Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6 von Toogood, Peter L, Harvey, Patricia J, Repine, Joseph T, Sheehan, Derek J, VanderWel, Scott N, Zhou, Hairong, Keller, Paul R, McNamara, Dennis J, Sherry, Debra, Zhu, Tong, Brodfuehrer, Joanne, Choi, Chung, Barvian, Mark R, Fry, David W

Volltext

Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4 von VanderWel, Scott N, Harvey, Patricia J, McNamara, Dennis J, Repine, Joseph T, Keller, Paul R, Quin, John, Booth, R. John, Elliott, William L, Dobrusin, Ellen M, Fry, David W, Toogood, Peter L

Volltext

Discovery of PF-00217830: Aryl piperazine napthyridinones as D₂ partial agonists for schizophrenia and bipolar disorder von Johnson, Douglas S, Choi, Chung, Fay, Lorraine K, Favor, David A, Repine, Joseph T, White, Andrew D, Akunne, Hyacinth C, Fitzgerald, Lawrence, Nicholls, Kim, Snyder, Bradley J, Whetzel, Steven Z, Zhang, Liming, Serpa, Kevin A

Volltext

Synthesis of fluorinated 1,8-naphthyridinone derivatives von Repine, Joseph T., Johnson, Douglas S., Stuk, Timothy, White, Andrew D., Stier, Michael A., Li, Tingsheng, Yang, Zhixiang, Maiti, Samarendra N.

Volltext

Structure−Activity Relationships in a Series of Orally Active γ-Hydroxy Butenolide Endothelin Antagonists von Patt, William C, Edmunds, Jeremy J, Repine, Joseph T, Berryman, Kent A, Reisdorph, Billy R, Lee, Chet, Plummer, Mark S, Shahripour, Aurash, Haleen, Stephen J, Keiser, Joan A, Flynn, Mike A, Welch, Kathleen M, Reynolds, Elwood E, Rubin, Ron, Tobias, Brian, Hallak, Hussein, Doherty, Annette M

Volltext

Butenolide Endothelin Antagonists with Improved Aqueous Solubility von Patt, William C, Cheng, Xue-Min, Repine, Joseph T, Lee, Chet, Reisdorph, Bill R, Massa, Mark A, Doherty, Annette M, Welch, Kathleen M, Bryant, John W, Flynn, Michael A, Walker, Donnelle M, Schroeder, Richard L, Haleen, Stephen J, Keiser, Joan A

Volltext

Discovery of PF-00217830: Aryl piperazine napthyridinones as D 2 partial agonists for schizophrenia and bipolar disorder von Johnson, Douglas S., Choi, Chung, Fay, Lorraine K., Favor, David A., Repine, Joseph T., White, Andrew D., Akunne, Hyacinth C., Fitzgerald, Lawrence, Nicholls, Kim, Snyder, Bradley J., Whetzel, Steven Z., Zhang, Liming, Serpa, Kevin A.

Volltext

Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors von Lunney, Elizabeth A, Hamilton, Harriet W, Hodges, John C, Kaltenbronn, James S, Repine, Joseph T, Badasso, Mohammed, Cooper, Jon B, Dealwis, Chris, Wallace, Bonnie A

Volltext

Synthesis of monofluorinated 1-(naphthalen-1-yl)piperazines von Repine, Joseph T., Johnson, Douglas S., White, Andrew D., Favor, David A., Stier, Michael A., Yip, Judy, Rankin, Trent, Ding, Qizhu, Maiti, Samarendra N.

Volltext

Discovery of PF-00217830: Aryl piperazine napthyridinones as D sub(2 partial agonists for schizophrenia and bipolar disorder) von Johnson, Douglas S, Choi, Chung, Fay, Lorraine K, Favor, David A, Repine, Joseph T, White, Andrew D, Akunne, Hyacinth C, Fitzgerald, Lawrence, Nicholls, Kim, Snyder, Bradley J, Whetzel, Steven Z, Zhang, Liming, Serpa, Kevin A

Volltext

Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues von Repine, Joseph T, Kaltenbronn, James S, Doherty, Annette M, Hamby, James M, Himmelsbach, Richard J, Kornberg, Brian E, Taylor, Michael D, Lunney, ELizabeth A, Humblet, Christine

Volltext

New inhibitors of human renin that contain novel replacements at the P2 site von Doherty, Annette M, Kaltenbronn, James S, Hudspeth, James P, Repine, Joseph T, Roark, William H, Sircar, Ila, Tinney, Frank J, Connolly, Cleo J, Hodges, John C

Volltext

Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate von Repine, Joseph T, Himmelsbach, Richard J, Hodges, John C, Kaltenbronn, James S, Sircar, Ila, Skeean, Richard W, Brennan, Sean T, Hurley, Timothy R, Lunney, Elizabeth

Volltext

γ-Carbamate butenolide analogues as potent ET A selective endothelin receptor antagonists and prodrugs von Patt, William C., Reisdorph, Billy R., Repine, Joseph T., Doherty, Annette M., Haleen, Stephen J., Walker, Donnelle M., Welch, Kathleen M., Flynn, Michael A., Hallak, Hussein, Reyner, Eric L., Stewart, Barbra H.

Volltext

Design, synthesis and solution structure of a renin inhibitor Structural constraints from NOE, and homonuclear and heteronuclear coupling constants combined with distance geometry... von Reily, Michael D., Thanabal, Venkataraman, Lunney, Elizabeth A., Repine, Joseph T., Humblet, Christine C., Wagner, Gerhard

Volltext

γ-Carbamate butenolide analogues as potent ETA selective endothelin receptor antagonists and prodrugs von PATT, W. C, REISDORPH, B. R, STEWART, B. H, REPINE, J. T, DOHERTY, A. M, HALEEN, S. J, WALKER, D. M, WELCH, K. M, FLYNN, M. A, HALLAK, H, REYNER, E. L

Volltext

ChemInform Abstract: Synthesis of Fluorinated 1,8-Naphthyridinone Derivatives von Repine, Joseph T., Johnson, Douglas S., Stuk, Timothy, White, Andrew D., Stier, Michael A., Li, Tingsheng, Yang, Zhixiang, Maiti, Samarendra N.

Volltext

Organic synthesis von REPINE, JOSEPH T

Volltext bestellen

2-AMINOPYRIDIN-SUBSTITUIERTEHETEROCYCLEN ALS INHIBITOREN DER ZELLULÄREN PROLIFERATION von WARMUS, JOSEPH S, TOOGOOD, PETER L, MCNAMARA, DENNIS J, FLAMME, CATHLIN M, REPINE, JOSEPH T, VANDERWEL, SCOTT N

Volltext bestellen

2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION von WARMUS, JOSEPH S, TOOGOOD, PETER L, MCNAMARA, DENNIS J, FLAMME, CATHLIN M, REPINE, JOSEPH T, VANDERWEL, SCOTT N

Volltext bestellen