Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes von Bantscheff, Marcus, Drewes, Gerard, Hopf, Carsten, Savitski, Mikhail M, Dittmann, Antje, Grandi, Paola, Michon, Anne-Marie, Schlegl, Judith, Abraham, Yann, Becher, Isabelle, Bergamini, Giovanna, Boesche, Markus, Delling, Manja, Dümpelfeld, Birgit, Eberhard, Dirk, Huthmacher, Carola, Mathieson, Toby, Poeckel, Daniel, Reader, Valérie, Strunk, Katja, Sweetman, Gavain, Kruse, Ulrich, Neubauer, Gitte, Ramsden, Nigel G

Volltext

Interrogating the Druggability of the 2‑Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics von Joberty, Gérard, Boesche, Markus, Brown, Jack A, Eberhard, Dirk, Garton, Neil S, Humphreys, Philip G, Mathieson, Toby, Muelbaier, Marcel, Ramsden, Nigel G, Reader, Valérie, Rueger, Anne, Sheppard, Robert J, Westaway, Susan M, Bantscheff, Marcus, Lee, Kevin, Wilson, David M, Prinjha, Rab K, Drewes, Gerard

Volltext

Interfacing Sail Modules for Use with “Space Tugs” von Dalla Vedova, Florio, Morin, Pierre, Roux, Thibault, Brombin, Roberta, Piccinini, Alberto, Ramsden, Nigel

Volltext

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors von Reader, Valérie, Neubauer, Gitte, Rick, Jens, Hobson, Scott, Kuster, Bernhard, Bantscheff, Marcus, Perrin, Jessica, Boesche, Markus, Bastuck, Sonja, Kruse, Ulrich, Abraham, Yann, Drewes, Gerard, Rau, Christina, Mathieson, Toby, Raida, Manfred, Bouwmeester, Tewis, Ramsden, Nigel, Eberhard, Dirk, Hopf, Carsten, Sweetman, Gavain, Bauer, Andreas

Volltext

Strategic Pooling of Compounds for High-Throughput Screening von Hann, Mike, Hudson, Brian, Lewell, Xiao, Lifely, Rob, Miller, Luke, Ramsden, Nigel

Volltext

EXTH-07. AN ANTISENSE OLIGONUCLEOTIDE AGAINST TUMOR MICROTUBES IN GLIOBLASTOMA AS A NEW THERAPEUTIC OPTION TO IMPROVE TUMOR SPECIFIC THERAPY von Weil, Sophie, Azorín, Daniel Domínguez, Jung, Erik, Higgins, Josie, Mohammed, Hafeez, Reckless, Jill, Ramsden, Nigel, Keller, Peter, Grainger, David, Wick, Wolfgang, Winkler, Frank

Volltext

Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons von Ramsden, Nigel, Perrin, Jessica, Ren, Zhao, Lee, Byoung Dae, Zinn, Nico, Dawson, Valina L, Tam, Danny, Bova, Michael, Lang, Manja, Drewes, Gerard, Bantscheff, Marcus, Bard, Frederique, Dawson, Ted M, Hopf, Carsten

Volltext

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'Mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

Volltext

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'Mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

Volltext

SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors von Bell, Kathryn, Sunose, Mihiro, Ellard, Katie, Cansfield, Andrew, Taylor, Jess, Miller, Warren, Ramsden, Nigel, Bergamini, Giovanna, Neubauer, Gitte

Volltext

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for th... von Sunose, Mihiro, Bell, Kathryn, Ellard, Katie, Bergamini, Giovanna, Neubauer, Gitte, Werner, Thilo, Ramsden, Nigel

Volltext

Abstract 1084: AI-aided drug development for disconnecting glioma tumor microtube networks von Azorín, Daniel D., Weil, Sophie, Hoffmann, Dirk C., Hausmann, David, Jung, Erik, Osswald, Matthias, Reckless, Jill, Ramsden, Nigel, Thompson, Simon, Grainger, David, Wick, Wolfgang, Winkler, Frank

Volltext

Discovery of novel PI3Kγ/δ inhibitors as potential agents for inflammation von Ellard, Katie, Sunose, Mihiro, Bell, Kathryn, Ramsden, Nigel, Bergamini, Giovanna, Neubauer, Gitte

Volltext

Thrombin inhibitors based on [5,5] trans-fused indane lactams von Pass, Martin, Abu-Rabie, Said, Baxter, Andrew, Conroy, Richard, Coote, Steven J, Craven, Andrew P, Finch, Harry, Hindley, Seán, Kelly, Henry A, Lowdon, Andrew W, McDonald, Edward, Mitchell, William L, Pegg, Neil A, Procopiou, Pan A, Ramsden, Nigel G, Thomas, Rhian, Walker, Dawn A, Watson, Nigel S, Jhoti, Harren, Mooney, Christopher J, Tang, Chi-Man, Thomas, Pamela J, Parry, Simon, Patel, Champa

Volltext

Inhibition of HIV replication by amino-sugar derivatives von Fleet, George W.J., Karpas, Abraham, Dwek, Raymond A., Fellows, Linda E., Tyms, A.S., Petursson, Sigthor, Namgoong, Sung K., Ramsden, Nigel G., Smith, Paul W., Son, Jong Chan, Wilson, Francis, Witty, David R., Jacob, Gary S., Rademacher, Thomas W.

Volltext

SAR studies around a series of triazolopyridines as potent and selective PI3K[gamma] inhibitors von Bell, Kathryn, Sunose, Mihiro, Ellard, Katie, Cansfield, Andrew, Taylor, Jess, Miller, Warren, Ramsden, Nigel, Bergamini, Giovanna, Neubauer, Gitte

Volltext

Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists von Cramp, Sue, Dyke, Hazel J., Higgs, Christopher, Clark, David E., Gill, Matthew, Savy, Pascal, Jennings, Neil, Price, Steve, Lockey, Peter M., Norman, Dennis, Porres, Soraya, Wilson, Francis, Jones, Alison, Ramsden, Nigel, Mangano, Raffaella, Leggate, Dan, Andersson, Marie, Hale, Richard

Volltext

A selective inhibitor reveals PI3K[gamma] dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

Volltext

Erratum: Corrigendum: A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'Mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

Volltext

A selective inhibitor reveals PI3K[gamma] dependence of TH17 cell differentiation von Bergamini, Giovanna, Bell, Kathryn, Shimamura, Satoko, Werner, Thilo, Cansfield, Andrew, Müller, Katrin, Perrin, Jessica, Rau, Christina, Ellard, Katie, Hopf, Carsten, Doce, Carola, Leggate, Daniel, Mangano, Raffaella, Mathieson, Toby, O'mahony, Alison, Plavec, Ivan, Rharbaoui, Faiza, Reinhard, Friedrich, Savitski, Mikhail M, Ramsden, Nigel, Hirsch, Emilio, Drewes, Gerard, Rausch, Oliver, Bantscheff, Marcus, Neubauer, Gitte

Volltext