Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids von Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, BeGora, Michael, Lohse, Ines, Ngai, Nicholas, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi B, Crawford, Howard C, Arrowsmith, Cheryl, Kalloger, Steve E, Renouf, Daniel J, Connor, Ashton A, Cleary, Sean, Schaeffer, David F, Roehrl, Michael, Tsao, Ming-Sound, Gallinger, Steven, Keller, Gordon, Muthuswamy, Senthil K

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The Role of SOX9 Transcription Factor in Pancreatic and Duodenal Development von Belo, Jamie, Krishnamurthy, Mansa, Oakie, Amanda, Wang, Rennian

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Rfx6 directs islet formation and insulin production in mice and humans von Polychronakos, Constantin, German, Michael S, Smith, Stuart B, Qu, Hui-Qi, Taleb, Nadine, Kishimoto, Nina Y, Scheel, David W, Lu, Yang, Patch, Ann-Marie, Grabs, Rosemary, Wang, Juehu, Lynn, Francis C, Miyatsuka, Takeshi, Mitchell, John, Seerke, Rina, Désir, Julie, Eijnden, Serge Vanden, Abramowicz, Marc, Kacet, Nadine, Weill, Jacques, Renard, Marie-Ève, Gentile, Mattia, Hansen, Inger, Dewar, Ken, Hattersley, Andrew T, Wang, Rennian, Wilson, Maria E, Johnson, Jeffrey D

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N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model von Schuurman, Meg, Wallace, Madison, Sahi, Gurleen, Barillaro, Malina, Zhang, Siyi, Rahman, Mushfiqur, Sawyez, Cynthia, Borradaile, Nica, Wang, Rennian

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β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function von Riopel, Matthew M, Li, Jinming, Liu, Shangxi, Leask, Andrew, Wang, Rennian

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Collagen IV-β1-Integrin Influences INS-1 Cell Insulin Secretion via Enhanced SNARE Protein Expression von Barillaro, Malina, Schuurman, Meg, Wang, Rennian

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Improving the Safety of HED LIBs by Co-Coating Separators with Ceramics and Solid-State Electrolytes von Zhang, Tianhang, Wang, Bo, Qi, Xiaopeng, Chang, Zenghua, Wang, Rennian, Yu, Bing, Yang, Rong, Wang, Jiantao

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Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice von Feng, Zhi-Chao, Donnelly, Lisa, Li, Jinming, Krishnamurthy, Mansa, Riopel, Matthew, Wang, Rennian

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The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease von Wilson, Rachel B., Chen, Yun Jin, Sutherland, Brian G., Sawyez, Cynthia G., Zhang, Richard, Woolnough, Taylor, Hetherington, Alexandra M., Peters, Kia M., Patel, Krisha, Kennelly, John P., Leonard, Kelly-Ann, Schuurman, Meg, Jacobs, René L., Wang, Rennian, Borradaile, Nica M.

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β1 integrin/FAK/ERK signalling pathway is essential for human fetal islet cell differentiation and survival von Saleem, Saira, Li, Jinming, Yee, Siu-Pok, Fellows, George F, Goodyer, Cynthia G, Wang, Rennian

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Integrin α3, But Not β1, Regulates Islet Cell Survival and Function via PI3K/Akt Signaling Pathways von Krishnamurthy, Mansa, Li, Jinming, Fellows, George F, Rosenberg, Lawrence, Goodyer, Cynthia G, Wang, Rennian

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Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty Liver Disease von Wilson, Rachel B, Zhang, Richard, Chen, Yun Jin, Peters, Kia M, Sawyez, Cynthia G, Sutherland, Brian G, Patel, Krisha, Kennelly, John P, Leonard, Kelly-Ann, Jacobs, René L, Wang, Rennian, Borradaile, Nica M

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The Role of ARX in Human Pancreatic Endocrine Specification von Gage, Blair K, Asadi, Ali, Baker, Robert K, Webber, Travis D, Wang, Rennian, Itoh, Masayuki, Hayashi, Masaharu, Miyata, Rie, Akashi, Takumi, Kieffer, Timothy J

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β-Cell Receptor Tyrosine Kinases in Controlling Insulin Secretion and Exocytotic Machinery: c-Kit and Insulin Receptor von Oakie, Amanda, Wang, Rennian

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Aldehyde dehydrogenase 1 activity in the developing human pancreas modulates retinoic acid signalling in mediating islet differentiation and survival von Li, Jinming, Feng, Zhi C., Yeung, Frances S.-H., Wong, Melanie R.-M., Oakie, Amanda, Fellows, George F., Goodyer, Cynthia G., Hess, David A., Wang, Rennian

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Activation of Pancreatic Stellate Cells Is Beneficial for Exocrine but Not Endocrine Cell Differentiation in the Developing Human Pancreas von Li, Jinming, Chen, Bijun, Fellows, George F., Goodyer, Cynthia G., Wang, Rennian

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Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions von Chen, Bijun, Li, Jinming, Fellows, George F, Sun, Zilin, Wang, Rennian

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Aggregation-Induced Enhancement Effect of Gold Nanoparticles on Triplet Excited State von Yang, Wen, Liu, Kunhui, Song, Di, Du, Qian, Wang, Rennian, Su, Hongmei

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Survivin is required for beta-cell mass expansion in the pancreatic duct-ligated mouse model von Wu, Xiaohong, Zhang, Qinfeng, Wang, Xiaojing, Zhu, Jiayu, Xu, Kuangfeng, Okada, Hitoshi, Wang, Rennian, Woo, Minna

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Abstract B45: Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids von Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi, Arrowsmith, Cheryl, Cleary, Sean, Schaeffer, David, Roehrl, Michael, Ming-Sound, Tsao, Gallinger, Steven, Keller, Gordon, Muthuswamy, Senthil

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