Bottom-up Meets Top-down: Complementary Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling for Regulatory Approval of a Dosing Algorithm of Valganciclovi... von Jorga, K, Chavanne, C, Frey, N, Lave, T, Lukacova, V, Parrott, N, Peck, R, Reigner, B

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A Physiologically Based Pharmacokinetic Model for Ganciclovir and Its Prodrug Valganciclovir in Adults and Children von Lukacova, V., Goelzer, P., Reddy, M., Greig, G., Reigner, B., Parrott, N.

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Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer von MACKEAN, M, PLANTING, A, TWELVES, C, SCHELLENS, J, ALLMAN, D, OSTERWALDER, B, REIGNER, B, GRIFFIN, T, KAYE, S, VERWEIJ, J

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Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine von BUDMAN, D. R, MEROPOL, N. J, REIGNER, B, CREAVEN, P. J, LICHTMAN, S. M, BERGHORN, E, BEHR, J, GORDON, R. J, OSTERWALDER, B, GRIFFIN, T

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Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients von REIGNER, B, VERWEIJ, J, OSTERWALDER, B, DIRIX, L, CASSIDY, J, TWELVES, C, ALLMAN, D, WEIDEKAMM, E, ROOS, B, BANKEN, L, UTOH, M

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Success rates and adherence to antiretroviral therapy among treatment-naïve patients in Davao City, Philippines: A ten-year retrospective cohort study von Escartin, Reigner Jay B., Servillon, Rvin John T., Legarta, Jesille Mae A., Arriola, Stephanie Kate G., Brahim, Princess Faiqah A., Braza, Dennis Louis M., Salva, Aireen V., Hinay, Alfredo A.

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A phase I and pharmacokinetic study of the combination of capecitabine and docetaxel in patients with advanced solid tumours von PRONK, L. C, VASEY, P, SPARREBOOM, A, REIGNER, B, PLANTING, A. S. T, GORDON, R. J, OSTERWALDER, B, VERWEIJ, J, TWELVES, C

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An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche von REIGNER, B. G, WILLIAMS, P. E. O, PATEL, I. H, STEIMER, J.-L, PECK, C, VAN BRUMMELEN, P

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Clinical pharmacokinetics of capecitabine von REIGNER, Bruno, BLESCH, Karen, WEIDEKAMM, Erhard

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A Phase I study of capecitabine in combination with oral leucovorin in patients with intractable solid tumors von CASSIDY, J, DIRIX, L, BISSETT, D, REIGNER, B, GRIFFIN, T, ALLMAN, D, OSTERWALDER, B, VAN OOSTEROM, A. T

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Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients von SCHÜLLER, J, CASSIDY, J, DUMONT, E, ROOS, B, DURSTON, S, BANKEN, L, UTOH, M, MORI, K, WEIDEKAMM, E, REIGNER, B

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Significant Effect of Capecitabine on the Pharmacokinetics and Pharmacodynamics of Warfarin in Patients With Cancer von CAMIDGE, Ross, REIGNER, Bruno, CASSIDY, Jim, GRANGE, Susan, ABT, Markus, WEIDEKAMM, Erhard, JODRELL, Duncan

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Population pharmacokinetic analysis of the major metabolites of capecitabine von GIESCHKE, R, REIGNER, B, BLESCH, K. S, STEIMER, J.-L

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Factors influencing elimination and distribution of fleroxacin: metaanalysis of individual data from 10 pharmacokinetic studies von Reigner, B G, Welker, H A

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations von LAVE, T, COASSOLO, P, REIGNER, B

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Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients von Gieschke, Ronald, Burger, Hans‐Ulrich, Reigner, Bruno, Blesch, Karen S., Steimer, Jean‐Louis

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Effect of Hepatic Dysfunction due to Liver Metastases on the Pharmacokinetics of Capecitabine and Its Metabolites von TWELVES, C, GLYNNE-JONES, R, CASSIDY, J, SCHÜLLER, J, GOGGIN, T, ROOS, B, BANKEN, L, UTOH, M, WEIDEKAMM, E, REIGNER, B

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Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients von POOLE, Christopher, GARDINER, Jill, TWELVES, Chris, JOHNSTON, Patrick, HARPER, Peter, CASSIDY, Jim, MONKHOUSE, Jayne, BANKEN, Ludger, WEIDEKAMM, Erhard, REIGNER, Bruno

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Estimating the starting dose for entry into humans: principles and practice von REIGNER, Bruno G, BLESCH, Karen Smith

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DISPOSITION, BIOAVAILABILITY, AND SERUM-PROTEIN BINDING OF PENTACHLOROPHENOL IN THE B6C3F1 MOUSE von REIGNER, BG, RIGOD, JF, TOZER, TN

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