iGEAK: an interactive gene expression analysis kit for seamless workflow using the R/shiny platform von Choi, Kwangmin, Ratner, Nancy

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Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas von Dombi, Eva, Baldwin, Andrea, Marcus, Leigh J, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Whitcomb, Patricia, Martin, Staci, Aschbacher-Smith, Lindsey E, Rizvi, Tilat A, Wu, Jianqiang, Ershler, Rachel, Wolters, Pamela, Therrien, Janet, Glod, John, Belasco, Jean B, Schorry, Elizabeth, Brofferio, Alessandra, Starosta, Amy J, Gillespie, Andrea, Doyle, Austin L, Ratner, Nancy, Widemann, Brigitte C

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Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis von Heinrich, Anna, Potter, Sarah J., Guo, Li, Ratner, Nancy, DeFalco, Tony

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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors von Jessen, Walter J, Miller, Shyra J, Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A, Brundage, Meghan E, Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P, Giovannini, Marco, Aronow, Bruce J, Cripe, Timothy P, Ratner, Nancy

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Merlin tumor suppressor function is regulated by PIP2-mediated dimerization von Hennigan, Robert F, Thomson, Craig S, Stachowski, Kye, Nassar, Nicolas, Ratner, Nancy

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How does the Schwann cell lineage form tumors in NF1? von Carroll, Steven L., Ratner, Nancy

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Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis von Wu, Lai Man Natalie, Deng, Yaqi, Wang, Jincheng, Zhao, Chuntao, Wang, Jiajia, Rao, Rohit, Xu, Lingli, Zhou, Wenhao, Choi, Kwangmin, Rizvi, Tilat A., Remke, Marc, Rubin, Joshua B., Johnson, Randy L., Carroll, Thomas J., Stemmer-Rachamimov, Anat O., Wu, Jianqiang, Zheng, Yi, Xin, Mei, Ratner, Nancy, Lu, Q. Richard

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Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future von Reilly, Karlyne M, Kim, AeRang, Blakely, Jaishri, Ferner, Rosalie E, Gutmann, David H, Legius, Eric, Miettinen, Markku M, Randall, R Lor, Ratner, Nancy, Jumbé, N L, Bakker, Annette, Viskochil, David, Widemann, Brigitte C, Stewart, Douglas R

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Rac1 controls Schwann cell myelination through cAMP and NF2/merlin von Guo, Li, Moon, Chandra, Niehaus, Karen, Zheng, Yi, Ratner, Nancy

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Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis von Rahrmann, Eric P, Watson, Adrienne L, Keng, Vincent W, Choi, Kwangmin, Moriarity, Branden S, Beckmann, Dominic A, Wolf, Natalie K, Sarver, Aaron, Collins, Margaret H, Moertel, Christopher L, Wallace, Margaret R, Gel, Bernat, Serra, Eduard, Ratner, Nancy, Largaespada, David A

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Neurofibromatosis type 1: modeling CNS dysfunction von Gutmann, David H, Parada, Luis F, Silva, Alcino J, Ratner, Nancy

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Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone von Isfort, Ilka, Elges, Sandra, Cyra, Magdalene, Berthold, Ruth, Renner, Marcus, Mechtersheimer, Gunhild, Åman, Pierre, Larsson, Olle, Ratner, Nancy, Hafner, Susanne, Simmet, Thomas, Schliemann, Christoph, Rossig, Claudia, Dirksen, Uta, Grünewald, Inga, Wardelmann, Eva, Huss, Sebastian, Hartmann, Wolfgang, Trautmann, Marcel

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Plexiform and Dermal Neurofibromas and Pigmentation Are Caused by Nf1 Loss in Desert Hedgehog-Expressing Cells von Wu, Jianqiang, Williams, Jon P., Rizvi, Tilat A., Kordich, Jennifer J., Witte, David, Meijer, Dies, Stemmer-Rachamimov, Anat O., Cancelas, Jose A., Ratner, Nancy

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P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis von Patritti Cram, Jennifer, Wu, Jianqiang, Coover, Robert A, Rizvi, Tilat A, Chaney, Katherine E, Ravindran, Ramya, Cancelas, Jose A, Spinner, Robert J, Ratner, Nancy

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Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria von Plotkin, Scott R., Blakeley, Jaishri O., Evans, D. Gareth, Hanemann, C. Oliver, Hulsebos, Theo J.M., Hunter-Schaedle, Kim, Kalpana, Ganjam V., Korf, Bruce, Messiaen, Ludwine, Papi, Laura, Ratner, Nancy, Sherman, Larry S., Smith, Miriam J., Stemmer-Rachamimov, Anat O., Vitte, Jeremie, Giovannini, Marco

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Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment von Kershner, Leah J, Choi, Kwangmin, Wu, Jianqiang, Zhang, Xiyuan, Perrino, Melissa, Salomonis, Nathan, Shern, Jack F, Ratner, Nancy

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Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: implications for immunotherapy von Haworth, Kellie B, Arnold, Michael A, Pierson, Christopher R, Choi, Kwangmin, Yeager, Nicholas D, Ratner, Nancy, Roberts, Ryan D, Finlay, Jonathan L, Cripe, Timothy P

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The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminati... von Rice, Frank L, Houk, George, Wymer, James P, Gosline, Sara J C, Guinney, Justin, Wu, Jianqiang, Ratner, Nancy, Jankowski, Michael P, La Rosa, Salvo, Dockum, Marilyn, Storey, James R, Carroll, Steven L, Albrecht, Phillip J, Riccardi, Vincent M

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Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors von Paudel, Siddhi N, Hutzen, Brian J, Miller, Katherine E, Garfinkle, Elizabeth A R, Chen, Chun-Yu, Wang, Pin-Yi, Glaspell, Andrea M, Currier, Mark A, Ringwalt, Emily M, Boon, Louis, Mardis, Elaine R, Cairo, Mitchell S, Ratner, Nancy, Dodd, Rebecca D, Cassady, Kevin A, Cripe, Timothy P

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Abstract IA15: Using gene expression analyses to identify MPNST therapeutics von Ratner, Nancy

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