Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973) von Rice, Kenneth D, Aay, Naing, Anand, Neel K, Blazey, Charles M, Bowles, Owen J, Bussenius, Joerg, Costanzo, Simona, Curtis, Jeffry K, Defina, Steven C, Dubenko, Larisa, Engst, Stefan, Joshi, Anagha A, Kennedy, Abigail R, Kim, Angie I, Koltun, Elena S, Lougheed, Julie C, Manalo, Jean-Claire L, Martini, Jean-Francois, Nuss, John M, Peto, Csaba J, Tsang, Tsze H, Yu, Peiwen, Johnston, Stuart

Volltext

Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90 von Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.

Volltext

Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst von Gangloff, Anthony R, Litvak, Joane, Shelton, Emma J, Sperandio, David, Wang, Vivian R, Rice, Kenneth D

Volltext

The First Formal Asymmetric Synthesis of Phorbol von Wender, Paul A, Rice, Kenneth D, Schnute, Mark E

Volltext

Pyrazolopyrimidines as dual Akt/p70S6K inhibitors von Rice, Kenneth D., Kim, Moon H., Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Canne-Bannen, Lynne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Klein, Rhett R., Laird, A.Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei

Volltext

Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors von Bussenius, Joerg, Anand, Neel K., Blazey, Charles M., Bowles, Owen J., Bannen, Lynne Canne, Chan, Diva S.-M., Chen, Baili, Co, Erick W., Costanzo, Simona, DeFina, Steven C., Dubenko, Larisa, Engst, Stefan, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard G., Kim, Moon H., Klein, Rhett R., Laird, Douglas, Le, Donna T., Mac, Morrison B., Matthews, David J., Markby, David, Miller, Nicole, Nuss, John M., Parks, Jason J., Tsang, Tsze H., Tsuhako, Amy L., Wang, Yong, Xu, Wei, Rice, Kenneth D.

Volltext

An improved synthesis of 1,2,4-oxadiazoles on solid support von Rice, Kenneth D., Nuss, John M.

Volltext

High-Throughput Screening of Enzyme Inhibitors: Automatic Determination of Tight-Binding Inhibition Constants von Kuzmič, Petr, Sideris, Steve, Cregar, Lynne M., Elrod, Kyle C., Rice, Kenneth D., Janc, James W.

Volltext

Dibasic inhibitors of human mast cell tryptase. Part 2: Structure–activity relationships and requirements for potent activity von Rice, Kenneth D, Wang, Vivian R, Gangloff, Anthony R, Kuo, Elaine Y.-L, Dener, Jeffrey M, Newcomb, William S, Young, Wendy B, Putnam, Daun, Cregar, Lynne, Wong, Martin, Simpson, Paul J

Volltext

Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors von Rice, Kenneth D, Gangloff, Anthony R, Kuo, Elaine Y.-L, Dener, Jeffrey M, Wang, Vivian R, Lum, Robert, Newcomb, William S, Havel, Chris, Putnam, Daun, Cregar, Lynne, Wong, Martin, Warne, Robert L

Volltext

Dibasic Inhibitors of Human Mast Cell Tryptase. Part 3: Identification of a Series of Potent and Selective Inhibitors Containing the Benzamidine Functionality von Dener, Jeffrey M., Rice, Kenneth D., Newcomb, William S., Wang, Vivian R., Young, Wendy B., Gangloff, Anthony R., Kuo, Elaine Y.-L., Cregar, Lynne, Putnam, Daun, Wong, Martin

Volltext

Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors von Dener, Jeffrey M, Wang, Vivian R, Rice, Kenneth D, Gangloff, Anthony R, Kuo, Elaine Y.-L, Newcomb, William S, Putnam, Daun, Wong, Martin

Volltext

Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their use and Manufacture von RICE KENNETH D

Volltext bestellen

BENZOXAPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE von RICE KENNETH D

Volltext bestellen

BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE von RICE KENNETH D

Volltext bestellen

Large Hiatal Hernia Mimicking Left Atrial Mass von Chan, Jonathan, MD, Manning, Warren J., MD, Appelbaum, Evan, MD, Smith, Philip, RDCS, Rice, Kenneth, MD

Volltext

BENZOXAZEPINES ASN INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE von RICE KENNETH D

Volltext bestellen

BENZOXAZEPINES AS INHIBITORS OF P13K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE von RICE KENNETH D

Volltext bestellen

Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their use and Manufacture von RICE KENNETH D

Volltext bestellen

Benzoxazepines as Inhibitors of PI3K/M TOR and Methods of Their Use and Manufacture von RICE KENNETH D

Volltext bestellen