Discovery of Potent and Selective RSK Inhibitors as Biological Probes von Jain, Rama, Mathur, Michelle, Lan, Jiong, Costales, Abran, Atallah, Gordana, Ramurthy, Savithri, Subramanian, Sharadha, Setti, Lina, Feucht, Paul, Warne, Bob, Doyle, Laura, Basham, Stephen, Jefferson, Anne B., Lindvall, Mika, Appleton, Brent A., Shafer, Cynthia M.

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Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma von Williams, Teresa E, Subramanian, Sharadha, Verhagen, Joelle, McBride, Christopher M, Costales, Abran, Sung, Leonard, Antonios-McCrea, William, McKenna, Maureen, Louie, Alicia K, Ramurthy, Savithri, Levine, Barry, Shafer, Cynthia M, Machajewski, Timothy, Renhowe, Paul A, Appleton, Brent A, Amiri, Payman, Chou, James, Stuart, Darrin, Aardalen, Kimberly, Poon, Daniel

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Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhi... von Ramurthy, Savithri, Taft, Benjamin R., Aversa, Robert J., Barsanti, Paul A., Burger, Matthew T., Lou, Yan, Nishiguchi, Gisele A., Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A., Mamo, Mulugeta, Tandeske, Laura, Tellew, John E., Huang, Shenlin, Yue, Qn, Cliaudliary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Griner, Lesley A. Mathews, La Bonte, Laura R., Cooke, Vesselina G., Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R., Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R., Lees, Emma, Shao, Wenlin, Dillon, Michael P., Stuart, Darrin D.

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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inh... von Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

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GCN2 조정 화합물 및 그의 용도 von SHERBORNE BRADLEY, THOMSON CHRISTOPHER G, RAHEMTULLA BENJAMIN, TALBOT ERIC P. A, MULVIHILL MARK J, RAMURTHY SAVITHRI

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Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors von Ramurthy, Savithri, Pfister, Keith B., Boyce, Rustum S., Brown, Sean P., Costales, Abran Q., Desai, Manoj C., Fang, Eric, Levine, Barry H., Ng, Simon C., Nuss, John M., Ring, David B., Shafer, Cynthia M., Shu, Wei, Subramanian, Sharadha, Wagman, Allan S., Wang, Haixia, Bussiere, Dirksen E.

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Design and synthesis of potent RSK inhibitors von Jain, Rama, Mathur, Michelle, Lan, Jiong, Costales, Abran, Atallah, Gordana, Ramurthy, Savithri, Subramanian, Sharadha, Setti, Lina, Feucht, Paul, Warne, Bob, Doyle, Laura, Basham, Stephen, Jefferson, Anne B., Appleton, Brent A., Lindvall, Mika, Shafer, Cynthia M.

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Inhibition of prenylated KRAS in a lipid environment von Jansen, Johanna M, Wartchow, Charles, Jahnke, Wolfgang, Fong, Susan, Tsang, Tiffany, Pfister, Keith, Zavorotinskaya, Tatiana, Bussiere, Dirksen, Cheng, Jan Marie, Crawford, Kenneth, Dai, Yumin, Dove, Jeffrey, Fang, Eric, Feng, Yun, Florent, Jean-Michel, Fuller, John, Gossert, Alvar D, Hekmat-Nejad, Mohammad, Henry, Chrystèle, Klopp, Julia, Lenahan, William P, Lingel, Andreas, Ma, Sylvia, Meyer, Arndt, Mishina, Yuji, Narberes, Jamie, Pardee, Gwynn, Ramurthy, Savithri, Rieffel, Sebastien, Stuart, Darrin, Subramanian, Sharadha, Tandeske, Laura, Widger, Stephania, Widmer, Armin, Winterhalter, Aurelie, Zaror, Isabel, Hardy, Stephen

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Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation von Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Ramurthy, Savithri, Cooke, Vesselina, Griner, Lesley, Nishiguchi, Gisele, Rico, Alice, Taft, Ben, Burger, Matthew, Tanner, Huw, Polyakov, Valery, Appleton, Brent, Tellew, John, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Stuart, Darrin

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Abstract 330: Development of a highly selective BCRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation von Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Ramurthy, Savithri, Cooke, Vesselina, Griner, Lesley, Nishiguchi, Gisele, Rico, Alice, Taft, Ben, Burger, Matthew, Tanner, Huw, Polyakov, Valery, Appleton, Brent, Tellew, John, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Stuart, Darrin

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Peptidomimetics of the immunoglobulin supergene family — a review von Nakanishi, Hiroshi, Ramurthy, Savithri, Raktabutr, Apichaya, Shen, Richard, Kahn, Michael

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Design and synthesis of 6,6-fused heterocyclic amides as raf kinase inhibitors von Ramurthy, Savithri, Costales, Abran, Jansen, Johanna M., Levine, Barry, Renhowe, Paul A., Shafer, Cynthia M., Subramanian, Sharadha

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Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors von Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J, Dillon, Michael P, Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathur, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin

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4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors von Ni, Zhi-Jie, Barsanti, Paul, Brammeier, Nathan, Diebes, Anthony, Poon, Daniel J., Ng, Simon, Pecchi, Sabina, Pfister, Keith, Renhowe, Paul A., Ramurthy, Savithri, Wagman, Allan S., Bussiere, Dirksen E., Le, Vincent, Zhou, Yasheen, Jansen, Johanna M., Ma, Sylvia, Gesner, Thomas G.

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Abstract B38: Inhibiting mutated KRAS, a broken switch of effector pathways von Jansen, Johanna, Jahnke, Wolfgang, Fong, Susan, Tandeske, Laura, Wartchow, Charles, Pfister, Keith, Zavorotinskaya, Tatiana, Blechschmidt, Anke, Bussiere, Dirksen, Dai, Yumin, Dove, Jeff, Fang, Eric, Farley, David, Florent, Jean-Michel, Fuller, John, Gokhin, Simona, Gossert, Alvar, Hekmat-Nejad, Mohammad, Henry, Chrystèle, Klopp, Julia, Lenahan, Bill, Lingel, Andreas, Meyer, Arndt, Narberes, Jamie, Pardee, Gwynn, Paris, C Gregory, Ramurthy, Savithri, Renhowe, Paul, Rieffel, Sebastien, Shoemaker, Kevin, Subramanian, Sharadha, Tsang, Tiffany, Widger, Stephania, Widmer, Armin, Zaror, Isabel, Hardy, Stephen

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Correction to Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors von Subramanian, Sharadha, Costales, Abran, Williams, Teresa E, Levine, Barry, McBride, Christopher M, Poon, Daniel, Amiri, Payman, Renhowe, Paul A, Shafer, Cynthia M, Stuart, Darrin, Verhagen, Joelle, Ramurthy, Savithri

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DIHYDROPYRROLIDINO-PYRIMIDINES AS KINASE INHIBITORS von RAUNIYAR VIVEK, DILLON MICHAEL PATRICK, TANNER HUW, LINDVALL MIKA, POON DANIEL, RAMURTHY SAVITHRI, SHAFER CYNTHIA, SUBRAMANIAN SHARADHA

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BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS von BURGER MATTHEW, HU CHENG, NISHIGUCHI GISELE, DIPESA ALAN, WAN LIFENG, PAN YUE, SMITH AARON, RICO ALICE, YUSUFF NAEEM, LOU YAN, BARSANTI PAUL A, DILLON MICHAEL PATRICK, AVERSA ROBERT, TANNER HUW, POLYAKOV VALERY, TAFT BENJAMIN, RAMURTHY SAVITHRI, SETTI LINA, SUBRAMANIAN SHARADHA

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GCN2 MODULATING COMPOUNDS AND USES THEREOF von THOMSON, Christopher G, TALBOT, Eric P. A, RAMURTHY, Savithri, RAHEMTULLA, Benjamin, MULVIHILL, Mark J, SHERBORNE, Bradley

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GCN2 MODULATING COMPOUNDS AND USES THEREOF von THOMSON, Christopher G, TALBOT, Eric P. A, RAMURTHY, Savithri, RAHEMTULLA, Benjamin, MULVIHILL, Mark J, SHERBORNE, Bradley

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