Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W

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Chiral oxazoline route to enantiomerically pure biphenyls: magnesio and copper mediated asymmetric hetero- and homo-coupling reactions von Meyers, A.I, Nelson, Todd D, Moorlag, Henk, Rawson, David J, Meier, Anton

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Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes von Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R Ian, Stupple, Paul A, West, Christopher W

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The design and synthesis of a novel series of indole derived selective ETA antagonists von RAWSON, David J, DACK, Kevin N, DICKINSON, Roger P, JAMES, Kim

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Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain von Bagal, Sharan K., Bungay, Peter J., Denton, Stephen M., Gibson, Karl R., Glossop, Melanie S., Hay, Tanya L., Kemp, Mark I., Lane, Charlotte A. L., Lewis, Mark L., Maw, Graham N., Million, William A., Payne, C. Elizabeth, Poinsard, Cedric, Rawson, David J., Stammen, Blanda L., Stevens, Edward B., Thompson, Lisa R.

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The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics von Rawson, David J., Ballard, Stephen, Barber, Christopher, Barker, Laura, Beaumont, Kevin, Bunnage, Mark, Cole, Susan, Corless, Martin, Denton, Stephen, Ellis, David, Floc’h, Marion, Foster, Laura, Gosset, James, Holmwood, Frances, Lane, Charlotte, Leahy, David, Mathias, John, Maw, Graham, Million, William, Poinsard, Cedric, Price, Jenny, Russel, Rachel, Street, Stephen, Watson, Lesa

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Part 3: Design and synthesis of proline-derived α₂δ ligands von Rawson, David J, Brugier, Delphine, Harrison, Anthony, Hough, Jo, Newman, Julie, Otterburn, Joe, Maw, Graham N, Price, Jenny, Thompson, Lisa R, Turnpenny, Paul, Warren, Andrew N

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Part 2: Design, synthesis and evaluation of hydroxyproline-derived α₂δ ligands von Rawson, David J, Brugier, Delphine, Harrison, Anthony, Hough, Jo, Newman, Julie, Otterburn, Joe, Maw, Graham N, Price, Jenny, Thompson, Lisa R, Turnpenny, Paul, Warren, Andrew N

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A Novel Series of Potent and Selective PDE5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability von Allerton, Charlotte M. N, Barber, Christopher G, Beaumont, Kevin C, Brown, David G, Cole, Susan M, Ellis, David, Lane, Charlotte A. L, Maw, Graham N, Mount, Natalie M, Rawson, David J, Robinson, Colin M, Street, Stephen D. A, Summerhill, Nicholas W

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Part 1: N-Alkylated glycines as potent α₂δ ligands von Thompson, Lisa R, Blakemore, David C, Brugier, Delphine, Bryans, Justin S, Chu, Wai-Lam A, Maw, Graham N, Poinsard, Cedric, Rawson, David J, Warren, Andrew N

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Asymmetric tandem additions to chiral naphthyloxazolines. A new and potent chiral auxiliary resulting in a major improvement in convenience and efficiency von Rawson, David J, Meyers, A. I

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A highly stereoselective synthesis of axially chiral biaryls. Application to the synthesis of a potential chiral catalysts von Meyers, A.I., Meier, Anton, Rawson, David J.

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Part 3: Design and synthesis of proline-derived α 2δ ligands von Rawson, David J., Brugier, Delphine, Harrison, Anthony, Hough, Jo, Newman, Julie, Otterburn, Joe, Maw, Graham N., Price, Jenny, Thompson, Lisa R., Turnpenny, Paul, Warren, Andrew N.

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Part 2: Design, synthesis and evaluation of hydroxyproline-derived α 2δ ligands von Rawson, David J., Brugier, Delphine, Harrison, Anthony, Hough, Jo, Newman, Julie, Otterburn, Joe, Maw, Graham N., Price, Jenny, Thompson, Lisa R., Turnpenny, Paul, Warren, Andrew N.

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Part 1: N-Alkylated glycines as potent alpha sub(2[delta] ligands) von Thompson, Lisa R, Blakemore, David C, Brugier, Delphine, Bryans, Justin S, Chu, Wai-Lam A, Maw, Graham N, Poinsard, Cedric, Rawson, David J, Warren, Andrew N

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Studies in macrolide synthesis: A highly stereoselective synthesis of (+)-(9 S)-dihydroerythronolide a using macrocyclic stereocontrol von Paterson, Ian, Rawson, David J.

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Highly potent and selective Na V 1.7 inhibitors for use as intravenous agents and chemical probes von Storer, R Ian, Pike, Andy, Swain, Nigel A, Alexandrou, Aristos J, Bechle, Bruce M, Blakemore, David C, Brown, Alan D, Castle, Neil A, Corbett, Matthew S, Flanagan, Neil J, Fengas, David, Johnson, M Scott, Jones, Lyn H, Marron, Brian E, Payne, C Elizabeth, Printzenhoff, David, Rawson, David J, Rose, Colin R, Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W, Torella, Rubben, Tseng, Elaine, Warmus, Joseph S

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Part 2: Design, synthesis and evaluation of hydroxyproline-derived alpha sub(2[delta] ligands) von Rawson, David J, Brugier, Delphine, Harrison, Anthony, Hough, Jo, Newman, Julie, Otterburn, Joe, Maw, Graham N, Price, Jenny, Thompson, Lisa R, Turnpenny, Paul, Warren, Andrew N

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Part 3: Design and synthesis of proline-derived alpha sub(2[delta] ligands) von Rawson, David J, Brugier, Delphine, Harrison, Anthony, Hough, Jo, Newman, Julie, Otterburn, Joe, Maw, Graham N, Price, Jenny, Thompson, Lisa R, Turnpenny, Paul, Warren, Andrew N

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