Structure-Based Design and Evaluation of Naphthalene Diimide G‑Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells von Micco, Marialuisa, Collie, Gavin W, Dale, Aaron G, Ohnmacht, Stephan A, Pazitna, Ingrida, Gunaratnam, Mekala, Reszka, Anthony P, Neidle, Stephen

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Structural Basis of DNA Quadruplex Recognition by an Acridine Drug von Campbell, Nancy H, Parkinson, Gary N, Reszka, Anthony P, Neidle, Stephen

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A G-Rich Sequence within the c-kit Oncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics von Hsu, Shang-Te Danny, Varnai, Peter, Bugaut, Anthony, Reszka, Anthony P, Neidle, Stephen, Balasubramanian, Shankar

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Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation von Wei, Dengguo, Parkinson, Gary N, Reszka, Anthony P, Neidle, Stephen

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A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene von Fernando, Himesh, Reszka, Anthony P, Huppert, Julian, Ladame, Sylvain, Rankin, Sarah, Venkitaraman, Ashok R, Neidle, Stephen, Balasubramanian, Shankar

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A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line von Gunaratnam, Mekala, Collie, Gavin W., Reszka, Anthony P., Todd, Alan K., Parkinson, Gary N., Neidle, Stephen

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Putative DNA Quadruplex Formation within the Human c-kit Oncogene von Rankin, Sarah, Reszka, Anthony P, Huppert, Julian, Zloh, Mire, Parkinson, Gary N, Todd, Alan K, Ladame, Sylvain, Balasubramanian, Shankar, Neidle, Stephen

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The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function von Burger, Angelika M, Dai, Fangping, Schultes, Christoph M, Reszka, Anthony P, Moore, Michael J, Double, John A, Neidle, Stephen

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TRAP–LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules von Reed, Julie, Gunaratnam, Mekala, Beltran, Monica, Reszka, Anthony P, Vilar, Ramon, Neidle, Stephen

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Mechanism of acridine-based telomerase inhibition and telomere shortening von Gunaratnam, Mekala, Greciano, Olga, Martins, Cristina, Reszka, Anthony P., Schultes, Christoph M., Morjani, Hamid, Riou, Jean-Francois, Neidle, Stephen

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Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule von Gunaratnam, Mekala, Swank, Stephen, Haider, Shozeb M, Galesa, Katja, Reszka, Anthony P, Beltran, Monica, Cuenca, Francisco, Fletcher, Jonathan A, Neidle, Stephen

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Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and charge von White, Elizabeth W., Tanious, Farial, Ismail, Mohamed A., Reszka, Anthony P., Neidle, Stephen, Boykin, David W., Wilson, W. David

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Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes von Collie, Gavin, Reszka, Anthony P, Haider, Shozeb M, Gabelica, Valérie, Parkinson, Gary N, Neidle, Stephen

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Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA von Campbell, Nancy H, Smith, Daniel L, Reszka, Anthony P, Neidle, Stephen, O'Hagan, David

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Targeting pancreatic cancer with a G-quadruplex ligand von Gunaratnam, Mekala, Fuente, Maria de la, Hampel, Sonja M., Todd, Alan K., Reszka, Anthony P., Schätzlein, Andreas, Neidle, Stephen

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Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands von Hampel, Sonja M., Pepe, Antonella, Greulich-Bode, Karin M., Malhotra, Sanjay V., Reszka, Anthony P., Veith, Sebastian, Boukamp, Petra, Neidle, Stephen

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Rational Design of Substituted Diarylureas: A Scaffold for Binding to G-Quadruplex Motifs von Drewe, William C, Nanjunda, Rupesh, Gunaratnam, Mekala, Beltran, Monica, Parkinson, Gary N, Reszka, Anthony P, Wilson, W. David, Neidle, Stephen

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Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries von Rahman, Khondaker M., Tizkova, Karolina, Reszka, Anthony P., Neidle, Stephen, Thurston, David E.

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Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors von Harrison, R. John, Cuesta, Javier, Chessari, Gianni, Read, Martin A, Basra, Sanji K, Reszka, Anthony P, Morrell, James, Gowan, Sharon M, Incles, Christopher M, Tanious, Farial A, Wilson, W. David, Kelland, Lloyd R, Neidle, Stephen

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C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: Anticancer profile and G-quadruplex stabilization von Lavrado, João, Reszka, Anthony P., Moreira, Rui, Neidle, Stephen, Paulo, Alexandra

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