Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy von Chari, Ravi V. J., Miller, Michael L., Widdison, Wayne C.

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Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs von Chari, Ravi V. J

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Antibody conjugate therapeutics: challenges and potential von Teicher, Beverly A, Chari, Ravi V J

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Expanding the Reach of Antibody–Drug Conjugates von Chari, Ravi V. J

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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate von Lewis Phillips, Gail D, Li, Guangmin, Dugger, Debra L, Crocker, Lisa M, Parsons, Kathryn L, Mai, Elaine, Blättler, Walter A, Lambert, John M, Chari, Ravi V J, Lutz, Robert J, Wong, Wai Lee T, Jacobson, Frederic S, Koeppen, Hartmut, Schwall, Ralph H, Kenkare-Mitra, Sara R, Spencer, Susan D, Sliwkowski, Mark X

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Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer von Lambert, John M, Chari, Ravi V. J

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Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance von KOVTUN, Yelena V, AUDETTE, Charlene A, LAI, Katharine C, WIDDISON, Wayne C, KELLOGG, Brenda, JOHNSON, Holly, PINKAS, Jan, LUTZ, Robert J, SINGH, Rajeeva, GOLDMACHER, Victor S, CHARI, Ravi V. J, MAYO, Michele F, JONES, Gregory E, DOHERTY, Heather, MALONEY, Erin K, ERICKSON, Hans K, XIUXIA SUN, WILHELM, Sharon, AB, Olga

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Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates von Zhao, Robert Y, Wilhelm, Sharon D, Audette, Charlene, Jones, Gregory, Leece, Barbara A, Lazar, Alexandru C, Goldmacher, Victor S, Singh, Rajeeva, Kovtun, Yelena, Widdison, Wayne C, Lambert, John M, Chari, Ravi V. J

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A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity von Miller, Michael L, Fishkin, Nathan E, Li, Wei, Whiteman, Kathleen R, Kovtun, Yelena, Reid, Emily E, Archer, Katie E, Maloney, Erin K, Audette, Charlene A, Mayo, Michele F, Wilhelm, Alan, Modafferi, Holly A, Singh, Rajeeva, Pinkas, Jan, Goldmacher, Victor, Lambert, John M, Chari, Ravi V J

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Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage von Kellogg, Brenda A, Garrett, Lisa, Kovtun, Yelena, Lai, Katharine C, Leece, Barbara, Miller, Michael, Payne, Gillian, Steeves, Rita, Whiteman, Kathleen R, Widdison, Wayne, Xie, Hongsheng, Singh, Rajeeva, Chari, Ravi V. J, Lambert, John M, Lutz, Robert J

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Optimizing Lysosomal Activation of Antibody–Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers von Salomon, Paulin L, Reid, Emily E, Archer, Katie E, Harris, Luke, Maloney, Erin K, Wilhelm, Alan J, Miller, Michael L, Chari, Ravi V. J, Keating, Thomas A, Singh, Rajeeva

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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs) von Miller, Michael L, Shizuka, Manami, Wilhelm, Alan, Salomon, Paulin, Reid, Emily E, Lanieri, Leanne, Sikka, Surina, Maloney, Erin K, Harvey, Lauren, Qiu, Qifeng, Archer, Katie E, Bai, Chen, Vitharana, Dilrukshi, Harris, Luke, Singh, Rajeeva, Ponte, Jose F, Yoder, Nicholas C, Kovtun, Yelena, Lai, Katharine C, Ab, Olga, Pinkas, Jan, Keating, Thomas A, Chari, Ravi V J

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A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells von Kovtun, Yelena, Jones, Gregory E., Adams, Sharlene, Harvey, Lauren, Audette, Charlene A., Wilhelm, Alan, Bai, Chen, Rui, Lingyun, Laleau, Rassol, Liu, Fenghua, Ab, Olga, Setiady, Yulius, Yoder, Nicholas C., Goldmacher, Victor S., Chari, Ravi V.J., Pinkas, Jan, Chittenden, Thomas

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Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates von Li, Wei, Veale, Karen H, Qiu, Qifeng, Sinkevicius, Kerstin W, Maloney, Erin K, Costoplus, Juliet A, Lau, Janet, Evans, Helen L, Setiady, Yulius, Ab, Olga, Abbott, Stephen M, Lee, Jenny, Wisitpitthaya, Somsinee, Skaletskaya, Anna, Wang, Lintao, Keating, Thomas A, Chari, Ravi V. J, Widdison, Wayne C

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Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer von Widdison, Wayne C, Wilhelm, Sharon D, Cavanagh, Emily E, Whiteman, Kathleen R, Leece, Barbara A, Kovtun, Yelena, Goldmacher, Victor S, Xie, Hongsheng, Steeves, Rita M, Lutz, Robert J, Zhao, Robert, Wang, Lintao, Blättler, Walter A, Chari, Ravi V. J

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Antibody–Drug Conjugates with Indolinobenzodiazepine Dimer Payloads: DNA-Binding Mechanism of Indolinobenzodiazepine Dimer Catabolites in Target Cancer Cells von Singh, Rajeeva, Reid, Emily E, Harris, Luke, Salomon, Paulin L, Miller, Michael L, Chari, Ravi V. J, Keating, Thomas A

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A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells von Singh, Rajeeva, Setiady, Yulius Y, Ponte, Jose, Kovtun, Yelena V, Lai, Katharine C, Hong, E Erica, Fishkin, Nathan, Dong, Ling, Jones, Gregory E, Coccia, Jennifer A, Lanieri, Leanne, Veale, Karen, Costoplus, Juliet A, Skaletskaya, Anna, Gabriel, Rabih, Salomon, Paulin, Wu, Rui, Qiu, Qifeng, Erickson, Hans K, Lambert, John M, Chari, Ravi V J, Widdison, Wayne C

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Synthesis and Biological Evaluation of Antibody Conjugates of Phosphate Prodrugs of Cytotoxic DNA Alkylators for the Targeted Treatment of Cancer von Zhao, Robert Yongxin, Erickson, Hans K, Leece, Barbara A, Reid, Emily E, Goldmacher, Victor S, Lambert, John M, Chari, Ravi V. J

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Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing von Widdison, Wayne C, Ponte, Jose F, Coccia, Jennifer A, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Hong, E. Erica, Wu, Rui, Qiu, Qifeng, Singh, Rajeeva, Salomon, Paulin, Fishkin, Nathan, Harris, Luke, Maloney, Erin K, Kovtun, Yelena, Veale, Karen, Wilhelm, Sharon D, Audette, Charlene A, Costoplus, Juliet A, Chari, Ravi V. J

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Folate receptor-specific antitumor activity of EC131, a folate-maytansinoid conjugate von REDDY, Joseph A, WESTRICK, Elaine, SANTHAPURAM, Hari K. R, HOWARD, Stephen J, MILLER, Michael L, VETZEL, Marilynn, VLAHOV, Iontcho, CHARI, Ravi V. J, GOLDMACHER, Victor S, LEAMON, Christopher P

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