Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multipl... von Sazinsky, Stephen, Zafari, Mohammad, Klebanov, Boris, Ritter, Jessica, Nguyen, Phuong A, Phennicie, Ryan T, Wahle, Joe, Kauffman, Kevin J, Razlog, Maja, Manfra, Denise, Feldman, Igor, Novobrantseva, Tatiana

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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM von Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

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Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics von Geddie, Melissa L, Kirpotin, Dmitri B, Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C, Lugovskoy, Alexey A

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A novel screening method to assess developability of antibody-like molecules von Kohli, Neeraj, Jain, Nidhi, Geddie, Melissa L, Razlog, Maja, Xu, Lihui, Lugovskoy, Alexey A

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MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors von Fitzgerald, Jonathan B, Johnson, Bryan W, Baum, Jason, Adams, Sharlene, Iadevaia, Sergio, Tang, Jian, Rimkunas, Victoria, Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Razlog, Maja, Jiao, Yang, Harms, Brian D, Olivier, Jr, Kenneth J, Schoeberl, Birgit, Nielsen, Ulrik B, Lugovskoy, Alexey A

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Abstract 2491: Engineering and preclinical activity of MM-201, a best-in-class TRAIL receptor agonist von Sawyer, Andrew J., Ghassemifar, Sara, Wong, Christina, Richards, Jennifer, Grabow, Stephanie, Suchy, James, Koshkaryev, Alexander, Razlog, Maja, Tam, Eric, Drummond, Daryl C.

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Abstract 700: Development of a second-generation TRAIL agonist and predictive biomarker profile for colorectal cancer von Ghassemifar, Sara, Hashambhoy-Ramsay, Yasmin, Yuzugullu, Haluk, Utermark, Tamara, Paragas, Violette, Maiwald, Tim, Luus, Lia, Razlog, Maja, Hudson, Hannah, Chai, Diane, Schoeberl, Birgit, Reynolds, C. Patrick, Sorger, Peter, Sawyer, Andrew J., Drummond, Daryl C., Tam, Eric

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Abstract 3270: Mechanism of action of a novel agonist TNFR2 antibody that induces co-stimulation of T cells and promotes robust anti-tumor immunity von Fulton, Ross B., Camblin, Adam, Sampson, James F., Richards, Jennifer, Wong, Christina, Koshkaryev, Alexander, Luus, Lia, Jiao, Yang, Xu, Lihui, Paragas, Violette, Razlog, Maja, Muda, Marco, Tam, Eric M., Drummond, Daryl C., Raue, Andreas

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Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor Growth von Novobrantseva, Tatiana, Manfra, Denise, Ritter, Jessica, Razlog, Maja, O'Nuallain, Brian, Zafari, Mohammad, Nowakowska, Dominika, Basinski, Sara, Phennicie, Ryan T, Nguyen, Phuong A, Brehm, Michael A, Sazinsky, Stephen, Feldman, Igor

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Abstract 22: MM-161, a first-in-class pan-FGFR antibody von Dake, Tamara, Finn, Greg, Geddie, Melissa, Kohli, Neeraj, Razlog, Maja, Xu, Lihui, Paragas, Violette, Yuzugullu, Haluk, Ghassemifar, Sara, Hashambhoy-Ramsay, Yasmin, McDonagh, Charlotte, Muda, Marco, Schoeberl, Birgit

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Abstract 4846: MM-401, a novel anti-TNFR2 antibody that induces T cell co-stimulation, robust anti-tumor activity and immune memory von Richards, Jennifer, Wong, Christina, Koshkaryev, Alexander, Fulton, Ross, Camblin, Adam, Sampson, James, Luus, Lia, Suchy, James, Grabow, Stephanie, Kurella, Vinodh, Kumar, Sandeep, Lulo, James, Qiu, James, Jiao, Yang, Xu, Lihui, Paragas, Violette, Razlog, Maja, Muda, Marco, Tam, Eric, Raue, Andreas, Drummond, Daryl

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Abstract 555: A novel human TNFR2 antibody (MM-401) modulates T cell responses in anti-cancer immunity von Sampson, James F., Kurella, Vinodh B., Paragas, Violette, Kumar, Sandeep, Lulo, James E., Qiu, James A., Razlog, Maja, Fulton, Ross B., Camblin, Adam J., Richards, Jennifer M., Wong, Christina S., Koshkaryev, Alexander, Suchy, James J., Grabow, Stephanie, Muda, Marco, Raue, Andreas, Drummond, Daryl C., Tam, Eric M.

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A novel TNFR2 antibody induces T cell co-stimulation and promotes durable anti-tumor immunity von Sampson, James F, Fulton, Ross B, Kurella, Vinodh B, Richards, Jennifer M, Camblin, Adam J, Wong, Christina S, Koshkaryev, Alexander, Lulo, James E, Qiu, James A, Kumar, Sandeep, Luus, Lia, Jiao, Yang, Suchy, James, Grabow, Stephanie, Paragas, Violette, Razlog, Maja, Xi, Lihui, Muda, Marco, Drummond, Daryl C, Tam, Eric M, Raue, Andreas

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Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting von Geddie, Melissa L, Kohli, Neeraj, Kirpotin, Dmitri B, Razlog, Maja, Jiao, Yang, Kornaga, Tad, Rennard, Rachel, Xu, Lihui, Schoerberl, Birgit, Marks, James D, Drummond, Daryl C, Lugovskoy, Alexey A

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Rapid optimization and prototyping for therapeutic antibody-like molecules von Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Jiao, Yang, Razlog, Maja, Zhang, Kathy, Baum, Jason, Johnson, Bryan, Tang, Jian, Schoeberl, Birgit, Fitzgerald, Jonathan, Nielsen, Ulrik, Lugovskoy, Alexey A.

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ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF von NOVOBRANTSEVA, Tatiana, I, CULYBA, Elizabeth, NGUYEN, Phuong, Anh, SAZINSKY, Stephen, L, RAZLOG, Maja, FELDMAN, Igor

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ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF von Novobrantseva, Tatiana I, Sazinsky, Stephen L, Culyba, Elizabeth, Nguyen, Phuong Anh, Razlog, Maja, Feldman, Igor

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ANTI-VSIG4 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF von NOVOBRANTSEVA, Tatiana, I, CULYBA, Elizabeth, NGUYEN, Phuong, Anh, SAZINSKY, Stephen, L, RAZLOG, Maja, FELDMAN, Igor

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Anti-VSIG4 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof von CULYBA, Elizabeth, NGUYEN, Phuong Anh, NOVOBRANTSEVA, Tatiana I, SAZINSKY, Stephen L, RAZLOG, Maja, FELDMAN, Igor

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Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics von Geddie, Melissa L., Kirpotin, Dmitri B., Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C., Lugovskoy, Alexey A.

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