A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products von Baltazar, Maria T, Cable, Sophie, Carmichael, Paul L, Cubberley, Richard, Cull, Tom, Delagrange, Mona, Dent, Matthew P, Hatherell, Sarah, Houghton, Jade, Kukic, Predrag, Li, Hequn, Lee, Mi-Young, Malcomber, Sophie, Middleton, Alistair M, Moxon, Thomas E, Nathanail, Alexis V, Nicol, Beate, Pendlington, Ruth, Reynolds, Georgia, Reynolds, Joe, White, Andrew, Westmoreland, Carl

Volltext

Cell adhesion molecule CD44 is dispensable for reactive astrocyte activation during prion disease von Bradford, Barry M., Walmsley-Rowe, Lauryn, Reynolds, Joe, Verity, Nicholas, Mabbott, Neil A.

Volltext

Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing von Rajagopal, Ramya, Baltazar, Maria T, Carmichael, Paul L, Dent, Matthew P, Head, Julia, Li, Hequn, Muller, Iris, Reynolds, Joe, Sadh, Kritika, Simpson, Wendy, Spriggs, Sandrine, White, Andrew, Kukic, Predrag

Volltext

PBK modelling of topical application and characterisation of the uncertainty of C max estimate: A case study approach von Li, Hequn, Reynolds, Joe, Sorrell, Ian, Sheffield, David, Pendlington, Ruth, Cubberley, Richard, Nicol, Beate

Volltext

PBK modelling of topical application and characterisation of the uncertainty of Cmax estimate: A case study approach von Li, Hequn, Reynolds, Joe, Sorrell, Ian, Sheffield, David, Pendlington, Ruth, Cubberley, Richard, Nicol, Beate

Volltext

A proof-of-concept multi-tiered Bayesian approach for the integration of physiochemical properties and toxicokinetic time-course data for Daphnia magna von Collins, Jacob-Joe, Reynolds, Joe, Campos, Bruno, Engi, Patrik, Rivetti, Claudia, Pietrenko, Tymoteusz, Viant, Mark R., Fitton, George

Volltext

Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment von Hatherell, Sarah, Baltazar, Maria T, Reynolds, Joe, Carmichael, Paul L, Dent, Matthew, Li, Hequn, Ryder, Stephanie, White, Andrew, Walker, Paul, Middleton, Alistair M

Volltext

Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow von Middleton, Alistair M, Reynolds, Joe, Cable, Sophie, Baltazar, Maria Teresa, Li, Hequn, Bevan, Samantha, Carmichael, Paul L, Dent, Matthew Philip, Hatherell, Sarah, Houghton, Jade, Kukic, Predrag, Liddell, Mark, Malcomber, Sophie, Nicol, Beate, Park, Benjamin, Patel, Hiral, Scott, Sharon, Sparham, Chris, Walker, Paul, White, Andrew

Volltext

Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data von Basili, Danilo, Reynolds, Joe, Houghton, Jade, Malcomber, Sophie, Chambers, Bryant, Liddell, Mark, Muller, Iris, White, Andrew, Shah, Imran, Everett, Logan J, Middleton, Alistair, Bender, Andreas

Volltext

A Bayesian approach for inferring global points of departure from transcriptomics data von Reynolds, Joe, Malcomber, Sophie, White, Andrew

Volltext

Next generation risk assessment for occupational chemical safety – A real world example with sodium-2-hydroxyethane sulfonate von Wood, Adam, Breffa, Catherine, Chaine, Caroline, Cubberley, Richard, Dent, Matthew, Eichhorn, Joachim, Fayyaz, Susann, Grimm, Fabian A., Houghton, Jade, Kiwamoto, Reiko, Kukic, Predrag, Lee, MoungSook, Malcomber, Sophie, Martin, Suzanne, Nicol, Beate, Reynolds, Joe, Riley, Gordon, Scott, Sharon, Smith, Colin, Westmoreland, Carl, Wieland, Willemien, Williams, Mesha, Wolton, Kathryn, Zellmann, Tristan, Gutsell, Steve

Volltext

Probabilistic prediction of human skin sensitiser potency for use in next generation risk assessment von Reynolds, Joe, MacKay, Cameron, Gilmour, Nicola, Miguel-Vilumbrales, David, Maxwell, Gavin

Volltext

Abstract LB-061: HER2-targeted PEGylated liposomal doxorubicin (MM-302) efficiently targets the HER2 intermediate cell population in vitro and in vivo von Geretti, Elena, Espelin, Christopher, Adiwijaya, Bambang, Dumont, Nancy, Coma, Silvia, Koncki, Zachary, Pham, Minh, Garcia, Gabriela, Bloom, Troy, Rimkunas, Victoria, Reynolds, Joe, Campbell, Karen, Moyo, Victor, Molnar, Istvan, LoRusso, Patricia, Krop, Ian, Miller, Kathy, Ma, Cynthia, Munster, Pamela, Wickham, Thomas

Volltext

Abstract P4-15-04: Effect of pre-treatment with cyclophosphamide on MM-302 (HER2-targeted liposomal doxorubicin) deposition in HER2-positive metastatic breast cancer patients asses... von Miller, Kathy, LoRusso, Patricia M, Munster, Pamela, Krop, Ian, Ma, Cynthia, Lee, Helen, Reynolds, Joe, Campbell, Karen, Moyo, Victor, Hendriks, Bart, Wickham, Thomas, Siegel, Barry A, Shields, Anthony F

Volltext

Active and passive imaging in the THz spectral region : phenomenology, dynamic range, modes, and illumination von PETKIE, Douglas T, CASTO, Corey, REYNOLDS, Joe, O'BRIEN, Sean, TOFSTED, David, DE LUCIA, Frank C, MURRILL, Steven R, REDMAN, Brian, ESPINOLA, Richard L, FRANCK, Charmaine C, JACOBS, Eddie L, GRIFFIN, Steven T, HALFORD, Carl E

Volltext

A phase I study of MM-302, a HER2-targeted liposomal doxorubicin, in patients with advanced, HER2-positive (HER2+) breast cancer von Munster, Pamela N., Miller, Kathy, Krop, Ian E., Dhindsa, Navreet, Reynolds, Joe, Geretti, Elena, Niyikiza, Clet, Nielsen, Ulrik, Hendriks, Bart, Wickham, Thomas J., Moyo, Victor M., LoRusso, Patricia

Volltext

Abstract 3637: MM-302, a HER2-targeted liposomal doxorubicin, shows binding/uptake and efficacy in HER2 2+ cells and xenograft models von Klinz, Stephan, Eckelhofer, Isabelle, Gaddy, Daniel, Geretti, Elena, Hendriks, Bart, Lee, Helen, Leonard, Shannon, Reynolds, Joe, Wickham, Tom

Volltext

Abstract 4915: Physiologically-based PK modeling of liposomal drug delivery points to a key role of tumor deposition in determining the relative efficacy of liposomal vs. free doxo... von Hendriks, Bart, Reynolds, Joe, Klinz, Stephan, Leonard, Shannon, Geretti, Elena, Lee, Helen, Eckelhofer, Isabelle, Gaddy, Daniel, Wickham, Thomas

Volltext

Abstract C90: HER2-targeted liposomal doxorubicin MM-302 has a favorable cardiosafety profile in preclinical models von Geretti, Elena, Reynolds, Joe, Hendriks, Bart, Eckelhofer, Isabelle, Espelin, Chris, Gaddy, Daniel, Klinz, Stephan, Lee, Helen, Leonard, Shannon, Olivier, Ken, Agresta, Sam, Niyikiza, Clet, Nielsen, Ulrik, Wickham, Thomas

Volltext

Servant-Leadership, Feminism, and Gender Well-Being: How Leaders Transcend Global Inequities Through Hope, Unity, and Love von Song, Jiying, Walsh, Joe, Reynolds, Kae, Tilghman-Havens, Jennifer, Ferch, Shann Ray, Spears, Larry C

Volltext