The expanding role of prodrugs in contemporary drug design and development von Rautio, Jarkko, Meanwell, Nicholas A., Di, Li, Hageman, Michael J.

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Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders von Bahadur, Shiv, Pardhi, Dinesh M., Rautio, Jarkko, Rosenholm, Jessica M., Pathak, Kamla

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Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma von Srisongkram, Tarapong, Bahrami, Katayun, Järvinen, Juulia, Timonen, Juri, Rautio, Jarkko, Weerapreeyakul, Natthida

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Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells von Srisongkram, Tarapong, Weerapreeyakul, Natthida, Kärkkäinen, Jussi, Rautio, Jarkko

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Towards New Delivery Agents for Boron Neutron Capture Therapy: Synthesis and In Vitro Evaluation of a Set of Fluorinated Carbohydrate Derivatives von Matović, Jelena, Järvinen, Juulia, Sokka, Iris K, Imlimthan, Surachet, Aitio, Olli, Sarparanta, Mirkka, Rautio, Jarkko, Ekholm, Filip S

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Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine von Peura, Lauri, Malmioja, Kalle, Huttunen, Kristiina, Leppänen, Jukka, Hämäläinen, Miia, Forsberg, Markus M., Rautio, Jarkko, Laine, Krista

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Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT) von Järvinen, Juulia, Pulkkinen, Herkko, Rautio, Jarkko, Timonen, Juri M

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Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats von Jalkanen, Aaro J., Ihalainen, Jouni, Lehtonen, Marko, Forsberg, Markus M., Rautio, Jarkko, Huttunen, Kristiina M., Gynther, Mikko

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Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7 von Pocasap, Piman, Weerapreeyakul, Natthida, Timonen, Juri, Jaervinen, Juulia, Leppanen, Jukka, Karkkainen, Jussi, Rautio, Jarkko

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Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments von Zingale, Elide, Bonaccorso, Angela, D'Amico, Agata Grazia, Lombardo, Rosamaria, D'Agata, Velia, Rautio, Jarkko, Pignatello, Rosario

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Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake von Kärkkäinen, Jussi, Gynther, Mikko, Kokkola, Tarja, Petsalo, Aleksanteri, Auriola, Seppo, Lahtela-Kakkonen, Maija, Laine, Krista, Rautio, Jarkko, Huttunen, Kristiina M.

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Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho-... von Matovic, Jelena, Jarvinen, Juulia, Sokka, Iris K., Imlimthan, Surachet, Raitanen, Jan-Erik, Montaser, Ahmed, Maaheimo, Hannu, Huttunen, Kristiina M., Peraniemi, Sirpa, Airaksinen, Anu J., Sarparanta, Mirkka, Johansson, Mikael P., Rautio, Jarkko, Ekholm, Filip S.

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Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure von Gynther, Mikko, Peura, Lauri, Vernerová, Monika, Leppänen, Jukka, Kärkkäinen, Jussi, Lehtonen, Marko, Rautio, Jarkko, Huttunen, Kristiina M.

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Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery von Peura, Lauri, Malmioja, Kalle, Laine, Krista, Leppänen, Jukka, Gynther, Mikko, Isotalo, Antti, Rautio, Jarkko

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Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835 von Krasavin, Mikhail, Lukin, Alexey, Bagnyukova, Daria, Zhurilo, Nikolay, Zahanich, Ihor, Zozulya, Sergey, Ihalainen, Jouni, Forsberg, Markus M., Lehtonen, Marko, Rautio, Jarkko, Moore, Daniel, Tikhonova, Irina G.

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Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation von Kärkkäinen, Jussi, Laitinen, Tuomo, Markowicz-Piasecka, Magdalena, Montaser, Ahmed, Lehtonen, Marko, Rautio, Jarkko, Gynther, Mikko, Poso, Antti, Huttunen, Kristiina M.

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Design for optimized topical delivery : Prodrugs and a paradigm change von SLOAN, Kenneth B, WASDO, Scott C, RAUTIO, Jarkko

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High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed r... von Sangthong, Sarita, Weerapreeyakul, Natthida, Lehtonen, Marko, Leppanen, Jukka, Rautio, Jarkko

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Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion von Ylikangas, Henna, Peura, Lauri, Malmioja, Kalle, Leppänen, Jukka, Laine, Krista, Poso, Antti, Lahtela-Kakkonen, Maija, Rautio, Jarkko

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Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats von Gynther, Mikko, Ropponen, Jarmo, Laine, Krista, Leppänen, Jukka, Haapakoski, Paula, Peura, Lauri, Järvinen, Tomi, Rautio, Jarkko

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