DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells von Bruyer, Angelique, Maes, Ken, Herviou, Laurie, Kassambara, Alboukadel, Seckinger, Anja, Cartron, Guillaume, Rème, Thierry, Robert, Nicolas, Requirand, Guilhem, Boireau, Stéphanie, Müller-Tidow, Carsten, Veyrune, Jean-luc, Vincent, Laure, Bouhya, Salahedine, Goldschmidt, Hartmut, Vanderkerken, Karin, Hose, Dirk, Klein, Bernard, De Bruyne, Elke, Moreaux, Jerome

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The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance von Ovejero, Sara, Viziteu, Elena, Dutrieux, Laure, Devin, Julie, Lin, Yea-Lih, Alaterre, Elina, Jourdan, Michel, Basbous, Jihane, Requirand, Guilhem, Robert, Nicolas, de Boussac, Hugues, Seckinger, Anja, Hose, Dirk, Vincent, Laure, Herbaux, Charles, Constantinou, Angelos, Pasero, Philippe, Moreaux, Jérôme

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Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma von Bruyer, Angélique, Dutrieux, Laure, de Boussac, Hugues, Martin, Thibaut, Chemlal, Djamila, Robert, Nicolas, Requirand, Guilhem, Cartron, Guillaume, Vincent, Laure, Herbaux, Charles, Lutzmann, Malik, Bret, Caroline, Pasero, Philippe, Moreaux, Jérôme, Ovejero, Sara

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Development of gene expression-based score to predict sensitivity of multiple myeloma cells to DNA methylation inhibitors von Moreaux, Jérôme, Rème, Thierry, Leonard, Wim, Veyrune, Jean-Luc, Requirand, Guilhem, Goldschmidt, Hartmut, Hose, Dirk, Klein, Bernard

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Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration von Moreaux, Jerome, Hose, Dirk, Kassambara, Alboukadel, Reme, Thierry, Moine, Philippe, Requirand, Guilhem, Goldschmidt, Hartmut, Klein, Bernard

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PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs von Herviou, Laurie, Kassambara, Alboukadel, Boireau, Stéphanie, Robert, Nicolas, Requirand, Guilhem, Müller-Tidow, Carsten, Vincent, Laure, Seckinger, Anja, Goldschmidt, Hartmut, Cartron, Guillaume, Hose, Dirk, Cavalli, Giacomo, Moreaux, Jerome

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Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays von DE VOS, John, THYKJAER, Thomas, ROSSI, Jean-Francois, ØRNTOFT, Torben, KLEIN, Bernard, TARTE, Karin, ENSSLEN, Matthias, RAYNAUD, Pierre, REQUIRAND, Guilhem, PELLET, Florence, PANTESCO, Véronique, REME, Thierry, JOURDAN, Michel

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Integrative Multi-Omics Analysis of Tumor-Immune Microenvironment in Multiple Myeloma: Novel Insights and Therapeutic Implications von Alaterre, Elina, Robert, Nicolas, Requirand, Guilhem, Machura, Amélie, De Boussac, Hugues, Vincent, Laure, Herbaux, Charles, Bruyer, Angélique, Moreaux, Jerome

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Characterization of a New Metabolic Score Correlated with CD38 Cell-Surface Expression and Response to Daratumumab Treatment in Multiple Myeloma von Steer, Alizée, Alaterre, Elina, Chamlal, Djamila, Varlet, Emmanuel, Machura, Amélie, Kassambara, Alboukadel, Requirand, Guilhem, Robert, Nicolas, Vincent, Laure, Herbaux, Charles, De Boussac, Hugues, Bruyer, Angélique, Moreaux, Jerome

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Translation Inhibition through eIF4A1 Targeting in Multiple Myeloma Is a Promising Therapeutic Strategy von Dutrieux, Laure, Loughran, Elle, Choquet, Armelle, Herault, Hélène, Guillemin, Antoine, Robert, Nicolas, Requirand, Guilhem, Cartron, Guillaume, Vincent, Laure, Herbaux, Charles, Rivals, Eric, David, Alexandre, Moreaux, Jerome

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Lipid-Mediated Modulation of DNA Damage Signaling As a Prognostic and Therapeutic Strategy Against Multiple Myeloma von Garcia De Paco, Elvira, Soulet, Caroline, Requirand, Guilhem, Robert, Nicolas, Cartron, Guillaume, Vincent, Laure, Herbaux, Charles, Moriel-Carretero, Maria, Moreaux, Jerome

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EZH2 Targeting Induces CD38 Upregulation and Response to Anti-CD38 Antibodies in Multiple Myeloma von Chemlal, Djamila, Varlet, Emmanuel, Machura, Amelie, Requirand, Guilhem, Robert, Nicolas, Alaterre, Elina, Vincent, Laure, Herbaux, Charles, Cavalli, Giacomo, Bruyer, Angélique, De Boussac, Hugues, Moreaux, Jerome

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Development of a Robust BH3 Profiling Toolkit for Precision Medicine in Hematologic Malignancies von Jacquier, Valentin, Guillemin, Antoine, Ovejero-Merino, Sara, Requirand, Guilhem, Karmous-Gadacha, Ouissem, Dutrieux, Laure, Romero, Andrea, Steer, Alizée, Machura, Amelie, De Boussac, Hugues, Moreaux, Jerome, Herbaux, Charles

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EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma von Chemlal, Djamila, Varlet, Emmanuel, Machura, Amelie, Ovejero, Sara, Requirand, Guilhem, Robert, Nicolas, Cartron, Guillaume, Alaterre, Elina, Bret, Caroline, Vincent, Laure, Herbaux, Charles, Cavalli, Giacomo, Bruyer, Angélique, De Boussac, Hugues, Moreaux, Jerome

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Genomic Characterization of in Vitro Acquired-Resistance to Proteasome Inhibitors von De Boussac, Hugues, Kassambara, Alboukadel, Machura, Amelie, Chemlal, Djamila, Gourzones, Claire, Requirand, Guilhem, Robert, Nicolas, Vincent, Laure, Herbaux, Charles, Bruyer, Angélique, Moreaux, Jerome

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Exploiting Transcription-Replication Conflicts As a Novel Therapeutic Intervention in Multiple Myeloma von Dutrieux, Laure, Lin, Yea-Lih, Lutzmann, Malik, Requirand, Guilhem, Robert, Nicolas, Vincent, Laure, Cartron, Guillaume, Herbaux, Charles, Rodriguez, Raphael, Cogne, Michel, Pasero, Philippe, Moreaux, Jerome

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Extreme thrombocytosis with an aggressive evolution harboring a novel variant of calreticulin ( CALR ) in exon 3 von Bonnet, Sarah, Carillo, Serge, Legrand, Baptiste, Burroni, Barbara, Lavabre-Bertrand, Thierry, Requirand, Guilhem, Robert, Nicolas, Fornero, Lea, Al Mansoori, Ahmed, Moreaux, Jérôme, Cartron, Guillaume, Gabellier, Ludovic, Herbaux, Charles

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EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma von Chemlal, Djamila, Varlet, Emmanuel, Machura, Amelie, Ovejero, Sara, Requirand, Guilhem, Robert, Nicolas, Cartron, Guillaume, Alaterre, Elina, Bret, Caroline, Vincent, Laure, Herbaux, Charles, Cavalli, Giacomo, Bruyer, Angélique, de Boussac, Hugues, Moreaux, Jerome

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Ironomycin Induces Mantle Cell Lymphoma Cell Death By Targeting Iron Metabolism Addiction von ovejero-Merino, Sara, Alibert, Laura, Devin, Julie, Cañeque, Tatiana, Karmous Gadacha, Ouissem, Abouladze, Matthieu, Requirand, Guilhem, Robert, Nicolas, De Boussac, Hugues, Cartron, Guillaume, Herbaux, Charles, Rodriguez, Raphael, Moreaux, Jerome, Bret, Caroline

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Targeting Iron Homeostasis As a Therapeutic Strategy in Multiple Myeloma von ovejero-Merino, Sara, Devin, Julie, Cañeque, Tatiana, Alibert, Laura, Requirand, Guilhem, Robert, Nicolas, Steer, Alizée, Machura, Amelie, Hirtz, Christophe, Bruyer, Angélique, Vincent, Laure, Cartron, Guillaume, Herbaux, Charles, Rodriguez, Raphael, Bret, Caroline, Moreaux, Jerome

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