Efficient synthesis of 5-alkyl amino and thioether substituted pyrazoles von Sakya, Subas M, Rast, Bryson

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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and o... von Sakya, Subas M., Lundy DeMello, Kristin M., Minich, Martha L., Rast, Bryson, Shavnya, Andrei, Rafka, Robert J., Koss, David A., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Lund, Lisa A., Denis, Suzanne St, Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine von Li, Jin, DeMello, Kristin M.Lundy, Cheng, Henry, Sakya, Subas M., Bronk, Brian S., Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Kilroy, Carolyn, Mann, Donald W., Nimz, Eric L., Lynch, Michael P., Haven, Michelle L., Kolosko, Nicole L., Minich, Martha L., Li, Chao, Dutra, Jason K., Rast, Bryson, Crosson, Rhonda M., Morton, Barry J., Kirk, Glen W., Callaghan, Kathleen M., Koss, David A., Shavnya, Andrei, Lund, Lisa A., Seibel, Scott B., Petras, Carol F., Silvia, Annette

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Non-oxime inhibitors of B-Raf(V600E) kinase von Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J, Ely, Robert J, Schlachter, Stephen, Laird, Ellen R, Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J, Vigers, Guy, Morales, Tony, Voegtli, Walter C, Lyssikatos, Joseph

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The Discovery of furo[2,3- c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors von Buckmelter, Alex J., Ren, Li, Laird, Ellen R., Rast, Bryson, Miknis, Greg, Wenglowsky, Steve, Schlachter, Stephen, Welch, Mike, Tarlton, Eugene, Grina, Jonas, Lyssikatos, Joseph, Brandhuber, Barbara J., Morales, Tony, Randolph, Nikole, Vigers, Guy, Martinson, Matthew, Callejo, Michele

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Facile microwave assisted decarbonylation of 4-formyl group in 5-alkyl amino substituted pyrazoles von Sakya, Subas M., Abrams, Barbara, Snow, Sheri L., Rast, Bryson

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Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles von Shavnya, Andrei, Sakya, Subas M., Minich, Martha L., Rast, Bryson, Lundy DeMello, Kristin, Jaynes, Burton H.

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Non-oxime inhibitors of B-Raf super(V600E) kinase von Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J, Ely, Robert J, Schlachter, Stephen, Laird, Ellen R, Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J, Vigers, Guy, Morales, Tony, Voegtli, Walter C, Lyssikatos, Joseph

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Abstract 551: A potent and selective cFMS inhibitor regulates the tumor macrophage microenvironment leading to tumor growth inhibition von Wright, Albion D., Willis, Brandon S., Gomez, Anna, Boys, Mark L., DeLisle, Robert K., Burgess, Laurence E., Munson, Mark C., Kennedy, April L., Topalov, George T., Zhao, Qian, Rodriguez, Martha E., Rast, Bryson, Rizzi, James P., DeWolf, Walter E., Lemieux, Christine, Anderson, Deborah, Neale, Jason R., Martinson, Matthew, Gross, Stefan D., Callejo, Michele, Risom, Tyler, Lee, Patrice A.

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Non-oxime inhibitors of B-Raf V600E kinase von Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J., Ely, Robert J., Schlachter, Stephen, Laird, Ellen R., Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J., Vigers, Guy, Morales, Tony, Voegtli, Walter C., Lyssikatos, Joseph

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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile von Sakya, Subas M., Hou, Xinjun, Minich, Martha L., Rast, Bryson, Shavnya, Andrei, DeMello, Kristin M.L., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Haven, Michelle L.

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Non-oxime inhibitors of B-Rafⱽ⁶⁰⁰ᴱ kinase von Ren, Li, Wenglowsky, Steve, Miknis, Greg, Rast, Bryson, Buckmelter, Alex J, Ely, Robert J, Schlachter, Stephen, Laird, Ellen R, Randolph, Nikole, Callejo, Michele, Martinson, Matthew, Galbraith, Sarah, Brandhuber, Barbara J, Vigers, Guy, Morales, Tony, Voegtli, Walter C, Lyssikatos, Joseph

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5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers von Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

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Comparative structure–activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition von Sakya, Subas M., Shavnya, Andrei, Cheng, Hengmiao, Li, Chao, Rast, Bryson, Li, Jin, Koss, David A., Jaynes, Burton H., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Haven, Michelle L., Lynch, Michael P.

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Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors von Munson, Mark C, Hicken, Erik James, Zhao, Qian, Marmsäter, Fredrik P, Kennedy, April L, Rast, Bryson, Rizzi, James P, Newhouse, Brad, Rodriguez, Martha E, Boys, Mark Laurence, Topalov, George T, DeLisle, Robert Kirk, Mareska, David A

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SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS von FREDRIK P. MARMSATER, DAVID A. MARESKA, MARTHA E. RODRIGUEZ, APRIL L. KENNEDY, BRYSON RAST, ERIC JAMES HICKEN, BRAD NEWHOUSE, QIAN ZHAO, ROBERT KIRK DELISLE, JAMES P. RIZZI, MARK C. MUNSON, MARK LAURENCE BOYS, GEORGE T. TOPALOV

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SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-a]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS von Munson, Mark C, Hicken, Erik James, Zhao, Qian, Kennedy, April L, Rast, Bryson, Rizzi, James P, Newhouse, Brad, Rodriguez, Martha E, Marmsater, Fredrik P, Boys, Mark Laurence, Topalov, George T, Delisle, Robert Kirk, Mareska, David A

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SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS von MUNSON, MARK C, RAST, BRYSON, DELISLE, ROBERT KIRK, TOPALOV, GEORGE T, MARESKA, DAVID A, HICKEN, ERIK JAMES, ZHAO, QIAN, RIZZI, JAMES P, BOYS, MARK LAURENCE, KENNEDY, APRIL L, NEWHOUSE, BRAD, MARMSATER, FREDRIK P, RODRIGUEZ, MARTHA E

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SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDE COMPOUNDS AS CFMS INHIBITORS von MUNSON, MARK C, MEDINA, MATTHEW, RAST, BRYSON, DELISLE, ROBERT KIRK, TOPALOV, GEORGE T, ZHAO, QIAN, BRADLEY, MICHAEL, RIZZI, JAMES P, BOYS, MARK LAURENCE, KENNEDY, APRIL L, MARMSATER, FREDRIK P, HENNINGS, D. DAVID, RODRIGUEZ, MARTHA E

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Efficient Synthesis of 5-Alkyl Amino and Thioether Substituted Pyrazoles von Sakya, Subas M., Rast, Bryson

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