Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5A von DeGoey, David A., Randolph, John T., Liu, Dachun, Pratt, John, Hutchins, Charles, Donner, Pamela, Krueger, A. Chris, Matulenko, Mark, Patel, Sachin, Motter, Christopher E., Nelson, Lissa, Keddy, Ryan, Tufano, Michael, Caspi, Daniel D., Krishnan, Preethi, Mistry, Neeta, Koev, Gennadiy, Reisch, Thomas J., Mondal, Rubina, Pilot-Matias, Tami, Gao, Yi, Beno, David W. A., Maring, Clarence J., Molla, Akhter, Dumas, Emily, Campbell, Andrew, Williams, Laura, Collins, Christine, Wagner, Rolf, Kati, Warren M.

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In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir von Ng, Teresa I, Krishnan, Preethi, Pilot-Matias, Tami, Kati, Warren, Schnell, Gretja, Beyer, Jill, Reisch, Thomas, Lu, Liangjun, Dekhtyar, Tatyana, Irvin, Michelle, Tripathi, Rakesh, Maring, Clarence, Randolph, John T, Wagner, Rolf, Collins, Christine

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Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro von Lu, Liangjun, Pilot-Matias, Tami J, Stewart, Kent D, Randolph, John T, Pithawalla, Ron, He, Wenping, Huang, Peggy P, Klein, Larry L, Mo, Hongmei, Molla, Akhteruzzaman

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Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase von Liu, Yaya, Lim, Ben Hock, Jiang, Wen W., Flentge, Charles A., Hutchinson, Douglas K., Madigan, Darold L., Randolph, John T., Wagner, Rolf, Maring, Clarence J., Kati, Warren M., Molla, Akhteruzzaman

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Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model von Marvin, Christopher C., Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Bischoff, Agnieszka K., Fitzgibbons, Julia, Wang, Lu, Wang, Lu, Hernandez, Axel, Jia, Ying, Goess, Christian A., Bryant, Shaughn H., Mathieu, Suzanne L., Xu, Jianwen

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Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo von Randolph, John T., O’Connor, Matthew J., Han, Fei, Hutchins, Charles W., Siu, Y. Amy, Cho, Min, Zheng, Yunan, Hickson, Jonathan A., Markley, Jana L., Manaves, Vlasios, Algire, Mikkel, Baker, Kenton A., Chapman, Alex M., Gopalakrishnan, Sujatha M., Panchal, Sanjay C., Foster-Duke, Kelly, Stolarik, DeAnne F., Kempf-Grote, Anita, Dammeier, Darby, Fossey, Stacey, Sun, Qi, Sun, Chaohong, Shen, Yu, Dart, Michael J., Kati, Warren M., Lai, Albert, Firestone, Ari J., Kort, Michael E.

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Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate von Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa

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Highlights of the Structure–Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530) von Wagner, Rolf, Randolph, John T, Patel, Sachin V, Nelson, Lissa, Matulenko, Mark A, Keddy, Ryan, Pratt, John K, Liu, Dachun, Krueger, A. Chris, Donner, Pamela L, Hutchinson, Douglas K, Flentge, Charles, Betebenner, David, Rockway, Todd, Maring, Clarence J, Ng, Teresa I, Krishnan, Preethi, Pilot-Matias, Tami, Collins, Christine, Panchal, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Mondal, Rubina, Stolarik, DeAnne F, Gao, Yi, Gao, Wenqing, Beno, David A, Kati, Warren M

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Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530) von Randolph, John T, Voight, Eric A, Greszler, Stephen N, Uno, Brice E, Newton, James N, Gleason, Kenneth M, Stolarik, DeAnne, Van Handel, Cecilia, Bow, Daniel A. J, DeGoey, David A

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Desymmetrization of pibrentasvir for efficient prodrug synthesis von Voight, Eric A, Greszler, Stephen N, Hartung, John, Ji, Jianguo, Klix, Russell C, Randolph, John T, Shelat, Bhadra H, Waters, Jan E, DeGoey, David A

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Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate” von Hobson, Adrian D., McPherson, Michael J., Hayes, Martin E., Goess, Christian, Li, Xiang, Zhou, Jian, Wang, Zhongyuan, Yu, Yajie, Yang, Jindong, Sun, Liang, Zhang, Qiang, Qu, Pei, Yang, Shi, Hernandez, Axel, Bryant, Shaughn H., Mathieu, Suzanne L., Bischoff, Agnieszka K., Fitzgibbons, Julia, Santora, Ling C., Wang, Lu, Wang, Lu, Fettis, Margaret M., Li, Xiaofeng, Marvin, Christopher C., Wang, Zhi, Patel, Meena V., Schmidt, Diana L., Li, Tongmei, Randolph, John T., Henry, Rodger F., Graff, Candace, Tian, Yu, Aguirre, Ana L., Shrestha, Anurupa

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A Strategy for the Solid-Phase Synthesis of Oligosaccharides von Danishefsky, Samuel J., McClure, Kim F., Randolph, John T., Ruggeri, Roger B.

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Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors von Randolph, John T., Li, Tongmei, Chris Krueger, A., Heyman, Howard R., Chen, Hui-Ju, Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle, Krishnan, Preethi, Wagner, Rolf, DeGoey, David A.

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Major Simplifications in Oligosaccharide Syntheses Arising from a Solid-Phase Based Method: An Application to the Synthesis of the Lewis b Antigen von Randolph, John T, McClure, Kim F, Danishefsky, Samuel J

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Synthesis and evaluation of 2′-dihalo ribonucleotide prodrugs with activity against hepatitis C virus von Chris Krueger, A., Chen, Hui-Ju, Randolph, John T., Brown, Brian S., Halvorsen, Geoff T., Heyman, Howard R., Li, Tongmei, Marvin, Christopher C., Shanley, Jason P., Voight, Eric A., Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle L., Krishnan, Preethi, Henry, Rodger F., Wagner, Rolf, DeGoey, David A.

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Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailabili... von Randolph, John T, Krueger, A. Chris, Donner, Pamela L, Pratt, John K, Liu, Dachun, Motter, Christopher E, Rockway, Todd W, Tufano, Michael D, Wagner, Rolf, Lim, Hock B, Beyer, Jill M, Mondal, Rubina, Panchal, Neeta S, Colletti, Lynn, Liu, Yaya, Koev, Gennadiy, Kati, Warren M, Hernandez, Lisa E, Beno, David W. A, Longenecker, Kenton L, Stewart, Kent D, Dumas, Emily O, Molla, Akhteruzzaman, Maring, Clarence J

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Practical Preclinical Model for Assessing the Potential for Unconjugated Hyperbilirubinemia Produced by Human Immunodeficiency Virus Protease Inhibitors von KEMPF, Dale J, WARING, Jeffrey F, MARSH, Kennan, MORFITT, David C, WERNER, Paige, EBERT, Brian, MITTEN, Michael, NGUYEN, Bach, RANDOLPH, John T, DEGOEY, David A, KLEIN, Larry L

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Discovery of fluorobenzimidazole HCV NS5A inhibitors von Randolph, John T., Flentge, Charles A., Donner, Pamela, Rockway, Todd W., Patel, Sachin V., Nelson, Lissa, Hutchinson, Douglas K., Mondal, Rubina, Mistry, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Krishnan, Preethi, Pilot-Matias, Tami, Stolarik, Deanne F., Beno, David W.A., Wagner, Rolf, Maring, Clarence, Kati, Warren M.

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Total Synthesis of a Human Breast Tumor Associated Antigen von Bilodeau, Mark T, Park, Tae Kyo, Hu, Shuanghua, Randolph, John T, Danishefsky, Samuel J, Livingston, Philip O, Zhang, Shengli

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High potency improvements to weak aryl uracil HCV polymerase inhibitor leads von Donner, Pamela, Randolph, John T., Huang, Peggy, Wagner, Rolf, Maring, Clarence, Lim, Ben Hock, Colletti, Lynn, Liu, Yaya, Mondal, Rubina, Beyer, Jill, Koev, Gennadiy, Marsh, Kennan, Beno, David, Longenecker, Kenton, Pilot-Matias, Tami, Kati, Warren, Molla, Akhter, Kempf, Dale

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