The Chemical Biology of Ferroptosis in the Central Nervous System von Ratan, Rajiv R.

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Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis von Zille, Marietta, Karuppagounder, Saravanan S, Chen, Yingxin, Gough, Peter J, Bertin, John, Finger, Joshua, Milner, Teresa A, Jonas, Elizabeth A, Ratan, Rajiv R

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Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate von Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V

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The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease von Aimé, Pascaline, Karuppagounder, Saravanan S., Rao, Apeksha, Chen, Yingxin, Burke, Robert E., Ratan, Rajiv R., Greene, Lloyd A.

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Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke von Speer, Rachel E., Karuppagounder, Saravanan S., Basso, Manuela, Sleiman, Sama F., Kumar, Amit, Brand, David, Smirnova, Natalya, Gazaryan, Irina, Khim, Soah J., Ratan, Rajiv R.

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Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats von Ferguson, Adam R, Irvine, Karen-Amanda, Gensel, John C, Nielson, Jessica L, Lin, Amity, Ly, Johnathan, Segal, Mark R, Ratan, Rajiv R, Bresnahan, Jacqueline C, Beattie, Michael S

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HDAC6 is a target for protection and regeneration following injury in the nervous system von Rivieccio, Mark A, Brochier, Camille, Willis, Dianna E, Walker, Breset A, D'Annibale, Melissa A, McLaughlin, Kathryn, Siddiq, Ambreena, Kozikowski, Alan P, Jaffrey, Samie R, Twiss, Jeffery L, Ratan, Rajiv R, Langley, Brett

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Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease von Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A, Hushpulian, Dmitry M, Liby, Karen T, Williams, Charlotte R, Yamamoto, Masayuki, Kensler, Thomas W, Ratan, Rajiv R, Sporn, Michael B, Beal, M Flint, Gazaryan, Irina G, Thomas, Bobby

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Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke von Yigitkanli, Kazim, Pekcec, Anton, Karatas, Hulya, Pallast, Stefanie, Mandeville, Emiri, Joshi, Netra, Smirnova, Natalya, Gazaryan, Irina, Ratan, Rajiv R., Witztum, Joseph L., Montaner, Joan, Holman, Theodore R., Lo, Eng H., van Leyen, Klaus

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ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo von Lange, Philipp S, Chavez, Juan C, Pinto, John T, Coppola, Giovanni, Sun, Chiao-Wang, Townes, Tim M, Geschwind, Daniel H, Ratan, Rajiv R

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Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice von Lee, Junghee, Kosaras, Bela, Del Signore, Steve J., Cormier, Kerry, McKee, Ann, Ratan, Rajiv R., Kowall, Neil W., Ryu, Hoon

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Targeting oxidative distress to treat chemobrain: Go with the choroid plexus-cerebrospinal fluid flow von Ratan, Rajiv R.

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Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors von Zille, Marietta, Kumar, Amit, Kundu, Nandini, Bourassa, Megan W, Wong, Victor S C, Willis, Dianna, Karuppagounder, Saravanan S, Ratan, Rajiv R

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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice von Ferrante, Robert J, Kubilus, James K, Lee, Junghee, Ryu, Hoon, Beesen, Ayshe, Zucker, Birgit, Smith, Karen, Kowall, Neil W, Ratan, Rajiv R, Luthi-Carter, Ruth, Hersch, Steven M

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Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease von Gardian, Gabriella, Browne, Susan E., Choi, Dong-Kug, Klivenyi, Peter, Gregorio, Jason, Kubilus, James K., Ryu, Hoon, Langley, Brett, Ratan, Rajiv R., Ferrante, Robert J., Beal, M. Flint

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Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway von Haskew-Layton, Renée E., Payappilly, Jimmy B., Smirnova, Natalya A., Ma, Thong C., Chan, Kelvin K., Murphy, Timothy H., Guo, Hengchang, Langley, Brett, Sultana, Rukhsana, Butterfield, D. Allan, Santagata, Sandro, Alldred, Melissa J., Gazaryan, Irina G., Bell, George W., Ginsberg, Stephen D., Ratan, Rajiv R.

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Translational Control of Inducible Nitric Oxide Synthase Expression by Arginine Can Explain the Arginine Paradox von Lee, Junghee, Ryu, Hoon, Ferrante, Robert J., Morris, Sidney M., Ratan, Rajiv R.

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Paired Associative Stimulation as a Tool to Assess Plasticity Enhancers in Chronic Stroke von Silverstein, Joshua, Cortes, Mar, Tsagaris, Katherine Zoe, Climent, Alejandra, Gerber, Linda M, Oromendia, Clara, Fonzetti, Pasquale, Ratan, Rajiv R, Kitago, Tomoko, Iacoboni, Marco, Wu, Allan, Dobkin, Bruce, Edwards, Dylan J

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Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation von Basso, Manuela, Berlin, Jill, Xia, Li, Sleiman, Sama F, Ko, Brendan, Haskew-Layton, Renee, Kim, Eunhee, Antonyak, Marc A, Cerione, Richard A, Iismaa, Siiri E, Willis, Dianna, Cho, Sunghee, Ratan, Rajiv R

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N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mi... von Karuppagounder, Saravanan S., Alin, Lauren, Chen, Yingxin, Brand, David, Bourassa, Megan W., Dietrich, Kristen, Wilkinson, Cassandra M., Nadeau, Colby A., Kumar, Amit, Perry, Steve, Pinto, John T., Darley‐Usmar, Victor, Sanchez, Stephanie, Milne, Ginger L., Pratico, Domenico, Holman, Theodore R., Carmichael, S. Thomas, Coppola, Giovanni, Colbourne, Frederick, Ratan, Rajiv R.

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