A structure–reactivity relationship driven approach to the identification of a color test protocol for the presumptive indication of synthetic cannabimimetic drugs of abuse von Isaacs, Richard C.A

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Analytical challenges in the confirmative identification of dipyrone as an adulterant in illicit drug samples von Isaacs, Richard C.A, Harper, Michaela M, Miller, Emily C

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P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position von Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Dorsey, Bruce D., McDonough, Colleen M., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Miller-Stein, Cynthia, Michener, Maria T., Wallace, Audrey A., White, Rebecca B., Wong, Bradley K.

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Total Synthesis of Baccatin III and Taxol von Danishefsky, Samuel J, Masters, John J, Young, Wendy B, Link, J. T, Snyder, Lawrence B, Magee, Thomas V, Jung, David K, Isaacs, Richard C. A, Bornmann, William G, Alaimo, Cheryl A, Coburn, Craig A, Di Grandi, Martin J

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Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors von Isaacs, Richard C.A., Newton, Christina L., Cutrona, Kellie J., Mercer, Swati P., Payne, Linda S., Stauffer, Kenneth J., Williams, Peter D., Cook, Jacquelynn J., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., McMasters, Daniel R., Naylor-Olsen, Adel M., Michener, Maria T., Wallace, Audrey A.

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles von Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., McMasters, Daniel R., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Kuo, Lawrence C., Yan, Youwei, Lynch, J.J., Lyle, E.A.

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The Total Synthesis of a Natural Cardenolide:  (+)-Digitoxigenin von Stork, Gilbert, West, Fred, Lee, Hee Yoon, Isaacs, Richard C. A, Manabe, Shino

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Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing... von Burgey, Christopher S., Robinson, Kyle A., Lyle, Terry A., Nantermet, Philippe G., Selnick, Harold G., Isaacs, Richard C.A., Lewis, S.Dale, Lucas, Bobby J., Krueger, Julie A., Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B., Wong, Bradley, Lyle, Elizabeth A., Stranieri, Maria T., Cook, Jacquelynn J., McMasters, Daniel R., Pellicore, Janetta M., Pal, Swati, Wallace, Audrey A., Clayton, Franklin C., Bohn, Dennis, Welsh, Denise C., Lynch, Joseph J., Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J., Shafer, Jules A., Vacca, Joseph P.

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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles von Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J.

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Synthesis of an enantiomerically pure intermediate containing the CD substructure of taxol von Isaacs, Richard C. A, Di Grandi, Martin J, Danishefsky, Samuel J

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C6 Modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption von Isaacs, Richard C.A., Cutrona, Kellie J., Newton, Christina L., Sanderson, Philip E.J., Solinsky, Mark G., Baskin, Elizabeth P., Chen, I-Wu, Cooper, Carolyn M., Cook, Jacquelynn J., Gardell, Stephen J., Lewis, S.Dale, Lucas, Robert J., Lyle, Elizabeth A., Lynch, Joseph J., Naylor-Olsen, Adel M., Stranieri, Maria T., Vastag, Kari, Vacca, Joseph P.

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A straightforward route to functionalized intermediates containing the CD substructure of taxol von Magee, Thomas V, Bornmann, William G, Isaacs, Richard C. A, Danishefsky, Samuel J

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Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN von Coburn, Craig A., Young, Mary Beth, Hungate, Randall W., Isaacs, Richard C.A., Vacca, Joseph P., Huff, Joel R.

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Degradative routes to electrophilic CD-substructures of taxol von Di Grandi, Martin J, Coburn, Craig A, Isaacs, Richard C. A, Danishefsky, Samuel J

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Aromatic P 1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN von Coburn, Craig A., Young, Mary Beth, Hungate, Randall W., Isaacs, Richard C.A., Vacca, Joseph P., Huff, Joel R.

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HIV INTEGRASE INHIBITORS von PAYNE LINDA S, ISAACS RICHARD C.A, VACCA JOSEPH P

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Potassium channel inhibitors von TROTTER, B. WESLEY, WU, ZHICAI, ISAACS, RICHARD C.A, GREEN, AHREN IVER, HOFFMAN, JACOB M, BILODEAU, MARK T

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BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS von VENKATRAMAN, SHANKAR, ISAACS, RICHARD C.A, THOMPSON, WAYNE, SU, DAI-SHI, EMBREY, MARK, W, WAI, JOHN, S, LOUGHRAN, H. MARIE, KIM, BOYOUNG, WILLIAMS, PETER, D, LIM, JOHN

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HIV INTEGRASE INHIBITORS von FISHER, THORSTEN, E, PAYNE, LINDA S, ISAACS, RICHARD C.A, WAI, JOHN S

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BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS von SU DAI-SHI, LIM JOHN, WAI JOHN S, LOUGHRAN H. MARIE, KIM BOYOUNG, WILLIAMS PETER D, VENKATRAMAN SHANKAR, THOMPSON WAYNE, ISAACS RICHARD C.A, EMBREY MARK W

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