The translational landscape of mTOR signalling steers cancer initiation and metastasis von Hsieh, Andrew C., Liu, Yi, Edlind, Merritt P., Ingolia, Nicholas T., Janes, Matthew R., Sher, Annie, Shi, Evan Y., Stumpf, Craig R., Christensen, Carly, Bonham, Michael J., Wang, Shunyou, Ren, Pingda, Martin, Michael, Jessen, Katti, Feldman, Morris E., Weissman, Jonathan S., Shokat, Kevan M., Rommel, Christian, Ruggero, Davide

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Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor von Fruman, David A, Janes, Matthew R, Limon, Jose J, So, Lomon, Chen, Jing, Lim, Raymond J, Chavez, Melissa A, Vu, Collin, Lilly, Michael B, Mallya, Sharmila, Ong, S Tiong, Konopleva, Marina, Martin, Michael B, Ren, Pingda, Liu, Yi, Rommel, Christian

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Defining the role of TORC1/2 in multiple myeloma von Maiso, Patricia, Liu, Yi, Morgan, Brittany, Azab, Abdel Kareem, Ren, Pingda, Martin, Michel B., Zhang, Yong, Liu, Yang, Sacco, Antonio, Ngo, Hai, Azab, Feda, Quang, Phong, Rodig, Scott J., Lin, Charles P., Roccaro, Aldo M., Rommel, Christian, Ghobrial, Irene M.

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor von Janes, Matthew R., Zhang, Jingchuan, Li, Lian-Sheng, Hansen, Rasmus, Peters, Ulf, Guo, Xin, Chen, Yuching, Babbar, Anjali, Firdaus, Sarah J., Darjania, Levan, Feng, Jun, Chen, Jeffrey H., Li, Shuangwei, Li, Shisheng, Long, Yun O., Thach, Carol, Liu, Yuan, Zarieh, Ata, Ely, Tess, Kucharski, Jeff M., Kessler, Linda V., Wu, Tao, Yu, Ke, Wang, Yi, Yao, Yvonne, Deng, Xiaohu, Zarrinkar, Patrick P., Brehmer, Dirk, Dhanak, Dashyant, Lorenzi, Matthew V., Hu-Lowe, Dana, Patricelli, Matthew P., Ren, Pingda, Liu, Yi

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Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I von Zhang, Guobao, Ren, Pingda, Gray, Nathanael S., Sim, Taebo, Liu, Yi, Wang, Xia, Che, Jianwei, Tian, Shin-Shay, Sandberg, Mark L., Spalding, Tracy A., Romeo, Russell, Iskandar, Maya, Chow, Donald, Martin Seidel, H., Karanewsky, Donald S., He, Yun

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Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State von Patricelli, Matthew P, Janes, Matthew R, Li, Lian-Sheng, Hansen, Rasmus, Peters, Ulf, Kessler, Linda V, Chen, Yuching, Kucharski, Jeff M, Feng, Jun, Ely, Tess, Chen, Jeffrey H, Firdaus, Sarah J, Babbar, Anjali, Ren, Pingda, Liu, Yi

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Catalytic Asymmetric Benzylic C−H Activation by Means of Carbenoid-Induced C−H Insertions von Davies, Huw M. L, Jin, Qihui, Ren, Pingda, Kovalevsky, Andrey Yu

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Catalytic Asymmetric C−H Activation of Silyl Enol Ethers as an Equivalent of an Asymmetric Michael Reaction von Davies, Huw M. L, Ren, Pingda

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Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia von Klossowski, Szymon, Miao, Hongzhi, Kempinska, Katarzyna, Wu, Tao, Purohit, Trupta, Kim, EunGi, Linhares, Brian M, Chen, Dong, Jih, Gloria, Perkey, Eric, Huang, Huang, He, Miao, Wen, Bo, Wang, Yi, Yu, Ke, Lee, Stanley Chun-Wei, Danet-Desnoyers, Gwenn, Trotman, Winifred, Kandarpa, Malathi, Cotton, Anitria, Abdel-Wahab, Omar, Lei, Hongwei, Dou, Yali, Guzman, Monica, Peterson, Luke, Gruber, Tanja, Choi, Sarah, Sun, Duxin, Ren, Pingda, Li, Lian-Sheng, Liu, Yi, Burrows, Francis, Maillard, Ivan, Cierpicki, Tomasz, Grembecka, Jolanta

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Catalytic Asymmetric Allylic C−H Activation as a Surrogate of the Asymmetric Claisen Rearrangement von Davies, Huw M. L, Ren, Pingda, Jin, Qihui

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Solid Form Selection and Process Development of KO-947 Drug Substances von Mei, Bo, Zhu, Linrong, Guo, Yushen, Wu, Tao, Ren, Pingda, Deng, Xiaohu

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Development of a Recycling Process for an Industrial-Scale Production of Tipifarnib von Deng, Xiaohu, Ren, Pingda, Mai, Wanping, Fu, Thomas, Zhang, Hang, Cai, Xianfeng, Wang, Lu

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Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II von Zhang, Guobao, Ren, Pingda, Gray, Nathanael S., Sim, Taebo, Wang, Xia, Liu, Yi, Che, Jianwei, Dong, Weitong, Tian, Shin-Shay, Sandberg, Mark L., Spalding, Tracy A., Romeo, Russell, Iskandar, Maya, Wang, Zhiliang, Seidel, H. Martin, Karanewsky, Donald S., He, Yun

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From Lab Formulation Development to CTM Manufacturing of KO-947 Injectable Drug Products: a Case Study and Lessons Learned von Deng, Xiaohu, Ren, Pingda, Mai, Wanping, Wang, Yi, Zhang, Yuanyang, Wu, Hongbing, Xie, Yinwei, Chen, Huazhen

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Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors von Allison, Brett D., Deng, Xiaohu, Li, Lian-Sheng, Liang, Jimmy, Mani, Neelakandha S., Ren, Pingda, Sales, Zachary S.

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PI3 Kinase δ Is a Key Regulator of Synoviocyte Function in Rheumatoid Arthritis von Bartok, Beatrix, Boyle, David L, Liu, Yi, Ren, Pingda, Ball, Scott T, Bugbee, William D, Rommel, Christian, Firestein, Gary S

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Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102 von Yang, Xiaogen, Li, Zhiwen, Xu, Wenwen, Zhu, Guanming, Feng, Xiantong, Zhang, Jun, Zhao, Hongbin, Chen, Yuyin, Kong, Jianshe, Mai, Wanping, Li, Lian-Sheng, Pippel, Daniel J., Ren, Pingda, Deng, Xiaohu

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The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors von Williams, Roger L, Berndt, Alex, Miller, Simon, Williams, Olusegun, Le, Daniel D, Houseman, Benjamin T, Pacold, Joseph I, Gorrec, Fabrice, Hon, Wai-Ching, Ren, Pingda, Liu, Yi, Rommel, Christian, Gaillard, Pascale, Rückle, Thomas, Schwarz, Matthias K, Shokat, Kevan M, Shaw, Jeffrey P

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Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRAS G12C Inhibitor ARS-2102 von Yang, Xiaogen, Li, Zhiwen, Xu, Wenwen, Zhu, Guanming, Feng, Xiantong, Zhang, Jun, Zhao, Hongbin, Chen, Yuyin, Kong, Jianshe, Mai, Wanping, Li, Lian-Sheng, Pippel, Daniel J., Ren, Pingda, Deng, Xiaohu

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Abstract 686: Drugging an undruggable pocket: The biochemical mechanism of covalent KRASG12C inhibitors von Hansen, Rasmus, Peters, Ulf, Babbar, Anjali, Chen, Yuching, Feng, Jun, Janes, Matthew R., Li, Liansheng, Ren, Pingda, Liu, Yi, Zarrinkar, Patrick P.

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