Design, Synthesis, Structure–Function Relationship, Bioconversion, and Pharmacokinetic Evaluation of Ertapenem Prodrugs von Singh, Sheo B, Rindgen, Diane, Bradley, Prudence, Suzuki, Takao, Wang, Nengxue, Wu, Hao, Zhang, Basheng, Wang, Li, Ji, Chongmin, Yu, Hongshi, Soll, Richard M, Olsen, David B, Meinke, Peter T, Nicoll-Griffith, Deborah A

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Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1... von Dwyer, Michael P, Yu, Younong, Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Biju, Purakkattle, Girijavallabhan, Viyyoor, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, Rokosz, Laura L, Kaiser, Bernd, Li, Ge, Wang, Wei, Stauffer, Tara, Ozgur, Lynne, Baldwin, John, Taveras, Arthur G

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Covalent Modifications to 2‘-Deoxyguanosine by 4-Oxo-2-nonenal, a Novel Product of Lipid Peroxidation von Rindgen, Diane, Nakajima, Masaharu, Wehrli, Suzanne, Xu, Keyang, Blair, Ian A

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Characterization of 2‘-Deoxyadenosine Adducts Derived from 4-Oxo-2-nonenal, a Novel Product of Lipid Peroxidation von Lee, Seon Hwa, Rindgen, Diane, Bible, Roy H, Hajdu, Elisabeth, Blair, Ian A

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Synthesis and Characterization of Polycyclic Aromatic Hydrocarbon o-Quinone Depurinating N7-Guanine Adducts von McCoull, Kirsten D, Rindgen, Diane, Blair, Ian A, Penning, Trevor M

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Selective small-molecule inhibition of an RNA structural element von Howe, John A., Wang, Hao, Fischmann, Thierry O., Balibar, Carl J., Xiao, Li, Galgoci, Andrew M., Malinverni, Juliana C., Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M., Mann, Paul A., Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E., Walker, Scott S., Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A., Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G., Zhang, Rumin, Sheth, Payal R., Gill, Charles J., Tang, Haifeng, Roemer, Terry

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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists von Biju, Purakkattle, Taveras, Arthur, Yu, Younong, Zheng, Junying, Chao, Jianhua, Rindgen, Diane, Jakway, James, Hipkin, R. William, Fossetta, James, Fan, Xuedong, Fine, Jay, Qiu, Hongchen, Merritt, J. Robert, Baldwin, John J.

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Synthesis and structure–activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists von Lai, Gaifa, Merritt, J. Robert, He, Zhenmin, Feng, Daming, Chao, Jianhua, Czarniecki, Michael F., Rokosz, Laura L., Stauffer, Tara M., Rindgen, Diane, Taveras, Arthur G.

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Generation of Leads for γ‑Secretase Modulation von Mandal, Mihirbaran, Buevich, Alexei, Caldwell, John P, Hyde, Lynn, Huang, Xianhai, Liu, Xiaoxiang, McKittrick, Brian, Mazzola, Robert D, Pissarnitski, Dmitri, Palani, Anandan, Zhang, Lili, Parker, Eric, Xiao, Li, Rindgen, Diane, Zhu, Zhaoning

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Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety von Mandal, Mihirbaran, Mitra, Kaushik, Grotz, Diane, Lin, Xinjie, Palamanda, Jairam, Kumari, Pramila, Buevich, Alexei, Caldwell, John P, Chen, Xia, Cox, Kathleen, Favreau, Leonard, Hyde, Lynn, Kennedy, Matthew E, Kuvelkar, Reshma, Liu, Xiaoxiang, Mazzola, Robert D, Parker, Eric, Rindgen, Diane, Sherer, Edward, Wang, Hongwu, Zhu, Zhaoning, Stamford, Andrew W, Cumming, Jared N

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Systematic LC/MS metabolite identification in drug discovery von Clarke, N J, Rindgen, D, Korfmacher, W A, Cox, K A

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Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor von Yu, Tao, Zhang, Yonglian, Kerekes, Angela D., Tagat, Jayaram R., Doll, Ronald J., Xiao, Yushi, Esposite, Sara, Hruza, Alan, Belanger, David B., Voss, Matthew, Rainka, Matthew P., Basso, Andrea, Liu, Ming, Liang, Lianzhu, Sui, Ning, Prelusky, Daniel, Rindgen, Diane, Zhang, Likang

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Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia von Yang, Shu-Wei, Smotryski, Jennifer, McElroy, William T., Tan, Zheng, Ho, Ginny, Tulshian, Deen, Greenlee, William J., Guzzi, Mario, Zhang, Xiaoping, Mullins, Deborra, Xiao, Li, Hruza, Alan, Chan, Tze-Ming, Rindgen, Diane, Bleickardt, Carina, Hodgson, Robert

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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor von Mandal, Mihirbaran, Tan, Zheng, Madsen-Duggan, Christina, Buevich, Alexei V, Caldwell, John P, Dejesus, Reynalda, Flattery, Amy, Garlisi, Charles G, Gill, Charles, Ha, Sookhee Nicole, Ho, Ginny, Koseoglu, Sandra, Labroli, Marc, Basu, Kallol, Lee, Sang Ho, Liang, Lianzhu, Liu, Jenny, Mayhood, Todd, McGuinness, Debra, McLaren, David G, Wen, Xiujuan, Parmee, Emma, Rindgen, Diane, Roemer, Terry, Sheth, Payal, Tawa, Paul, Tata, James, Yang, Christine, Yang, Shu-Wei, Xiao, Li, Wang, Hao, Tan, Christopher, Tang, Haifeng, Walsh, Paul, Walsh, Erika, Wu, Jin, Su, Jing

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Discovery of pyrrolo-benzo-1,4-diazines as potent Nav1.7 sodium channel blockers von Ho, Ginny D., Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Heap, Charles R., Earley, William G., Courneya, Brandy, Jason Herr, R., Zhou, Xiaoping, Bridal, Terry, Rindgen, Diane, Sorota, Steve, Yang, Shu-Wei

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Bioavailable pyrrolo-benzo-1,4-diazines as Nav1.7 sodium channel blockers for the treatment of pain von Yang, Shu-Wei, Ho, Ginny D., Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Sun, Xianfeng, Sakwa, Samuel A., Herr, R. Jason, Zhou, Xiaoping, Bridal, Terry, Urban, Mark, Vivian, Jeffrey, Rindgen, Diane, Sorota, Steve

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Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain von Yang, Shu-Wei, Ho, Ginny D, Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Sun, Xianfeng, Sakwa, Samuel A, Herr, R Jason, Zhou, Xiaoping, Bridal, Terry, Urban, Mark, Vivian, Jeffrey, Rindgen, Diane, Sorota, Steve

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The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia von Ho, Ginny D., Yang, Shu-Wei, Smotryski, Jennifer, Bercovici, Ana, Nechuta, Terry, Smith, Elizabeth M., McElroy, William, Tan, Zheng, Tulshian, Deen, McKittrick, Brian, Greenlee, William J., Hruza, Alan, Xiao, Li, Rindgen, Diane, Mullins, Deborra, Guzzi, Mario, Zhang, Xiaoping, Bleickardt, Carina, Hodgson, Robert

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The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia von Ho, Ginny D., Michael Seganish, W., Bercovici, Ana, Tulshian, Deen, Greenlee, William J., Van Rijn, Rachel, Hruza, Alan, Xiao, Li, Rindgen, Diane, Mullins, Deborra, Guzzi, Mario, Zhang, Xiaoping, Bleickardt, Carina, Hodgson, Robert

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Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers von Ho, Ginny D, Tulshian, Deen, Bercovici, Ana, Tan, Zheng, Hanisak, Jennifer, Brumfield, Stephanie, Matasi, Julius, Heap, Charles R, Earley, William G, Courneya, Brandy, Herr, R Jason, Zhou, Xiaoping, Bridal, Terry, Rindgen, Diane, Sorota, Steve, Yang, Shu-Wei

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