BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment von Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.

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Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo von Jeong, Mira, Park, Hyun Jung, Celik, Hamza, Ostrander, Elizabeth L., Reyes, Jaime M., Guzman, Anna, Rodriguez, Benjamin, Lei, Yong, Lee, Yeojin, Ding, Lei, Guryanova, Olga A., Li, Wei, Goodell, Margaret A., Challen, Grant A.

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BET bromodomain proteins regulate enhancer function during adipogenesis von Brown, Jonathan D., Feldman, Zachary B., Doherty, Sean P., Reyes, Jaime M., Rahl, Peter B., Lin, Charles Y., Sheng, Quanhu, Duan, Qiong, Federation, Alexander J., Kung, Andrew L., Haldar, Saptarsi M., Young, Richard A., Plutzky, Jorge, Bradner, James E.

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Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome von Tovy, Ayala, Rosas, Carina, Gaikwad, Amos S, Medrano, Geraldo, Zhang, Linda, Reyes, Jaime M, Huang, Yung-Hsin, Arakawa, Tastuhiko, Kurtz, Kristen, Conneely, Shannon E, Guzman, Anna G, Aguilar, Rogelio, Gao, Anne, Chen, Chun-Wei, Kim, Jean J, Carter, Melissa T, Lasa-Aranzasti, Amaia, Valenzuela, Irene, Van Maldergem, Lionel, Brunetti, Lorenzo, Hicks, M John, Marcogliese, Andrea N, Goodell, Margaret A, Rau, Rachel E

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Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression von Mowery, Cody T., Reyes, Jaime M., Cabal-Hierro, Lucia, Higby, Kelly J., Karlin, Kristen L., Wang, Jarey H., Kimmerling, Robert J., Cejas, Paloma, Lim, Klothilda, Li, Hubo, Furusawa, Takashi, Long, Henry W., Pellman, David, Chapuy, Bjoern, Bustin, Michael, Manalis, Scott R., Westbrook, Thomas F., Lin, Charles Y., Lane, Andrew A.

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Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis von Tovy, Ayala, Reyes, Jaime M, Zhang, Linda, Huang, Yung-Hsin, Rosas, Carina, Daquinag, Alexes C, Guzman, Anna, Ramabadran, Raghav, Chen, Chun-Wei, Gu, Tianpeng, Gupta, Sinjini, Ortinau, Laura, Park, Dongsu, Cox, Aaron R, Rau, Rachel E, Hartig, Sean M, Kolonin, Mikhail G, Goodell, Margaret A

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Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape von Nabet, Behnam, Ó Broin, Pilib, Reyes, Jaime M., Shieh, Kevin, Lin, Charles Y., Will, Christine M., Popovic, Relja, Ezponda, Teresa, Bradner, James E., Golden, Aaron A., Licht, Jonathan D.

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Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation von Reyes, Jaime M., Tovy, Ayala, Zhang, Linda, Bortoletto, Angelina S., Rosas, Carina, Chen, Chun-Wei, Waldvogel, Sarah M., Guzman, Anna G., Aguilar, Rogelio, Gupta, Sinjini, Liu, Ling, Buckley, Matthew T., Patel, Kalyani R., Marcogliese, Andrea N., Li, Yumei, Curry, Choladda V., Rando, Thomas A., Brunet, Anne, Parchem, Ronald J., Rau, Rachel E., Goodell, Margaret A.

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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands von Gechijian, Lara N., Buckley, Dennis L., Lawlor, Matthew A., Reyes, Jaime M., Paulk, Joshiawa, Ott, Christopher J., Winter, Georg E., Erb, Michael A., Scott, Thomas G., Xu, Mousheng, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Kwiatkowski, Nicholas P., Perry, Jennifer A., Qi, Jun, Gray, Nathanael S., Bradner, James E.

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Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma von Zeid, Rhamy, Lawlor, Matthew A., Poon, Evon, Reyes, Jaime M., Fulciniti, Mariateresa, Lopez, Michael A., Scott, Thomas G., Nabet, Behnam, Erb, Michael A., Winter, Georg E., Jacobson, Zoe, Polaski, Donald R., Karlin, Kristen L., Hirsch, Rachel A., Munshi, Nikhil P., Westbrook, Thomas F., Chesler, Louis, Lin, Charles Y., Bradner, James E.

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Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging von Liu, Ling, Kim, Soochi, Buckley, Matthew T., Reyes, Jaime M., Kang, Jengmin, Tian, Lei, Wang, Mingqiang, Lieu, Alexander, Mao, Michelle, Rodriguez-Mateo, Cristina, Ishak, Heather D., Jeong, Mira, Wu, Joseph C., Goodell, Margaret A., Brunet, Anne, Rando, Thomas A.

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High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program von Labbé, David P., Zadra, Giorgia, Yang, Meng, Reyes, Jaime M., Lin, Charles Y., Cacciatore, Stefano, Ebot, Ericka M., Creech, Amanda L., Giunchi, Francesca, Fiorentino, Michelangelo, Elfandy, Habiba, Syamala, Sudeepa, Karoly, Edward D., Alshalalfa, Mohammed, Erho, Nicholas, Ross, Ashley, Schaeffer, Edward M., Gibb, Ewan A., Takhar, Mandeep, Den, Robert B., Lehrer, Jonathan, Karnes, R. Jeffrey, Freedland, Stephen J., Davicioni, Elai, Spratt, Daniel E., Ellis, Leigh, Jaffe, Jacob D., DʼAmico, Anthony V., Kantoff, Philip W., Bradner, James E., Mucci, Lorelei A., Chavarro, Jorge E., Loda, Massimo, Brown, Myles

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Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain von Buckley, Matthew T, Sun, Eric D, George, Benson M, Liu, Ling, Schaum, Nicholas, Xu, Lucy, Reyes, Jaime M, Goodell, Margaret A, Weissman, Irving L, Wyss-Coray, Tony, Rando, Thomas A, Brunet, Anne

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Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor von Huang, Yung-Hsin, Chen, Chun-Wei, Sundaramurthy, Venkatasubramaniam, Słabicki, Mikołaj, Hao, Dapeng, Watson, Caroline J, Tovy, Ayala, Reyes, Jaime M, Dakhova, Olga, Crovetti, Brielle R, Galonska, Christina, Lee, Minjung, Brunetti, Lorenzo, Zhou, Yubin, Tatton-Brown, Katrina, Huang, Yun, Cheng, Xiaodong, Meissner, Alexander, Valk, Peter J M, Van Maldergem, Lionel, Sanders, Mathijs A, Blundell, Jamie R, Li, Wei, Ebert, Benjamin L, Goodell, Margaret A

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DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells von Ramabadran, Raghav, Wang, Jarey H., Reyes, Jaime M., Guzman, Anna G., Gupta, Sinjini, Rosas, Carina, Brunetti, Lorenzo, Gundry, Michael C., Tovy, Ayala, Long, Hali, Gu, Tianpeng, Cullen, Sean M., Tyagi, Siddhartha, Rux, Danielle, Kim, Jean J., Kornblau, Steven M., Kyba, Michael, Stossi, Fabio, Rau, Rachel E., Takahashi, Koichi, Westbrook, Thomas F., Goodell, Margaret A.

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SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation von Chen, Chun-Wei, Zhang, Linda, Dutta, Ravi, Niroula, Abhishek, Miller, Peter G, Gibson, Christopher J, Bick, Alexander G, Reyes, Jaime M, Lee, Yi-Tang, Tovy, Ayala, Gu, Tianpeng, Waldvogel, Sarah, Chen, Yi-Hung, Venters, Bryan J, Estève, Pierre-Olivier, Pradhan, Sriharsa, Keogh, Michael-Christopher, Natarajan, Pradeep, Takahashi, Koichi, Sperling, Adam S, Goodell, Margaret A

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Dose-dependent effects of Dnmt3a in an inducible murine model of KrasG12D-driven leukemia von Rogers, Jason H., Rosen, Allison, Reyes, Jaime M., Ketkar, Shamika, Conneely, Shannon E., Gupta, Rohit, Yang, Luibin, Miller, Matthew B., Medrano, Geraldo, Aguilar, Rogelio, Uchendu, Nneka, Goodell, Margaret A., Rau, Rachel E.

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Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer von Zhang, Haikuo, Qi, Jun, Reyes, Jaime M, Li, Lewyn, Rao, Prakash K, Li, Fugen, Lin, Charles Y, Perry, Jennifer A, Lawlor, Matthew A, Federation, Alexander, De Raedt, Thomas, Li, Yvonne Y, Liu, Yan, Duarte, Melissa A, Zhang, Yanxi, Herter-Sprie, Grit S, Kikuchi, Eiki, Carretero, Julian, Perou, Charles M, Reibel, Jacob B, Paulk, Joshiawa, Bronson, Roderick T, Watanabe, Hideo, Brainson, Christine Fillmore, Kim, Carla F, Hammerman, Peter S, Brown, Myles, Cichowski, Karen, Long, Henry, Bradner, James E, Wong, Kwok-Kin

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SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation von Chen, Chun-Wei, Zhang, Linda, Dutta, Ravi, Niroula, Abhishek, Miller, Peter G, Gibson, Christopher J, Bick, Alexander G, Reyes, Jaime M, Lee, Yi-Tang, Tovy, Ayala, Gu, Tianpeng, Waldvogel, Sarah, Chen, Yi-Hung, Venters, Bryan J, Estève, Pierre-Olivier, Pradhan, Sriharsa, Keogh, Michael-Christopher, Natarajan, Pradeep, Takahashi, Koichi, Sperling, Adam S, Goodell, Margaret A

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Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice von Sportoletti, Paolo, Sorcini, Daniele, Guzman, Anna G., Reyes, Jaime M., Stella, Arianna, Marra, Andrea, Sartori, Sara, Brunetti, Lorenzo, Rossi, Roberta, Papa, Beatrice Del, Adamo, Francesco Maria, Pianigiani, Giulia, Betti, Camilla, Scialdone, Annarita, Guarente, Valerio, Spinozzi, Giulio, Tini, Valentina, Martelli, Maria Paola, Goodell, Margaret A., Falini, Brunangelo

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