Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule von Tsai, Jordan C, Miller-Vedam, Lakshmi E, Anand, Aditya A, Jaishankar, Priyadarshini, Nguyen, Henry C, Renslo, Adam R, Frost, Adam, Walter, Peter

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A reactivity-based probe of the intracellular labile ferrous iron pool von Spangler, Benjamin, Morgan, Charles W, Fontaine, Shaun D, Vander Wal, Mark N, Chang, Christopher J, Wells, James A, Renslo, Adam R

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Protease inhibitors targeting coronavirus and filovirus entry von Zhou, Yanchen, Vedantham, Punitha, Lu, Kai, Agudelo, Juliet, Carrion, Ricardo, Nunneley, Jerritt W., Barnard, Dale, Pöhlmann, Stefan, McKerrow, James H., Renslo, Adam R., Simmons, Graham

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Pharmacological brake-release of mRNA translation enhances cognitive memory von Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter

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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response von Sidrauski, Carmela, Tsai, Jordan C, Kampmann, Martin, Hearn, Brian R, Vedantham, Punitha, Jaishankar, Priyadarshini, Sokabe, Masaaki, Mendez, Aaron S, Newton, Billy W, Tang, Edward L, Verschueren, Erik, Johnson, Jeffrey R, Krogan, Nevan J, Fraser, Christopher S, Weissman, Jonathan S, Renslo, Adam R, Walter, Peter

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch von Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter

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Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis von Chen, Ying-Chu, Oses-Prieto, Juan A, Pope, Lauren E, Burlingame, Alma L, Dixon, Scott J, Renslo, Adam R

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Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States von Gentile, Daniel R., Rathinaswamy, Manoj K., Jenkins, Meredith L., Moss, Steven M., Siempelkamp, Braden D., Renslo, Adam R., Burke, John E., Shokat, Kevan M.

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Cilia-Associated Oxysterols Activate Smoothened von Raleigh, David R., Sever, Navdar, Choksi, Pervinder K., Sigg, Monika Abedin, Hines, Kelly M., Thompson, Bonne M., Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R., Krup, Alexis Leigh, Eberl, Markus, Byrne, Eamon F.X., Siebold, Christian, Wong, Sunny Y., Renslo, Adam R., Grabe, Michael, McDonald, Jeffrey G., Xu, Libin, Beachy, Philip A., Reiter, Jeremy F.

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Drug resistance confounding prion therapeutics von Berry, David B, Lu, Duo, Geva, Michal, Watts, Joel C, Bhardwaj, Sumita, Oehler, Abby, Renslo, Adam R, DeArmond, Stephen J, Prusiner, Stanley B, Giles, Kurt

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Predicting binding to p-glycoprotein by flexible receptor docking von Dolghih, Elena, Bryant, Clifford, Renslo, Adam R, Jacobson, Matthew P

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Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies von Zhao, Ning, Huang, Yangjie, Wang, Yung-Hua, Muir, Ryan K, Chen, Ying-Chu, Wei, Junnian, Hooshdaran, Nima, Viswanath, Pavithra, Seo, Youngho, Ruggero, Davide, Renslo, Adam R, Evans, Michael J

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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening von Abdulla, Maha-Hamadien, Ruelas, Debbie S, Wolff, Brian, Snedecor, June, Lim, Kee-Chong, Xu, Fengyun, Renslo, Adam R, Williams, Janice, McKerrow, James H, Caffrey, Conor R

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A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons von Kim, Gha-Hyun J, Mo, Han, Liu, Harrison, Wu, Zhihao, Chen, Steven, Zheng, Jiashun, Zhao, Xiang, Nucum, Daryl, Shortland, James, Peng, Longping, Elepano, Mannuel, Tang, Benjamin, Olson, Steven, Paras, Nick, Li, Hao, Renslo, Adam R, Arkin, Michelle R, Huang, Bo, Lu, Bingwei, Sirota, Marina, Guo, Su

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Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis von Admasu, Tesfahun Dessale, Kim, Kristie, Rae, Michael, Avelar, Roberto, Gonciarz, Ryan L., Rebbaa, Abdelhadi, Pedro de Magalhães, João, Renslo, Adam R., Stolzing, Alexandra, Sharma, Amit

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Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X‑ray Crystallography von Nichols, Derek A, Hargis, Jacqueline C, Sanishvili, Ruslan, Jaishankar, Priyadarshini, Defrees, Kyle, Smith, Emmanuel W, Wang, Kenneth K, Prati, Fabio, Renslo, Adam R, Woodcock, H. Lee, Chen, Yu

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2-Aminothiazoles as Therapeutic Leads for Prion Diseases von Gallardo-Godoy, Alejandra, Gever, Joel, Fife, Kimberly L, Silber, B. Michael, Prusiner, Stanley B, Renslo, Adam R

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A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models von Spangler, Benjamin, Fontaine, Shaun D, Shi, Yihui, Sambucetti, Lidia, Mattis, Aras N, Hann, Byron, Wells, James A, Renslo, Adam R

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High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations von Mott, Bryan T., Eastman, Richard T., Guha, Rajarshi, Sherlach, Katy S., Siriwardana, Amila, Shinn, Paul, McKnight, Crystal, Michael, Sam, Lacerda-Queiroz, Norinne, Patel, Paresma R., Khine, Pwint, Sun, Hongmao, Kasbekar, Monica, Aghdam, Nima, Fontaine, Shaun D., Liu, Dongbo, Mierzwa, Tim, Mathews-Griner, Lesley A., Ferrer, Marc, Renslo, Adam R., Inglese, James, Yuan, Jing, Roepe, Paul D., Su, Xin-zhuan, Thomas, Craig J.

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Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system von Osorio, Yaneth, Travi, Bruno L, Renslo, Adam R, Peniche, Alex G, Melby, Peter C

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