Nitisinone Treatment Affects Biomarkers of Bone and Cartilage Remodelling in Alkaptonuria Patients von Genovese, Federica, Frederiksen, Peder, Bay-Jensen, Anne-Christine, Karsdal, Morten A, Milan, Anna M, Olsson, Birgitta, Rudebeck, Mattias, Gallagher, James A, Ranganath, Lakshminarayan R

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Clinical development innovation in rare diseases: lessons learned and best practices from the DevelopAKUre consortium von Rudebeck, Mattias, Scott, Ciarán, Rhodes, Nicholas P, van Kan, Christa, Olsson, Birgitta, Al-Sbou, Mohammed, Hall, Anthony K, Sireau, Nicolas, Ranganath, Lakshminarayan R

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Correction: Zatkova et al. Analysis of the Phenotype Differences in Siblings with Alkaptonuria. Metabolites 2022, 12 , 990 von Zatkova, Andrea, Olsson, Birgitta, Ranganath, Lakshminarayan R, Imrich, Richard

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Analysis of the Phenotype Differences in Siblings with Alkaptonuria von Zatkova, Andrea, Olsson, Birgitta, Ranganath, Lakshminarayan R, Imrich, Richard

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Receptors and effects of gut hormones in three osteoblastic cell lines von Pacheco-Pantoja, Elda L, Ranganath, Lakshminarayan R, Gallagher, James A, Wilson, Peter J M, Fraser, William D

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First decade anniversary of the United Kingdom National Alkaptonuria Centre von Khedr, Milad, Sireau, Nick, Bou‐Gharios, George, Gallagher, Jim A., Ranganath, Lakshminarayan R.

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Long‐term low dose nitisinone therapy in adults with alkaptonuria shows no cognitive decline or increased severity of depression von Davison, Andrew S., Hughes, Gin, Harrold, Joanne A., Clarke, Pam, Griffin, Rebecca, Ranganath, Lakshminarayan R.

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Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism von Norman, Brendan P., Davison, Andrew S., Hughes, Juliette H., Sutherland, Hazel, Wilson, Peter JM, Berry, Neil G., Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Roberts, Norman B., Ranganath, Lakshminarayan R., Bou-Gharios, George, Gallagher, James A.

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Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial von Ooi, Nicola, Cooper, Ian R, Norman, Brendan, Gallagher, James A, Sireau, Nick, Bou-Gharios, George, Ranganath, Lakshminarayan R, Savage, Victoria J

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Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria von Davison, Andrew S, Norman, Brendan P, Sutherland, Hazel, Milan, Anna M, Gallagher, James A, Jarvis, Jonathan C, Ranganath, Lakshminarayan R

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Association of alkaptonuria and low dose nitisinone therapy with cataract formation in a large cohort of patients von Ahmad, Mohammad S. Z., Ahmed, Mahmoud, Khedr, Milad, Borgia, Alfredo, Madden, Andrea, Ranganath, Lakshminarayan R., Kaye, Stephen

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Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatmen... von Ranganath, Lakshminarayan R, Milan, Anna M, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A

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Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria von Ranganath, Lakshminarayan R, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A, Milan, Anna M

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Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling von Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Norman, Brendan P., Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A., Jackson, Richard

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Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria von Norman, Brendan P, Davison, Andrew S, Hickton, Bryony, Ross, Gordon A, Milan, Anna M, Hughes, Andrew T, Wilson, Peter J. M, Sutherland, Hazel, Hughes, Juliette H, Roberts, Norman B, Bou-Gharios, George, Gallagher, James A, Ranganath, Lakshminarayan R

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Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease—A review von Ranganath, Lakshminarayan R., Norman, Brendan P., Gallagher, James A.

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Improving the clinical accuracy and flexibility of the Alkaptonuria severity score index von Cant, Harriet E. O., Chatzidaki, Iro, Olsson, Birgitta, Rudebeck, Mattias, Arnoux, Jean‐Baptiste, Imrich, Richard, Eddowes, Lucy A., Ranganath, Lakshminarayan R.

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Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies von Braconi, Daniela, Geminiani, Michela, Psarelli, Eftychia Eirini, Giustarini, Daniela, Marzocchi, Barbara, Rossi, Ranieri, Bernardini, Giulia, Spiga, Ottavia, Gallagher, James A, Le Quan Sang, Kim-Hanh, Arnoux, Jean-Baptiste, Imrich, Richard, Al-Sbou, Mohammed S, Gornall, Matthew, Jackson, Richard, Ranganath, Lakshminarayan R, Santucci, Annalisa

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Recent advances in management of alkaptonuria (invited review; best practice article) von Ranganath, Lakshminarayan R, Jarvis, Jonathan C, Gallagher, James A

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Radiological evolution of spinal disease in alkaptonuria and the effect of nitisinone von Imrich, Richard, Sedláková, Jana, Úlehlová, Mária, Gornall, Matthew, Jackson, Richard, Olsson, Birgitta, Rudebeck, Mattias, Gallagher, James, Lukáčová, Oľga, Mlynáriková, Vanda, Stančík, Roman, Vrtíková, Eva, Záňová, Elizabeth, Zaťková, Andrea, Arnoux, Jean-Baptiste, Rovenský, Jozef, Luangrath, Emily, Bygott, Helen, Khedr, Milad, Ranganath, Lakshminarayan R

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