, Nogami, Hitoshi, Maruyama, Satoshi, Takii, Yasumasa, Hayashida, Tetsu, Takaishi, Hiromasa, Kitagawa, Yuko, Oki, Eiji, Konishi, Tsuyoshi, Ishida, Fumio, Kudo, Shin-Ei, Ring, Jennifer E, Protopopov, Alexei, Lyle, Stephen, Ling, Yiwei, Okuda, Shujiro, Ishikawa, Takashi, Akazawa, Kohei, Takabe, Kazuaki, Wakai, Toshifumi

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Utility of comprehensive genomic profiling (CGP) for personal cancer vaccine development via neoantigen analysis von Vuzman, Dana, Pei, Shermin, Pantazi, Angeliki, Ring, Jennifer E., Russell, Meaghan, Weeraratne, Dilhan, Lvova, Maria, Lyle, Stephen, Tse, Julie Y

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Abstract 568: FAKPYK2 inhibition enhances immune checkpoint inhibitor efficacy von Wang, Yan, Ring, Jennifer E, Sprott, Kam, Weaver, David T, Pachter, Jonathan A

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Abstract 568: FAK/PYK2 inhibition enhances immune checkpoint inhibitor efficacy von Wang, Yan, Ring, Jennifer E., Sprott, Kam, Weaver, David T., Pachter, Jonathan A.

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Identification of very rare clinically actionable KRAS variants in colorectal cancer patients using a comprehensive large gene panel von Weeraratne, Shyamal Dilhan, Tse, Julie Y, Pantazi, Angeliki, Jiang, Jane, Lvova, Maria, Ring, Jennifer E., Vuzman, Dana, Lyle, Stephen, Russell, Meaghan

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Semi-automated platform for efficient and accurate annotation and interpretation of somatic variants in cancer von Russell, Meaghan, Tse, Julie Y, Pantazi, Angeliki, Bjonnes, Andrew, Pei, Shermin, Vuzman, Dana, Jiang, Jane, Lvova, Maria, Ring, Jennifer E., Lyle, Stephen, Weeraratne, Shyamal Dilhan

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Characterization of tumor mutation burden (TMB) and microsatellite instability (MSI) interplay for gastroesophageal adenocarcinoma (GA) and colorectal carcinoma (CRC) von Huang, Xiu, Tse, Julie Y, Protopopov, Alexei, Russell, Meaghan, Weeraratne, Dilhan, Ring, Jennifer E., Bjonnes, Andrew, Pei, Shermin, Sun, Ruobai, Lvova, Maria, Li, Yajuan, Lyle, Stephen, Vuzman, Dana

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Abstract A191: FAK/PYK2 inhibitors defactinib and VS-4718 enhance immune checkpoint inhibitor efficacy von Ring, Jennifer E., Li, Yajuan, Shapiro, Irina M., Wang, Yan, Weaver, David T., Pachter, Jonathan A.

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Genomic overview of right-sided and left-sided colorectal cancer using comprehensive genomic sequencing von Shimada, Yoshifumi, Kameyama, Hitoshi, Nagahashi, Masayuki, Ichikawa, Hiroshi, Yagi, Ryoma, Tajima, Yosuke, Yuza, Kizuki, Nakano, Masato, Nakajima, Masato, Ishikawa, Takashi, Sakata, Jun, Kobayashi, Takashi, Nogami, Hitoshi, Maruyama, Satoshi, Takii, Yasumasa, Ring, Jennifer E., Lyle, Stephen, Okuda, Shujiro, Takabe, Kazuaki, Wakai, Toshifumi

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Comprehensive genomic sequencing for triple negative breast cancer in Japan von Nagahashi, Masayuki, Hayashida, Tetsu, Kitagawa, Yuko, Futamura, Manabu, Yoshida, Kazuhiro, Kuwayama, Takashi, Nakamura, Seigo, Toshikawa, Chie, Yamauchi, Hideko, Kaneko, Koji, Sato, Nobuaki, Tsuchida, Junko, Yuza, Kizuki, Shimada, Yoshifumi, Ichikawa, Hiroshi, Ring, Jennifer E., Lyle, Stephen, Okuda, Shujiro, Takabe, Kazuaki, Wakai, Toshifumi

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Genomic profiling using a 435-gene panel provides a vision for precision medicine in Japanese gastric cancer von Ichikawa, Hiroshi, Nagahashi, Masayuki, Kitagawa, Yuko, Yoshida, Kazuhiro, Oki, Eiji, Yabusaki, Hiroshi, Nakagawa, Satoru, Sato, Nobuaki, Hanyu, Takaaki, Ishikawa, Takashi, Muneoka, Yusuke, Yuza, Kizuki, Shimada, Yoshifumi, Ring, Jennifer E., Protopopov, Alexei, Lyle, Stephen, Ling, Yiwei, Okuda, Shujiro, Takabe, Kazuaki, Wakai, Toshifumi

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VS-4718, a Potent Focal Adhesion Kinase (FAK) Inhibitor, Exhibits Anticancer Activity in Leukemia Models in Vitro and in Vivo von Tam, Winnie F., Ring, Jennifer E., Trombino, Anthony F., Weaver, David T., Pachter, Jonathan A., Padval, Mahesh, Xu, Qunli

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Abstract 4797: VS-6063 (defactinib) targets cancer stem cells directly and through inhibition of tumor-associated macrophages and cytokine production von Pachter, Jonathan A., Ring, Jennifer E., Kolev, Vihren N., Shapiro, Irina M., Vidal, Christian M., Padval, Mahesh V., Xu, Qunli

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